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公开(公告)号：US20070244092A1
公开(公告)日：2007-10-18
申请号：US11735528
申请日：2007-04-16
申请人： William Brown , Ziping Liu , Daniel Page , Zena Qadoumi , Sanjay Srivastava , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
发明人： William Brown , Ziping Liu , Daniel Page , Zena Qadoumi , Sanjay Srivastava , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4184 , C07D413/02 , C07D403/02
CPC分类号： C07D405/06 , C07D401/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3和R 4， 如本说明书中所定义，以及制备包括化合物在内的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US07615642B2
公开(公告)日：2009-11-10
申请号：US11735528
申请日：2007-04-16
申请人： William Brown , Ziping Liu , Daniel Page , Zena Qadoumi , Sanjay Srivastava , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
发明人： William Brown , Ziping Liu , Daniel Page , Zena Qadoumi , Sanjay Srivastava , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
IPC分类号： A61K31/4184 , C07D403/14
CPC分类号： C07D405/06 , C07D401/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2，R3和R4如本说明书中所定义，以及包括所述化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20110086853A1
公开(公告)日：2011-04-14
申请号：US12575673
申请日：2009-10-08
申请人： William Brown , Ziping Liu , Daniel Page , Zena Qadoumi , Sanjay Srivastava , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
发明人： William Brown , Ziping Liu , Daniel Page , Zena Qadoumi , Sanjay Srivastava , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
IPC分类号： A61K31/4184 , C07D405/06 , C07D405/14 , C07D413/14 , A61K31/5377 , A61K31/454 , A61P25/00 , A61P25/22 , A61P35/00 , A61P25/16 , A61P25/28 , A61P9/00 , A61P1/00
CPC分类号： C07D405/06 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2，R3和R4如本说明书中所定义，以及包括所述化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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4.发明申请BENZIMIDAZOLE DERIVATIVES WHICH ARE TO BE USED AS ANTAGONIST FOR THE CB1-RECEPTOR 审中-公开被用作CB1受体拮抗剂的苯并咪唑衍生物公开(公告)号：US20100305140A1
公开(公告)日：2010-12-02
申请号：US12303643
申请日：2007-06-11
申请人： William Brown , Daniel Page , Sanjay Srivastava , Christopher Walpole , Zhong-Yong Wei , Hua Yang
发明人： William Brown , Daniel Page , Sanjay Srivastava , Christopher Walpole , Zhong-Yong Wei , Hua Yang
IPC分类号： A61K31/496 , C07D403/10 , C07D401/12 , A61K31/4184 , A61K31/454 , A61P1/00
CPC分类号： C07D413/14 , C07D235/08 , C07D401/06 , C07D403/06 , C07D417/14
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein X, A, R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中X，A，R 1，R 2，R 3和R 4如说明书中所定义，以及盐和药物组合物，包括化合物的制备。 它们可用于治疗，特别是治疗疼痛。
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5.发明申请Novel 3-Bicyclocarbonylaminopyridine-2-Carboxamides or 3-Bicyclocarbonylaminopyrazine-2-Carboxamides 审中-公开新型3-双环羰基氨基吡啶-2-羧酰胺或3-双羰基氨基吡嗪-2-羧酰胺公开(公告)号：US20090181968A1
公开(公告)日：2009-07-16
申请号：US12094334
申请日：2006-11-22
申请人： Kosrat Amin , Johan Broddefalk , Yantao Chen , Karolina Nilsson , Claire Milburn , Helene Desfosses , Ziping Liu , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
发明人： Kosrat Amin , Johan Broddefalk , Yantao Chen , Karolina Nilsson , Claire Milburn , Helene Desfosses , Ziping Liu , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
IPC分类号： A61K31/5377 , C07D401/10 , C07D405/14 , A61K31/4439 , A61K31/497 , C07D413/14 , C07D405/12 , A61K31/4433 , A61K31/496 , C07D401/12 , A61K31/4709 , C07D409/14 , A61K31/4436 , C07D417/12 , A61K31/4375 , C07D413/12 , A61P29/00
CPC分类号： C07D213/82 , C07D213/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I) [Chemical formula should be inserted here. Please see paper copy] as well as pharmaceutically acceptable salts and pharmaceutical compositions including the compounds are prepared or thereof: wherein, A1, A2, R1, R2, R3, R4, and R5 and n are as defined in the specification. The compounds of formula (I) are useful in therapy.
