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公开(公告)号：US08895592B2
公开(公告)日：2014-11-25
申请号：US12639173
申请日：2009-12-16
申请人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
发明人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
IPC分类号： A61K31/426 , C07D277/08
CPC分类号： C07D417/12 , C07D277/46 , C07D513/04
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L1, A1, R1g, z, R2, R3, and R4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中L1，A1，R1g，z，R2，R3和R4如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08173687B2
公开(公告)日：2012-05-08
申请号：US12539120
申请日：2009-08-11
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/433 , C07D285/12
CPC分类号： C07D261/14 , C07D285/135 , C07D407/06 , C07D417/06
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中Y，X1，X2，X3，R1和R2如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100041720A1
公开(公告)日：2010-02-18
申请号：US12539120
申请日：2009-08-11
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/41 , C07D285/135 , C07D231/10 , A61K31/415 , C07D263/30 , A61K31/421
CPC分类号： C07D261/14 , C07D285/135 , C07D407/06 , C07D417/06
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中Y，X1，X2，X3，R1和R2如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100216760A1
公开(公告)日：2010-08-26
申请号：US12639173
申请日：2009-12-16
申请人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
发明人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
IPC分类号： A61K31/427 , C07D417/12 , C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D417/12 , C07D277/46 , C07D513/04
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L1, A1, R1g, z, R2, R3, and R4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中L1，A1，R1g，z，R2，R3和R4如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08865753B2
公开(公告)日：2014-10-21
申请号：US12970435
申请日：2010-12-16
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： A61K31/426 , C07D277/08 , C07D417/12 , C07D513/04 , C07D277/46 , C07D417/06
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20110086832A1
公开(公告)日：2011-04-14
申请号：US12970435
申请日：2010-12-16
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/429 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P37/00 , A61P9/00 , A61P35/00 , A61P11/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20080242654A1
公开(公告)日：2008-10-02
申请号：US12051538
申请日：2008-03-19
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： C07D277/18 , A61K31/426 , A61K31/397 , A61K31/4436 , C07D417/02 , A61K31/5377 , A61K31/4535 , A61P11/00 , A61P9/00 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及式（I）的含噻唑基的化合物，其中R 1，R 2，R 3，R 4， / SUB>，L 2＆gt;和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US07875640B2
公开(公告)日：2011-01-25
申请号：US12051538
申请日：2008-03-19
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： A61K31/426 , C07D277/08
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100069348A1
公开(公告)日：2010-03-18
申请号：US12560893
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/397 , C07D405/02 , A61K31/4155 , A61P29/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61P3/04 , A61P11/00 , A61P3/10 , A61P9/00 , C07D417/02 , A61K31/454
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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公开(公告)号：US08859596B2
公开(公告)日：2014-10-14
申请号：US12560893
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/433 , C07D285/12 , C07D405/12 , C07D413/14 , C07D413/12 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D285/135 , C07D231/40
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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