利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.029 秒)

    Curacin A analogs exhibiting antiproliferative activity against cells
    2.
    发明授权
    Curacin A analogs exhibiting antiproliferative activity against cells 失效
    表现出对细胞抗增殖活性的库拉霉素A类似物

    公开(公告)号：US6057348A

    公开(公告)日：2000-05-02

    申请号：US115582

    申请日：1998-07-14

    申请人： William H. Gerwick ,  John R. Falck ,  Brian L. Marquez

    发明人： William H. Gerwick ,  John R. Falck ,  Brian L. Marquez

    IPC分类号： C07D277/24 ,  C07D417/06 ,  A61K31/427

    CPC分类号： C07D417/06 ,  C07D277/24

    摘要： Isomers of a cytotoxic compound isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The compound, termed "curacin D", exhibits substantial biological activity against proliferating cells. Analogs of curacin A also are described, as are formulations that include curacin D and the curacin A analogs. The curacins A-D and analogs of curacin A exhibit antimitotic behavior.

    摘要翻译： 公开了从海洋蓝杆菌Lyngbya大理石分离和纯化的细胞毒性化合物的异构体。 称为“凝乳酶D”的化合物对增殖细胞表现出显着的生物活性。 也描述了Curacin A的类似物，还包括包含Curacin D和Curacin A类似物的制剂。 曲安素A-D和曲美素A的类似物显示抗有丝分裂的行为。

    COMPOSITIONS AND METHODS FOR INHIBITING PROTEASES
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING PROTEASES 有权
    用于抑制蛋白质的组合物和方法

    公开(公告)号：US20140248333A1

    公开(公告)日：2014-09-04

    申请号：US14131681

    申请日：2012-07-12

    申请人： William H. Gerwick ,  Alban R. Pereira-Badilla ,  Tara Byrum ,  Frederick A. Valeriote ,  Michael Kenneth Gilson ,  Andrew Fenley ,  Bradley S. Moore ,  Andrew Kale ,  Hosana M. Debonsi

    发明人： William H. Gerwick ,  Alban R. Pereira-Badilla ,  Tara Byrum ,  Frederick A. Valeriote ,  Michael Kenneth Gilson ,  Andrew Fenley ,  Bradley S. Moore ,  Andrew Kale ,  Hosana M. Debonsi

    IPC分类号： C07K5/083

    CPC分类号： C07K5/0808 ,  A61K31/336 ,  C07K5/06052

    摘要： In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which include racemic mixtures or racemates, isomers, stereoisomers, diastereoisomers, derivatives and analogs, and methods for making and using them. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate an infection, disease or condition that can be ameliorated, treated, prevented or reversed by partially or completely inhibiting a chymotrypsin-like protease or a proteasome activity, including e.g., a retroviral infection such as human immunodeficiency virus-1 (HIV-1) infection, an immune disorder, a neurodegenerative disease or condition, or a cancer such as a myeloma or multiple myeloma, an adenocarcinoma such as a lung adenocarcinoma, a pancreatic cancer, a B-cell related cancer, and lymphomas such as non-Hodgkin's lymphoma.

    摘要翻译： 特别地，在替代实施方案中，本发明提供包含一系列环氧酮化合物的药物化合物和制剂，其包括外消旋混合物或外消旋体，异构体，立体异构体，非对映异构体，衍生物和类似物，以及制备和使用它们的方法。 在替代实施方案中，将本发明的药物组合物和制剂以足以治疗，预防，逆转和/或改善可被改善，治疗，预防或逆转的感染，疾病或病症的量施用于有需要的个体 部分或完全抑制胰凝乳蛋白酶样蛋白酶或蛋白酶体活性，包括例如逆转录病毒感染如人免疫缺陷病毒-1（HIV-1）感染，免疫疾病，神经变性疾病或病症，或癌症如 骨髓瘤或多发性骨髓瘤，腺癌如肺腺癌，胰腺癌，B细胞相关癌症，淋巴瘤如非霍奇金淋巴瘤。

    Scytonemin and methods of using thereof
    5.
    发明授权
    Scytonemin and methods of using thereof 失效
    Scytonemin及其使用方法

    公开(公告)号：US06495588B2

    公开(公告)日：2002-12-17

    申请号：US09960314

    申请日：2001-09-24

    申请人： Robert S. Jacobs ,  Lisa A. Marshall ,  William H. Gerwick ,  Christopher Stevenson

    发明人： Robert S. Jacobs ,  Lisa A. Marshall ,  William H. Gerwick ,  Christopher Stevenson

