公开(公告)号：US11945845B2

公开(公告)日：2024-04-02

申请号：US17595894

申请日：2020-05-30

申请人： Whitehead Institute for Biomedical Research

发明人： Ben Waldman ,  Sebastian Lourido

IPC分类号： A61K39/002 ,  A61P33/02 ,  A61P37/04 ,  C07K14/45 ,  C12N1/10 ,  C12N15/74 ,  A61K39/00

CPC分类号： C07K14/45 ,  A61K39/002 ,  A61P33/02 ,  A61P37/04 ,  C12N1/10 ,  C12N15/74 ,  A61K2039/52 ,  A61K2039/523 ,  A61K2039/585

摘要： The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection.

公开(公告)号：US20220235101A1

公开(公告)日：2022-07-28

申请号：US17595894

申请日：2020-05-30

申请人： Whitehead Institute for Biomedical Research

发明人： Ben Waldman ,  Sebastian Lourido

IPC分类号： C07K14/45 ,  C12N1/10 ,  A61K39/002 ,  A61P33/02 ,  C12N15/74 ,  A61P37/04

摘要： The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection.