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1.发明授权Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof 有权遗传工程化的P30抗原，改良抗原鸡尾酒及其用途公开(公告)号：US07824908B2
公开(公告)日：2010-11-02
申请号：US11860383
申请日：2007-09-24
CPC分类号： C07K14/45 , A61K39/00 , G01N33/56905 , G01N2333/45 , G01N2469/20 , Y10S435/975
摘要： The present invention relates to a genetically engineered P30 antigen and a combination or mixture of antigens (e.g., the genetically engineered P30 antigen and P35) that may be used in the detection of IgM and/or IgG antibodies to Toxoplasma gondii. Furthermore, the present invention also relates to methods of using this genetically engineered P30 antigen and combination of antigens, antibodies raised against this genetically engineered P30 antigen and combination of antigens, as well as kits and vaccines containing the genetically engineered P30 antigen and antigens present in the combination.
摘要翻译： 本发明涉及可用于检测弓形虫的IgM和/或IgG抗体的遗传工程化的P30抗原和抗原（例如，遗传工程化的P30抗原和P35）的组合或混合物。 此外，本发明还涉及使用这种遗传工程化的P30抗原和抗原组合，针对该遗传工程化的P30抗原产生的抗体和抗原组合的方法，以及含有遗传工程化的P30抗原的试剂盒和疫苗以及存在于 组合。
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2.发明授权Polynucleotides encoding coccidian parasite casein kinase I, a chemotherapeutic target for antiprotozoal agents 失效编码球虫寄生虫酪蛋白激酶I的多核苷酸，一种抗原虫药的化疗靶公开(公告)号：US07671181B2
公开(公告)日：2010-03-02
申请号：US10586374
申请日：2005-01-12
CPC分类号： C07K14/45 , C07K14/455 , C12N9/12
摘要： Isolated nucleic acid molecules encoding coccidian casein kinase I, CKI, enzymes from the species Eimeria tenella and Toxoplasma gondii are disclosed. The isolation of these coccidian CKI cDNA sequences results in the disclosure of purified forms of E. tenella and T. gondii CKI proteins, recombinant vectors and recombinant hosts which express coccidian CKI.
摘要翻译： 公开了编码球虫酪蛋白激酶I，CKI，来自艾美球虫（Eimeria tenella）和弓形虫（弓形虫）的酶的分离的核酸分子。 这些球虫CKI cDNA序列的分离导致纯化形式的E. tenella和弓形虫CKI蛋白，重组载体和表达球虫CKI的重组宿主的公开。
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公开(公告)号：US07611884B2
公开(公告)日：2009-11-03
申请号：US12138512
申请日：2008-06-13
CPC分类号： C07K14/45 , A61K39/00 , A61K48/00 , A61K2039/51 , C12N2799/021 , Y02A50/489 , Y10T436/143333
摘要： The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules and antibodies. Also included in the present invention are compositions comprising such proteins, nucleic acid molecules and/or antibodies, as well as the use of such compositions to inhibit oocyst shedding by cats due to infection with T. gondii. The present invention also includes the use of certain T. gondii-based antisera to identify such nucleic acid molecules and proteins, as well as nucleic acid molecules and proteins identified by such methods. The present invention also relates to novel methods for the detection of cysts and oocysts.
