公开(公告)号：US11724095B2

公开(公告)日：2023-08-15

申请号：US16801952

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M1/10 ,  A61M60/414 ,  A61M25/10 ,  A61M1/00 ,  A61M60/126

CPC分类号： A61M60/414 ,  A61M25/10 ,  A61M25/1002 ,  A61M1/85 ,  A61M60/126 ,  A61M2205/0216 ,  A61M2205/3331 ,  A61M2205/7536

摘要： The disclosure relates to devices and methods for the treatment of edema using a purge-free system. The invention provides devices and methods useful for treating edema by means of an indwelling catheter that is placed in a blood vessel of a patient and used to pump blood to cause a decrease in pressure at an outlet of a lymphatic duct. The catheter pumps blood by means of an impeller but is purge-free in that the catheter does not include a system for purging or flushing catheter components with a purge fluid. The purge-free catheter avoids blood-related mechanical complications such as clotting or thrombosis by means of an impermeable sleeve or shroud that protects moving parts of the impeller drive system.

公开(公告)号：US11660426B2

公开(公告)日：2023-05-30

申请号：US16801994

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M25/10

CPC分类号： A61M25/1018 ,  A61M25/10 ,  A61M2025/1022 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2210/125

摘要： The disclosure relates to devices and methods for the treatment of edema that uses an impeller with a balloon that may be mounted on the impeller housing. The invention provides devices and methods for treatment of edema that use an indwelling catheter with an impeller to lower pressure at an outlet of a lymphatic duct and a balloon on the impeller to guide and to restrict blood flow. The balloon restricts return flow from the jugular and guides that flow into the impeller cage. By funneling the flow into the impeller cage, a rate of flow down the vessel may be increased, resulting in a lateral pressure decrease effecting the lymphatic outlet. Because the lymphatic outlet is subject to a pressure decrease, fluids in the lymphatic system drain to the outlet and into the circulatory system.

公开(公告)号：US20240173542A1

公开(公告)日：2024-05-30

申请号：US18436332

申请日：2024-02-08

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M60/422 ,  A61M1/00 ,  A61M5/142 ,  A61M25/10 ,  A61M60/414

CPC分类号： A61M60/422 ,  A61M1/85 ,  A61M5/14276 ,  A61M60/414 ,  A61M25/1002

摘要： The disclosure relates to devices and methods for the treatment of edema which devices use an intravascular edema pump with an anticoagulant. The invention provides devices and methods for treating edema that use an indwelling catheter to place an impeller in a blood vessel of a patient, near an outlet of a lymphatic duct. Operating the impeller creates a local depression in blood pressure, which promotes drainage of lymph from the lymphatic system. The catheter is also used to release an anticoagulant such as heparin to wash and lubricate the impeller. Specifically, the anticoagulant inhibits clotting, hemolysis, or thrombosis from occurring and interfering with smooth operation of the impeller.

公开(公告)号：US20200268952A1

公开(公告)日：2020-08-27

申请号：US16802051

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston

IPC分类号： A61M1/10 ,  A61M1/12 ,  A61M1/00

摘要： The disclosure relates to devices and methods for the treatment of edema which devices use an intravascular edema pump with an anticoagulant. The invention provides devices and methods for treating edema that use an indwelling catheter to place an impeller in a blood vessel of a patient, near an outlet of a lymphatic duct. Operating the impeller creates a local depression in blood pressure, which promotes drainage of lymph from the lymphatic system. The catheter is also used to release an anticoagulant such as heparin to wash and lubricate the impeller. Specifically, the anticoagulant inhibits clotting, hemolysis, or thrombosis from occurring and interfering with smooth operation of the impeller.

公开(公告)号：US20200268951A1

公开(公告)日：2020-08-27

申请号：US16801994

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston

IPC分类号： A61M1/10 ,  A61M25/10

摘要： The disclosure relates to devices and methods for the treatment of edema that uses an impeller with a balloon that may be mounted on the impeller housing. The invention provides devices and methods for treatment of edema that use an indwelling catheter with an impeller to lower pressure at an outlet of a lymphatic duct and a balloon on the impeller to guide and to restrict blood flow. The balloon restricts return flow from the jugular and guides that flow into the impeller cage. By funneling the flow into the impeller cage, a rate of flow down the vessel may be increased, resulting in a lateral pressure decrease effecting the lymphatic outlet. Because the lymphatic outlet is subject to a pressure decrease, fluids in the lymphatic system drain to the outlet and into the circulatory system.

公开(公告)号：US20230364412A1

公开(公告)日：2023-11-16

申请号：US18213573

申请日：2023-06-23

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M60/414 ,  A61M25/10

CPC分类号： A61M60/414 ,  A61M25/1002 ,  A61M25/10 ,  A61M2205/0216 ,  A61M2205/3331 ,  A61M2205/7536 ,  A61M1/85

摘要： The disclosure relates to devices and methods for the treatment of edema using a purge-free system. The invention provides devices and methods useful for treating edema by means of an indwelling catheter that is placed in a blood vessel of a patient and used to pump blood to cause a decrease in pressure at an outlet of a lymphatic duct. The catheter pumps blood by means of an impeller but is purge-free in that the catheter does not include a system for purging or flushing catheter components with a purge fluid. The purge-free catheter avoids blood-related mechanical complications such as clotting or thrombosis by means of an impermeable sleeve or shroud that protects moving parts of the impeller drive system.

公开(公告)号：US20230347115A1

公开(公告)日：2023-11-02

申请号：US18213522

申请日：2023-06-23

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M25/10

CPC分类号： A61M25/10184 ,  A61M2205/3337

摘要： The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by\operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

公开(公告)号：US20200269025A1

公开(公告)日：2020-08-27

申请号：US16801982

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry Mccaffrey ,  Reed Williston

IPC分类号： A61M25/10

摘要： The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

公开(公告)号：US11931560B2

公开(公告)日：2024-03-19

申请号：US16802051

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M1/10 ,  A61M1/00 ,  A61M5/142 ,  A61M60/414 ,  A61M60/422 ,  A61M25/10

CPC分类号： A61M60/422 ,  A61M1/85 ,  A61M5/14276 ,  A61M60/414 ,  A61M25/1002

摘要： The disclosure relates to devices and methods for the treatment of edema which devices use an intravascular edema pump with an anticoagulant. The invention provides devices and methods for treating edema that use an indwelling catheter to place an impeller in a blood vessel of a patient, near an outlet of a lymphatic duct. Operating the impeller creates a local depression in blood pressure, which promotes drainage of lymph from the lymphatic system. The catheter is also used to release an anticoagulant such as heparin to wash and lubricate the impeller. Specifically, the anticoagulant inhibits clotting, hemolysis, or thrombosis from occurring and interfering with smooth operation of the impeller.

公开(公告)号：US20230347113A1

公开(公告)日：2023-11-02

申请号：US18138407

申请日：2023-04-24

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M25/10

CPC分类号： A61M25/1018 ,  A61M25/10 ,  A61M2205/3334 ,  A61M2210/125 ,  A61M2205/3341 ,  A61M2025/1022

摘要： The disclosure relates to devices and methods for the treatment of edema that uses an impeller with a balloon that may be mounted on the impeller housing. The invention provides devices and methods for treatment of edema that use an indwelling catheter with an impeller to lower pressure at an outlet of a lymphatic duct and a balloon on the impeller to guide and to restrict blood flow. The balloon restricts return flow from the jugular and guides that flow into the impeller cage. By funneling the flow into the impeller cage, a rate of flow down the vessel may be increased, resulting in a lateral pressure decrease effecting the lymphatic outlet. Because the lymphatic outlet is subject to a pressure decrease, fluids in the lymphatic system drain to the outlet and into the circulatory system.