公开(公告)号：US20090264791A1

公开(公告)日：2009-10-22

申请号：US12425567

申请日：2009-04-17

Applicant: William D. Gregory ,  Christopher Gregory

Inventor： William D. Gregory ,  Christopher Gregory

IPC: A61B5/053

CPC classification number: A61B5/0536 ,  A61B5/053 ,  A61B5/4312 ,  A61B6/502 ,  A61B2562/0209 ,  A61B2562/046

Abstract: A system and method for detecting cancerous tissue in a subject is provided. More specifically, the present invention provides a system and method for non-invasively identifying cancerous regions in breast tissue. The system includes a sensor system, a drive system, and a processor. The sensor system includes a sensor plate and, similarly, the drive system includes a drive plate. A time-varying voltage is applied to the drive plate and induced currents are subsequently measured by the sensor plate. Signals indicative of an induced current are then acquired and analyzed by the processor to determine the spatial location of anomalous regions. Subsequently, the anomalous regions are characterized as either cancerous or non-cancerous.

Abstract translation: 提供了一种用于检测受试者中的癌组织的系统和方法。 更具体地，本发明提供了用于非侵入性地鉴定乳腺组织中的癌性区域的系统和方法。 该系统包括传感器系统，驱动系统和处理器。 传感器系统包括传感器板，并且类似地，驱动系统包括驱动板。 时变电压被施加到驱动板，感应电流随后由传感器板测量。 然后由处理器获取并分析指示感应电流的信号，以确定异常区域的空间位置。 随后，异常区域被表征为癌性或非癌性。

公开(公告)号：US20090253193A1

公开(公告)日：2009-10-08

申请号：US12417075

申请日：2009-04-02

Applicant: William D. Gregory

Inventor： William D. Gregory

IPC: C12M1/34

CPC classification number: G01N33/4836 ,  Y10T436/2575

Abstract: A device for characterizing ex vivo tissue employs a set of independent electrodes that may be used to scan the tissue by moving a voltage gradient across the tissue surface acquiring impedance spectrographs that may be mapped to an image.

Abstract translation: 用于表征离体组织的装置采用一组独立电极，其可以用于通过移动组织表面上的电压梯度来扫描组织，获得可映射到图像的阻抗光谱仪。

公开(公告)号：US20130211280A1

公开(公告)日：2013-08-15

申请号：US13835380

申请日：2013-03-15

Applicant: William D. Gregory ,  Christopher W W. Gregory ,  John R. Shell

Inventor： William D. Gregory ,  Christopher W W. Gregory ,  John R. Shell

IPC: A61B5/053 ,  A61B5/00

CPC classification number: A61B5/053 ,  A61B5/0536 ,  A61B5/7203

Abstract: A method for characterizing tissues within a subject as cancerous or non-cancerous includes determining the electrical properties of the subject. The electrical properties of the subject are fit to a model and a specific range of a set of characteristic frequencies of each tissue is then calculated. Each tissue is finally characterized as cancerous or non-cancerous if the specific range of the set of characteristic frequencies inside or outside, respectively, a pre-determined spread of characteristic frequencies.

Abstract translation: 用于将受试者内的组织表征为癌性或非癌性的方法包括确定受试者的电学性质。 受试者的电学性质适合于模型，然后计算每组织的一组特征频率的特定范围。 如果特定频率集合的特定范围内部或外部分别是特定频率的预定扩散，则每个组织最终被表征为癌性或非癌性。

公开(公告)号：US06763263B2

公开(公告)日：2004-07-13

申请号：US09916821

申请日：2001-07-26

Applicant: Christopher William Gregory ,  William D. Gregory

Inventor： Christopher William Gregory ,  William D. Gregory

IPC: A61B500

CPC classification number: G01V3/088

Abstract: An electrical property imaging system includes an array of sensors placed around an object to measure the surface charges thereon as a sinusoidal voltage is applied thereacross. The resulting distribution of charges inside the object are calculated using a stored charge correlation matrix. Electrical property images are produced from the internal charge distribution image.

