专利检索 ap:("Wesley C. Van Voorhis" OR "Wilhelmus G. J. Hol" OR "Eric T. Larson" OR "Dustin James Maly" OR "Ethan Merritt" OR "Kayode K. Ojo") AND inv:"Eric T. Larson" 第 1 页

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发明授权
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases 有权

公开(公告)号：US09765037B2

公开(公告)日：2017-09-19

申请号：US13561896

申请日：2012-07-30

申请人： Wesley C. Van Voorhis , Wilhelmus G. J. Hol , Eric T. Larson , Dustin James Maly , Ethan Merritt , Kayode K. Ojo

发明人： Wesley C. Van Voorhis , Wilhelmus G. J. Hol , Eric T. Larson , Dustin James Maly , Ethan Merritt , Kayode K. Ojo

IPC分类号： C07D235/30 , C07D403/12 , C07D401/12 , C07D235/32 , C07D487/04

CPC分类号： C07D235/30 , C07D235/32 , C07D401/12 , C07D403/12 , C07D487/04 , Y02A50/488

摘要： Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R1, and R3 are defined herein.