摘要翻译： 本发明涉及免疫原性弓形体蛋白，对弓形体核酸分子，包括编码这些蛋白质的那些和针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的组合物，以及这些组合物用于抑制由于感染弓形虫感染猫的卵囊脱落。 本发明还包括使用某些基于弓形虫的抗血清来鉴定此类核酸分子和蛋白质，以及通过这些方法鉴定的核酸分子和蛋白质。 本发明还涉及用于检测囊肿和卵囊的新颖方法。
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公开(公告)号：US20090042212A1
公开(公告)日：2009-02-12
申请号：US12104751
申请日：2008-04-17
IPC分类号： G01N33/53 , C07K7/00 , C07K14/00 , C12N15/11 , C12N15/00 , C12N1/20 , C12P21/04 , G01N33/566
CPC分类号： G01N33/6854 , C07K14/20 , C07K14/245 , C07K14/45 , C07K14/47 , C07K2319/70 , C12N15/62 , C12N2710/16122 , C12N2710/16134 , G01N2333/02 , G01N2333/035 , G01N2333/04 , G01N2333/045 , G01N2333/05 , G01N2333/19 , G01N2333/45
摘要： The present invention relates to fusion proteins: suitable as test antigens in the detection of infections with pathogens, particularly of primary infections with pathogens. Further, the invention relates to methods for detecting and differentially determining antibodies, particularly IgM antibodies resulting from an infection with a pathogenic organism. Furthermore, test reagents for carrying out these methods are provided.
摘要翻译： 本发明涉及融合蛋白：适合作为检测病原体感染的试验抗原，特别是病原体的初次感染。 此外，本发明涉及用于检测和差异测定抗体的方法，特别是由致病性生物体的感染产生的IgM抗体。 此外，提供了用于实施这些方法的测试试剂。
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公开(公告)号：US20080038250A1
公开(公告)日：2008-02-14
申请号：US11641084
申请日：2006-12-18
申请人： Igor Zlatkin , J. Justin McCormick
发明人： Igor Zlatkin , J. Justin McCormick
CPC分类号： C07K14/44 , A61K2039/55516 , C07K14/445 , C07K14/45 , C07K16/28 , Y02A50/412
摘要： The invention provides profilin-related immunomodulatory polypeptides and toll-like receptor agonists, as well as related pharmaceutical compositions and methods of treatment, useful for treating cancer and infectious disease.
摘要翻译： 本发明提供了profilin相关的免疫调节多肽和toll样受体激动剂，以及可用于治疗癌症和感染性疾病的相关药物组合物和治疗方法。
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公开(公告)号：US20070141076A1
公开(公告)日：2007-06-21
申请号：US11586694
申请日：2006-10-26
IPC分类号： A61K39/00 , G01N33/569 , C07H21/04 , C12N15/74 , G01N33/53 , A61K39/002 , C07K14/45 , C12N1/10
CPC分类号： C07K14/45 , A61K39/00 , C07K2319/00
摘要： The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite with sera of subjects who have been infected, using the phage display technique, and is characterised in that it uses the expression/exposure vector λKM4. The method allows also to identify antigen fragments related to the time of the infection.
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7.发明申请Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof 有权遗传工程化的P30抗原，改良抗原鸡尾酒及其用途公开(公告)号：US20040067239A1
公开(公告)日：2004-04-08
申请号：US10263153
申请日：2002-10-02
IPC分类号： G01N033/53 , G01N033/569 , C07H021/04 , A61K039/00 , A61K039/002 , C12N001/10 , C07K014/45 , C12N015/74
CPC分类号： C07K14/45 , A61K39/00 , G01N33/56905 , G01N2333/45 , G01N2469/20 , Y10S435/975
摘要： The present invention relates to a genetically engineered P30 antigen and a combination or mixture of antigens (e.g., the genetically engineered P30 antigen and P35) that may be used in the detection of IgM and/or IgG antibodies to Toxoplasma gondii. Furthermore, the present invention also relates to methods of using this genetically engineered P30 antigen and combination of antigens, antibodies raised against this genetically engineered P30 antigen and combination of antigens, as well as kits and vaccines containing the genetically engineered P30 antigen and antigens present in the combination.