摘要翻译： 本发明涉及式（I）化合物[化学式应在此插入。 请参阅纸本]以及药学上可接受的盐和药物组合物，包括化合物的制备或其制备：其中，A1，A2，R1，R2，R3，R4和R5以及n如说明书中所定义。 式（I）化合物可用于治疗。
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公开(公告)号：US20070225292A1
公开(公告)日：2007-09-27
申请号：US11569315
申请日：2005-05-20
申请人： Kosrat Amin , Johan Broddefalk , Helene Desfosses , Emma Evertsson , Ziping Liu , Claire Milburn , Karolina Nilsson , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
发明人： Kosrat Amin , Johan Broddefalk , Helene Desfosses , Emma Evertsson , Ziping Liu , Claire Milburn , Karolina Nilsson , Maxime Tremblay , Christopher Walpole , Zhong-yong Wei , Hua Yang
IPC分类号： A61K31/44 , A61K31/4965 , C07D213/81 , C07D241/24
CPC分类号： C07D213/81 , A61K31/44 , A61K31/4965 , C07D213/82 , C07D241/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, n and A are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， ，n和A如说明书中所定义，以及制备包括所述化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20090018116A1
公开(公告)日：2009-01-15
申请号：US11569295
申请日：2005-05-20
申请人： Shujuan Jin , Ziping Liu , Claire Milburn , Miroslaw Tomaszewski , Christopher Walpole , Zhong-Yong Wei , Hua Yang
发明人： Shujuan Jin , Ziping Liu , Claire Milburn , Miroslaw Tomaszewski , Christopher Walpole , Zhong-Yong Wei , Hua Yang
IPC分类号： A61K31/55 , A61K31/40 , C07D207/09 , C07C237/34 , A61P1/00 , A61P35/00 , A61K31/166 , C07D223/04
CPC分类号： C07C237/42 , C07C237/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/09 , C07D211/26 , C07D215/48 , C07D217/16 , C07D237/28 , C07D265/30 , C07D295/13 , C07D295/192 , C07D295/32 , C07D307/79 , C07D309/14 , C07D317/46 , C07D319/08 , C07D319/12 , C07D321/10 , C07D413/06 , C07D471/08
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2，R3，R4和n如本说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20070219254A1
公开(公告)日：2007-09-20
申请号：US11569326
申请日：2005-05-20
申请人： Ziping Liu , Christopher Walpole , Zhong-Yong Wei , Hua Yang
发明人： Ziping Liu , Christopher Walpole , Zhong-Yong Wei , Hua Yang
IPC分类号： A61K31/44 , A61K31/4433 , A61P25/00 , C07D213/89 , C07D405/12
CPC分类号： C07D213/81 , A61K31/44 , A61K31/4433 , C07D213/89 , C07D405/12
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， ，m和n如说明书中所定义，以及制备包括所述化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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9.发明申请Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof 审中-公开苯并咪唑衍生物，含有它们的组合物，其制备及其用途公开(公告)号：US20070082899A1
公开(公告)日：2007-04-12
申请号：US10572929
申请日：2004-09-24
申请人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
发明人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4184 , C07D413/02 , C07D403/02
CPC分类号： C07D405/06 , C07D235/08 , C07D401/06 , C07D405/14 , C07D413/12
摘要： Compounds of Formulae (IA), (IB) or pharmaceutically acceptable salts thereof; wherein Het, X1, R1, R2, R3, R3a and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（IA），（IB）或其药学上可接受的盐的化合物; 其中Het，X 1，R 1，R 2，R 3，R 3， 本说明书中所定义的那样，以及制备包括化合物在内的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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10.发明申请Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I 有权化合物，含有它们的组合物及其制备方法I公开(公告)号：US20060264490A1
公开(公告)日：2006-11-23
申请号：US11419603
申请日：2006-05-22
申请人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
发明人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184
CPC分类号： C07D235/08 , C07D235/10 , C07D405/06
摘要： Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， >，R 5和G如说明书中所定义，以及制备包括化合物在内的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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