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1.发明授权Compositions for ameliorating cell proliferative disorders and methods of making and using them 有权用于改善细胞增殖性疾病的组合物及其制备和使用方法公开(公告)号：US08598313B2
公开(公告)日：2013-12-03
申请号：US13581288
申请日：2011-03-11
IPC分类号： A61K38/12
CPC分类号： C07D513/18 , C07D513/08
摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of FIG. 1) and apratoxin G (compound 7 of FIG. 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
摘要翻译： 在替代实施方案中，本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体，衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。 在替代实施方案中，本发明提供包含阿曲毒素F（图1的化合物6）和阿曲毒素G（图1的化合物7）及其立体异构体，衍生物和类似物的药物组合物和制剂。 在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或改善可以通过减少或抑制细胞生长（例如病理，不受控制或不期望的细胞生长）而改善的疾病或病症的量施用， 例如癌症或转移瘤，或任何疾病或病症（例如过敏）或具有过度增殖细胞生长成分的感染。
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2.发明申请COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM 有权用于改善细胞增殖性疾病的组合物及其制备和使用它们的方法公开(公告)号：US20130045925A1
公开(公告)日：2013-02-21
申请号：US13581288
申请日：2011-03-11
CPC分类号： C07D513/18 , C07D513/08
摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of FIG. 1) and apratoxin G (compound 7 of FIG. 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
摘要翻译： 在替代实施方案中，本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体，衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。 在替代实施方案中，本发明提供包含阿曲毒素F（图1的化合物6）和阿曲毒素G（图1的化合物7）及其立体异构体，衍生物和类似物的药物组合物和制剂。 在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或改善可以通过减少或抑制细胞生长（例如病理，不受控制或不期望的细胞生长）而改善的疾病或病症的量施用， 例如癌症或转移瘤，或任何疾病或病症（例如过敏）或具有过度增殖细胞生长成分的感染。
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