摘要翻译： 本发明涉及可用于检测弓形虫的IgM和/或IgG抗体的遗传工程化的P30抗原和抗原（例如，遗传工程化的P30抗原和P35）的组合或混合物。 此外，本发明还涉及使用这种遗传工程化的P30抗原和抗原组合，针对该遗传工程化的P30抗原产生的抗体和抗原组合的方法，以及含有遗传工程化的P30抗原的试剂盒和疫苗以及存在于 组合。
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公开(公告)号：US20020172985A1
公开(公告)日：2002-11-21
申请号：US09848213
申请日：2001-05-04
IPC分类号： G01N033/53 , G01N033/569 , C07H021/04 , C12N015/74 , C12N001/19
CPC分类号： C07K14/45 , A61K38/00 , A61K39/00 , C07K2319/02 , Y10S435/962
摘要： The present invention provides a reagent for the detection or monitoring of a Toxoplasma gondii infection, which includes as a reactive substance a truncated Toxoplasma gondii P30 protein in which all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid 299 (SEQ ID NO: 1) has been deleted and all of the region of the native protein having the sequence starting with amino acid 31 and ending with the amino acid 299 (SEQ ID NO: 1) is contained. The present invention further describes methods of screening for anti-Toxoplasma antibodies in a biological sample
摘要翻译： 本发明提供了一种用于检测或监测弓形虫感染的试剂，其包括作为活性物质的截短弓形弓形体P30蛋白，其中天然蛋白质的所有疏水C末端区域以位于其后的氨基酸开始 已经缺失氨基酸299（SEQ ID NO：1），并且包含具有以氨基酸31开始并以氨基酸299（SEQ ID NO：1）结尾的序列的天然蛋白质的所有区域。 本发明还描述了在生物样品中筛选抗弓形体抗体的方法
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公开(公告)号：US06420540B1
公开(公告)日：2002-07-16
申请号：US09185818
申请日：1998-11-04
IPC分类号： C07H2102
CPC分类号： C07K14/45 , A61K39/00 , Y10S435/975 , Y10S530/822
摘要： The present invention relates to peptides immunoreactive with antibodies to Toxoplasma gondii, nucleic acid sequences encoding these peptides, recombinant vector molecules, comprising these nucleic acid sequences, host cells transformed with the recombinant vector molecule, immunochemical reagents comprising the peptides or antibodies directed against the peptides, a test kit for the detection of T. gondii infections as well as a vaccine for the protection against T. gondii infections. In particular the present invention provides peptides comprising part of the amino acid sequence as shown in SEQ ID No.: 1. preferred embodiment of the present invention are peptides comprising at least part of the amino acid sequence shown in SEQ ID No.: 3 or 5. It has been found that the peptides according to the present invention are particularly suitable for diagnosing T. gondii infected humans.
摘要翻译： 本发明涉及与弓形体的抗体免疫反应的肽，编码这些肽的核酸序列，包含这些核酸序列的重组载体分子，用重组载体分子转化的宿主细胞，包含针对肽的肽或抗体的免疫化学试剂 ，用于检测弓形虫感染的测试试剂盒以及用于保护抗弓形虫感染的疫苗。特别地，本发明提供了包含SEQ ID NO：1所示的部分氨基酸序列的肽。 本发明的优选实施方案是包含SEQ ID No .: 3或5所示氨基酸序列的至少一部分的肽。已经发现根据本发明的肽特别适用于诊断弓形虫感染的人 。
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公开(公告)号：US06372897B1
公开(公告)日：2002-04-16
申请号：US09165422
申请日：1998-10-02
IPC分类号： C07H2102
摘要： The invention relates to a polypeptide capable of reacting specifically with an anti-Toxoplasma gondii P30 protein antibody, and comprising a peptide sequence, in which any succession of 6 contiguous amino acids exhibits at most 67 % homology with the peptide sequence of said P30 protein, identified by SEQ ID No.1, or comprising a sequence derived from said peptide sequence, and the applications of this polypeptide especially for detecting a Toxoplasma gondii infection, in a biological sample.
摘要翻译： 本发明涉及能够与抗弓形体弓形体P30蛋白抗体特异性反应的多肽，并且包含肽序列，其中任何连续的6个连续氨基酸与所述P30蛋白的肽序列具有最多67％的同源性， 由SEQ ID No.1鉴定，或包含源自所述肽序列的序列，以及该多肽的应用，特别是用于检测生物样品中的弓形虫感染。
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