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公开(公告)号:US5800986A
公开(公告)日:1998-09-01
申请号:US456346
申请日:1995-06-01
CPC分类号: C07K14/005 , C12N15/85 , C12N2740/14022 , C12N2740/16322 , C12N2800/108 , C12N2830/00 , C12N2830/55 , C12N2840/44
摘要: Assays screened for compounds that inhibit tat transactivation of the HIV (HTLV-III) LTR are taught. The assay involves tranfecting a cell line containing the tat gene by a vector containing a gene under the control of an HIV-1 LTR, adding the compound to be screened and determining the effect of the compound by looking at the effect of tat as measured by the expression of the gene under the control of the HIV LTR.
摘要翻译: 针对抑制HIV转录激活(HTLV-III)LTR的化合物进行了筛选。 该测定包括通过含有在HIV-1LTR控制下的基因的载体来染色含有tat基因的细胞系,加入待筛选的化合物,并通过观察tat的作用来确定化合物的作用,通过 该基因在HIV LTR控制下的表达。
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公开(公告)号:US5801056A
公开(公告)日:1998-09-01
申请号:US131898
申请日:1993-10-05
申请人: William Alan Haseltine , Craig A. Rosen , Joseph Gerald Sodroski , Flossie Wong-Staal , Suresh K. Arya
发明人: William Alan Haseltine , Craig A. Rosen , Joseph Gerald Sodroski , Flossie Wong-Staal , Suresh K. Arya
CPC分类号: C07K14/005 , C12N15/85 , C12N2740/14022 , C12N2740/16322 , C12N2800/108 , Y10S930/221
摘要: Nucleic acid encoding a functional HTLV-III/LAV (HIV-1) protein having trans-activating ability, and expression vectors comprising this nucleic acid are described.
摘要翻译: 描述了编码具有反式激活能力的功能性HTLV-III / LAV(HIV-1)蛋白质的核酸和包含该核酸的表达载体。
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