Abstract translation: 电气性能成像系统包括放置在物体周围的传感器阵列，以在其上施加正弦电压来测量其上的表面电荷。 使用存储的电荷相关矩阵计算所得到的对象内的电荷分布。 电气特性图像由内部电荷分布图像产生。

公开(公告)号：US06522910B1

公开(公告)日：2003-02-18

申请号：US09508250

申请日：2000-03-08

Applicant: William D. Gregory

Inventor： William D. Gregory

IPC: A61B505

CPC classification number: G01N27/24 ,  A61B5/0536 ,  A61B5/7257

Abstract: Enhanced information on the electrical properties of the subregions of a sample is generated by an enhanced tomography (EPET) apparatus connected to a tomographic device, wherein the EPET apparatus holds a voltage constant and measures the electrical current of the sample inserted within the EPET apparatus. A matching medium is applied to the sample such that when the sample is placed within an electromagnetic field generated by the EPET apparatus, the matching medium contacts the segmented sensor plates of the EPET apparatus and allows the detection of the net total charges Q on the surface of the sample. The EPET apparatus uses these net total charges Q in the calculation of the additional information on the electrical properties of the sample by using the scale factor method or the iterative correction method. The EPET apparatus and method has application in the medical imaging field, such as in the obtaining of enhanced dielectric constant and conductivity electrical properties values related to the imaging of the interior of the human body, e.g., in the determination of whether tissue is cancerous, dead or healthy.

Abstract translation: 关于样本的子区域的电特性的增强信息由连接到断层摄影装置的增强层析成像（EPET）装置产生，其中EPET装置保持电压常数并测量插入在EPET装置内的样本的电流。 将匹配的介质施加到样品，使得当样品放置在由EPET设备产生的电磁场内时，匹配介质接触EPET设备的分段传感器板，并允许检测表面上的净总电荷Q 的样品。 通过使用比例因子法或迭代校正方法，EPET装置使用这些净总电荷Q来计算样本的电特性的附加信息。 EPET装置和方法在医学成像领域中的应用，例如在获得与人体内部成像有关的增强的介电常数和导电性电特性值时，例如在确定组织是否癌变， 死亡或健康

公开(公告)号：US09066671B2

公开(公告)日：2015-06-30

申请号：US12425567

申请日：2009-04-17

Applicant: William D. Gregory ,  Christopher Gregory

Inventor： William D. Gregory ,  Christopher Gregory

IPC: A61B5/05 ,  A61B5/053 ,  A61B5/00 ,  A61B6/00

CPC classification number: A61B5/0536 ,  A61B5/053 ,  A61B5/4312 ,  A61B6/502 ,  A61B2562/0209 ,  A61B2562/046

Abstract: A system and method for detecting cancerous tissue in a subject is provided. More specifically, the present invention provides a system and method for non-invasively identifying cancerous regions in breast tissue. The system includes a sensor system, a drive system, and a processor. The sensor system includes a sensor plate and, similarly, the drive system includes a drive plate. A time-varying voltage is applied to the drive plate and induced currents are subsequently measured by the sensor plate. Signals indicative of an induced current are then acquired and analyzed by the processor to determine the spatial location of anomalous regions. Subsequently, the anomalous regions are characterized as either cancerous or non-cancerous.

Abstract translation: 提供了一种用于检测受试者中的癌组织的系统和方法。 更具体地，本发明提供了用于非侵入性地鉴定乳腺组织中的癌性区域的系统和方法。 该系统包括传感器系统，驱动系统和处理器。 传感器系统包括传感器板，并且类似地，驱动系统包括驱动板。 时变电压被施加到驱动板，感应电流随后由传感器板测量。 然后由处理器获取并分析指示感应电流的信号，以确定异常区域的空间位置。 随后，异常区域被表征为癌性或非癌性。

公开(公告)号：US07627362B2

公开(公告)日：2009-12-01

申请号：US10700876

申请日：2003-11-04

Applicant: Christopher William Gregory ,  William D. Gregory

Inventor： Christopher William Gregory ,  William D. Gregory

IPC: A61B5/05

CPC classification number: A61B5/0064 ,  A61B5/0536 ,  A61B5/1077 ,  A61B5/7257

Abstract: An electrical parameter imaging apparatus and method includes the acquisition of a charge distribution pattern on an array of electrodes that surround an object being imaged. In addition the exterior boundary, or contours of the object is measured by an array of light beams and associated light sensors. The contour measurement is employed to provide a first estimate of the object geometry needed to compute an electrical parameter image from the acquired charge distribution pattern.

