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1.发明授权Immunoconjugates of anti-IL-20 antibodies and hybridoma cell lines expressing anti-IL-20 antibodies 有权抗IL-20抗体的免疫偶联物和表达抗IL-20抗体的杂交瘤细胞系公开(公告)号：US07393684B2
公开(公告)日：2008-07-01
申请号：US10994116
申请日：2004-11-19
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Zhi Chen , Steven D. Hughes , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret D. Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Zhi Chen , Steven D. Hughes , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret D. Moore
IPC分类号： C12N5/20
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断IL-20多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。 本发明包括抗IL-20抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。
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2.发明授权Anti-IL-20 antibodies and binding partners and methods of using in inflammation 有权抗IL-20抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US08907068B2
公开(公告)日：2014-12-09
申请号：US12124946
申请日：2008-05-21
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Zhi Chen , Steven D. Hughes , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavar V. Sivakumar , Margaret D. Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Zhi Chen , Steven D. Hughes , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavar V. Sivakumar , Margaret D. Moore
IPC分类号： C07K16/24 , A61K38/17 , A61K47/48 , C07K16/28 , C07K14/715 , C07K14/54 , A61K38/20 , A61K39/00
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断IL-20多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。 本发明包括抗IL-20抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。
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公开(公告)号：US08524227B2
公开(公告)日：2013-09-03
申请号：US12732116
申请日：2010-03-25
IPC分类号： A61K39/395 , C07K16/22 , C07K16/24 , C07K14/54 , C12P21/08
CPC分类号： C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/34
摘要： The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
摘要翻译： 本发明涉及阻断IL-TIF多肽分子的活性。 IL-TIF是涉及炎症过程和人类疾病的细胞因子。 本发明包括抗IL-TIF抗体和结合配偶体，以及在IL-TIF相关的人类炎性疾病中使用这样的抗体和结合伴侣拮抗IL-TIF的方法，以及其它用途。
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4.发明申请ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权抗IL-20抗体和结合合作伙伴及其在炎症中的使用方法公开(公告)号：US20080247945A1
公开(公告)日：2008-10-09
申请号：US12124946
申请日：2008-05-21
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Zhi Chen , Steven D. Hughes , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavar V. Sivakumar , Margaret D. Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Zhi Chen , Steven D. Hughes , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavar V. Sivakumar , Margaret D. Moore
IPC分类号： A61K51/00 , C07K16/18 , A61P43/00 , A61K39/395
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断IL-20多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。 本发明包括抗IL-20抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。
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公开(公告)号：US08124088B2
公开(公告)日：2012-02-28
申请号：US12423699
申请日：2009-04-14
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。 本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。
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6.发明授权Anti-IL-22RA antibodies and binding partners and methods of using in inflammation 有权抗IL-22RA抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US07871616B2
公开(公告)日：2011-01-18
申请号：US12540084
申请日：2009-08-12
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。 本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。
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7.发明申请ANTI-IL-22RA ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权抗IL-22RA抗体和结合合作伙伴及其在炎症中的使用方法公开(公告)号：US20090220519A1
公开(公告)日：2009-09-03
申请号：US12423699
申请日：2009-04-14
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395 , A61P29/00 , A61P31/00
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。 本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。
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公开(公告)号：US08536309B2
公开(公告)日：2013-09-17
申请号：US13349380
申请日：2012-01-12
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret D. Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret D. Moore
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。 本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。
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9.发明授权Anti-IL-22RA antibodies and binding partners and methods of using in inflammation 有权抗IL-22RA抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US07537761B2
公开(公告)日：2009-05-26
申请号：US11256499
申请日：2005-10-21
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，减少，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。 本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。
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公开(公告)号：US07718172B2
公开(公告)日：2010-05-18
申请号：US11829765
申请日：2007-07-27
IPC分类号： A61K39/395 , C07K14/54 , C07K16/00 , C07K16/22
CPC分类号： C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/34
摘要： The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
摘要翻译： 本发明涉及阻断IL-TIF多肽分子的活性。 IL-TIF是涉及炎症过程和人类疾病的细胞因子。 本发明包括抗IL-TIF抗体和结合配偶体，以及在IL-TIF相关的人类炎性疾病中使用这样的抗体和结合伴侣拮抗IL-TIF的方法，以及其它用途。
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