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公开(公告)号：US5801056A
公开(公告)日：1998-09-01
申请号：US131898
申请日：1993-10-05
申请人： William Alan Haseltine , Craig A. Rosen , Joseph Gerald Sodroski , Flossie Wong-Staal , Suresh K. Arya
发明人： William Alan Haseltine , Craig A. Rosen , Joseph Gerald Sodroski , Flossie Wong-Staal , Suresh K. Arya
CPC分类号： C07K14/005 , C12N15/85 , C12N2740/14022 , C12N2740/16322 , C12N2800/108 , Y10S930/221
摘要： Nucleic acid encoding a functional HTLV-III/LAV (HIV-1) protein having trans-activating ability, and expression vectors comprising this nucleic acid are described.
摘要翻译： 描述了编码具有反式激活能力的功能性HTLV-III / LAV（HIV-1）蛋白质的核酸和包含该核酸的表达载体。
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公开(公告)号：US5800986A
公开(公告)日：1998-09-01
申请号：US456346
申请日：1995-06-01
CPC分类号： C07K14/005 , C12N15/85 , C12N2740/14022 , C12N2740/16322 , C12N2800/108 , C12N2830/00 , C12N2830/55 , C12N2840/44
摘要： Assays screened for compounds that inhibit tat transactivation of the HIV (HTLV-III) LTR are taught. The assay involves tranfecting a cell line containing the tat gene by a vector containing a gene under the control of an HIV-1 LTR, adding the compound to be screened and determining the effect of the compound by looking at the effect of tat as measured by the expression of the gene under the control of the HIV LTR.
摘要翻译： 针对抑制HIV转录激活（HTLV-III）LTR的化合物进行了筛选。 该测定包括通过含有在HIV-1LTR控制下的基因的载体来染色含有tat基因的细胞系，加入待筛选的化合物，并通过观察tat的作用来确定化合物的作用，通过 该基因在HIV LTR控制下的表达。
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公开(公告)号：US08216569B2
公开(公告)日：2012-07-10
申请号：US11980495
申请日：2007-10-31
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
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公开(公告)号：US08168205B2
公开(公告)日：2012-05-01
申请号：US12635794
申请日：2009-12-11
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US08143026B2
公开(公告)日：2012-03-27
申请号：US12534585
申请日：2009-08-03
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben , Paul A. Moore , Jason B. Bock , David LaFleur
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben , Paul A. Moore , Jason B. Bock , David LaFleur
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。
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公开(公告)号：US20110112177A1
公开(公告)日：2011-05-12
申请号：US12943202
申请日：2010-11-10
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K31/7052 , C07H21/00 , C12N15/63 , C12N1/00 , C12N5/00 , C12P21/00 , C12N15/74 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , A61P9/12 , A61P9/10 , A61P25/00
CPC分类号： C07K14/705
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。
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公开(公告)号：US07932361B2
公开(公告)日：2011-04-26
申请号：US12268263
申请日：2008-11-10
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US07914789B2
公开(公告)日：2011-03-29
申请号：US11801040
申请日：2007-05-07
IPC分类号： A61K39/395
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20110033470A1
公开(公告)日：2011-02-10
申请号：US12831336
申请日：2010-07-07
申请人： Yi Li , Craig A. Rosen
发明人： Yi Li , Craig A. Rosen
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C07K14/705 , C07K16/28 , G01N33/566 , C12Q1/68 , A61K38/02 , C07K2/00 , A61P43/00
CPC分类号： C07K14/723 , A61K38/00 , C07K14/705
摘要： A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the G-protein coupled receptor. Also disclosed are assays for detecting mutations in the nucleic acid sequence encoding the G-protein coupled receptor.
摘要翻译： 公开了人G-蛋白偶联受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽鉴定此类多肽的拮抗剂和激动剂的方法。 拮抗剂和激动剂可用于治疗性地抑制或刺激G蛋白偶联受体。 还公开了用于检测编码G蛋白偶联受体的核酸序列中的突变的测定法。
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公开(公告)号：US20110009312A1
公开(公告)日：2011-01-13
申请号：US12836447
申请日：2010-07-14
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。
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