Abstract translation: 电参数成像装置和方法包括在围绕被成像对象的电极阵列上获取电荷分布图案。 此外，物体的外部边界或轮廓通过光束阵列和相关联的光传感器来测量。 使用轮廓测量来提供从获取的电荷分布图案计算电参数图像所需的对象几何的第一估计。

公开(公告)号：US4370611A

公开(公告)日：1983-01-25

申请号：US28452

申请日：1979-04-09

Applicant: William D. Gregory ,  Luigi Morelli

Inventor： William D. Gregory ,  Luigi Morelli

IPC: G01N27/22 ,  G01N27/24 ,  G01R27/26

CPC classification number: G01R27/2623 ,  G01N27/228 ,  G01N33/227

Abstract: The non-linear conductance and capacitance characteristics of electrically non-homogenous materials over a given frequency range are used to identify and analyze such materials.

Abstract translation: 在给定频率范围内的非均匀材料的非线性电导和电容特性用于识别和分析这些材料。

公开(公告)号：US20110270066A1

公开(公告)日：2011-11-03

申请号：US13099068

申请日：2011-05-02

Applicant: William D. Gregory

Inventor： William D. Gregory

IPC: A61B5/053

CPC classification number: A61B5/053

Abstract: A device and method for accurately characterizing tissue impedance employs multiple electrodes at a plurality of separation distances to cancel the effects of front end loading leakage currents and electrode polarization to improve the accuracy of sensitive impedance measurements used to identify cancerous tissues. These measurements may be automated over a range of frequencies.

Abstract translation: 用于准确表征组织阻抗的装置和方法采用多个间隔距离处的多个电极来消除前端负载泄漏电流和电极极化的影响，以提高用于识别癌组织的敏感阻抗测量的精度。 这些测量可以在一定频率范围内自动化。

公开(公告)号：US4881025A

公开(公告)日：1989-11-14

申请号：US248639

申请日：1988-09-26

Applicant: William D. Gregory

Inventor： William D. Gregory

IPC: G01N27/22 ,  G01R27/26

CPC classification number: G01R27/2605 ,  G01N27/221 ,  G01N27/226

Abstract: Packaged materials are tested in a capacitive sensor which has plates whose spacing can be accurately adjusted, and whose plates are segmented so that selected segments can be employed. An a.c. voltage is applied across the capacitive plates at accurately known amplitude, phase, and frequency for a number of frequencies. A ratio bridge is tied to each number of frequencies. A ratio bridge is tied to each of the segments and provides outputs that reflect the a.c. voltage and current, both capacitive and ohmic. A zero-crossing detection method or time domain method can be employed to provide precise amplitude and phase, or a quadrature or phase-sensitive detection method can provide amplitude and phase, or a quadrature or phase-sensitive detection method can provide amplitude and phase of the a.c. current through each segment. Values of capacitance, conductance, frequency dependence of capacitance, and frequency dependent of conductance are compared to stored values of a number of known objects of the target class.

Abstract translation: 封装材料在电容传感器中进行测试，电容式传感器具有能够精确调整间隔的板，并且其板被分段以便可以使用所选择的段。 一个 对于多个频率，以精确地已知的幅度，相位和频率在电容板两端施加电压。 比例桥接与每个频率数量相关联。 比例桥与每个段相关联，并提供反映交流的输出。 电压和电流，电容和欧姆。 可以采用过零检测方法或时域方法提供精确的幅度和相位，或者正交或相敏检测方法可以提供幅度和相位，或正交或相敏检测方法可以提供幅度和相位 ac 当前通过每个段。 将电容，电导率，电容的频率依赖性和与电导的频率相关的值与目标类的多个已知对象的存储值进行比较。