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公开(公告)号：US07723367B2
公开(公告)日：2010-05-25
申请号：US12051565
申请日：2008-03-19
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin C. h. Hirst , Bigin Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin C. h. Hirst , Bigin Li
IPC分类号： A61K31/41 , C07D257/00
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US20120329772A1
公开(公告)日：2012-12-27
申请号：US13544387
申请日：2012-07-09
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： C07D257/06 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/4439 , A61K31/4709 , C07D409/12 , C07D403/12 , A61K31/497 , A61K31/4155 , A61K31/435 , C07D405/12 , A61K31/496 , C07D491/048 , A61K31/4355 , C07D417/12 , A61K31/427 , A61K31/506 , C07D401/14 , A61K31/444 , C07D413/14 , A61K31/551 , A61K31/55 , A61K31/553 , C07D487/04 , A61P29/00 , A61P25/28 , A61P25/24 , A61P25/00 , A61K31/41
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US20080171733A1
公开(公告)日：2008-07-17
申请号：US12051565
申请日：2008-03-19
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： A61K31/397 , A61K31/41 , A61K31/5377 , A61K31/4427 , A61K31/47 , A61K31/497 , A61P29/00 , A61P25/00 , A61K31/5513 , A61K31/496 , A61K31/445 , A61K31/426 , A61K31/506
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X 7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1， R 2，R 3，R 4，R 4和R 5如本文所定义。 描述。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US08546374B2
公开(公告)日：2013-10-01
申请号：US13544387
申请日：2012-07-09
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biquin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biquin C. Li
IPC分类号： C07D257/06 , C07D413/12 , C07D401/12 , C07D409/12 , C07D403/12 , C07D405/12 , C07D491/048 , C07D417/12 , C07D401/14 , C07D413/14 , C07D487/04 , A61K31/41 , A61K31/5377 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/435 , A61K31/4155 , A61K31/496 , A61K31/4355 , A61K31/427 , A61K31/506 , A61K31/444 , A61K31/551 , A61K31/55 , A61K31/553 , A61P29/00 , A61P25/28 , A61P25/24 , A61P25/00
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US07704997B1
公开(公告)日：2010-04-27
申请号：US11221333
申请日：2005-09-07
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： A61K31/551 , A61K31/496 , A61K31/5377 , A61K31/4545 , A61K31/444 , A61K31/4439 , A61K31/4709 , C07D243/08 , C07D413/14 , C07D401/14 , C07D215/12 , C07D213/02 , C07D401/12
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US08217067B2
公开(公告)日：2012-07-10
申请号：US11120718
申请日：2005-04-29
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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7.发明申请公开(公告)号：US20100093814A1
公开(公告)日：2010-04-15
申请号：US12274105
申请日：2008-11-19
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , C07D277/28 , A61P25/00
CPC分类号： C07D277/46 , C07D277/28 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/08
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在具体实施方案中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a，R x和n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号：US08546583B2
公开(公告)日：2013-10-01
申请号：US11755434
申请日：2007-05-30
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , A61K31/427 , C07D417/06 , C07D417/14 , C07D277/44
CPC分类号： C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在说明书中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a和（R x）n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号：US07875639B2
公开(公告)日：2011-01-25
申请号：US11755884
申请日：2007-05-31
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07D498/04 , C07D493/04 , C07D417/06 , C07D277/46 , C07D277/60 , C07D277/82
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US09006275B2
公开(公告)日：2015-04-14
申请号：US12970480
申请日：2010-12-16
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/429 , C07D513/04 , C07D277/46 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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