    IPC分类号： A61K4338

    CPC分类号： A61K31/404 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/491

    摘要： Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

    摘要翻译： 公开了具有scytoneman骨架的化合物，例如scytonemin，及其使用方法。 公开了使用具有Scytoneman骨架的化合物抑制，调节，减弱或预防细胞周期进程，细胞增殖，激酶活性或诱导细胞凋亡的方法。 还公开了治疗，预防或抑制与细胞周期进程，细胞增殖，激酶活性，组织增生或血管发生如癌症或炎性疾病相关的疾病和病症的方法。

    Method for the recovery of 12-(S)-hydroxyeicosapentaenoic acid from the red alga murrayella periclados
    7.
    发明授权
    Method for the recovery of 12-(S)-hydroxyeicosapentaenoic acid from the red alga murrayella periclados 失效
    从红藻mur lad属中回收12-（S） - 羟基二十碳五烯酸的方法

    公开(公告)号：US4810424A

    公开(公告)日：1989-03-07

    申请号：US107616

    申请日：1987-10-09

    申请人： William H. Gerwick ,  Matthew W. Bernart

    发明人： William H. Gerwick ,  Matthew W. Bernart

    IPC分类号： C11B1/10

    CPC分类号： C11B1/10

    摘要： 12-(S)-hydroxyeicosapentaenoic acid is chemically extracted from the red alga Murrayella periclados. Fresh or frozen quantities of Murrayella periclados are first macerated and combined with a 2:1 mixture of chloroform and methanol. This results in an organic fraction containing lipid isolates. After filtration to remove extraneous solids, the organic fraction is evaporated to produce a tar. The tar contains 12-(S)-HEPE which is further purified as desired.

    摘要翻译： 从红藻Murrayella periclados中化学提取12-（S） - 羟基二十碳五烯酸。 首先将新鲜或冷冻的Murrayella periclados浸泡并与氯仿和甲醇的2:1混合物混合。 这导致含有脂质分离物的有机部分。 过滤除去外来固体后，蒸发有机级分以产生焦油。 焦油含有12-（S）-HEPE，其根据需要进一步纯化。

    Compositions for ameliorating cell proliferative disorders and methods of making and using them
    8.
    发明授权
    Compositions for ameliorating cell proliferative disorders and methods of making and using them 有权
    用于改善细胞增殖性疾病的组合物及其制备和使用方法

    公开(公告)号：US08598313B2

    公开(公告)日：2013-12-03

    申请号：US13581288

    申请日：2011-03-11

    申请人： William H. Gerwick ,  Kevin Tidgewell ,  Frederick A. Valeriote

    发明人： William H. Gerwick ,  Kevin Tidgewell ,  Frederick A. Valeriote

    IPC分类号： A61K38/12

    CPC分类号： C07D513/18 ,  C07D513/08

    摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of FIG. 1) and apratoxin G (compound 7 of FIG. 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.

    摘要翻译： 在替代实施方案中，本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体，衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。 在替代实施方案中，本发明提供包含阿曲毒素F（图1的化合物6）和阿曲毒素G（图1的化合物7）及其立体异构体，衍生物和类似物的药物组合物和制剂。 在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或改善可以通过减少或抑制细胞生长（例如病理，不受控制或不期望的细胞生长）而改善的疾病或病症的量施用， 例如癌症或转移瘤，或任何疾病或病症（例如过敏）或具有过度增殖细胞生长成分的感染。

    COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM
    9.
    发明申请
    COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM 有权
    用于改善细胞增殖性疾病的组合物及其制备和使用它们的方法

    公开(公告)号：US20130045925A1

    公开(公告)日：2013-02-21

    申请号：US13581288

    申请日：2011-03-11

    申请人： William H. Gerwick ,  Kevin Tidgewell ,  Frederick A. Valeriote

    发明人： William H. Gerwick ,  Kevin Tidgewell ,  Frederick A. Valeriote

    IPC分类号： A61K38/07 ,  C12N5/071 ,  A61P35/04 ,  A61P29/00 ,  C07K5/10 ,  A61P35/00

    CPC分类号： C07D513/18 ,  C07D513/08

    摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of FIG. 1) and apratoxin G (compound 7 of FIG. 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.

    摘要翻译： 在替代实施方案中，本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体，衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。 在替代实施方案中，本发明提供包含阿曲毒素F（图1的化合物6）和阿曲毒素G（图1的化合物7）及其立体异构体，衍生物和类似物的药物组合物和制剂。 在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或改善可以通过减少或抑制细胞生长（例如病理，不受控制或不期望的细胞生长）而改善的疾病或病症的量施用， 例如癌症或转移瘤，或任何疾病或病症（例如过敏）或具有过度增殖细胞生长成分的感染。