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公开(公告)号：US3947491A
公开(公告)日：1976-03-30
申请号：US501004
申请日：1974-09-03
申请人： William Kelly, deceased , by Monica Kelly, representative , by John Kelly, representative , Alfred Halpern
发明人： William Kelly, deceased , by Monica Kelly, representative , by John Kelly, representative , Alfred Halpern
IPC分类号： C07C91/00
摘要： Choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds of the formula, ##SPC1##Wherein Me represents the sodium, potassium or lithium ion and R represents the sulfite, bisulfite, metabisulfite, dithionate, hydrosulfite and hyposulfite groups are described. Said compounds are stable and inhibit the formation of color in pharmaceutical preparations containing the same. The method for the preparation of choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds, and pharmaceutical dosage forms containing the same are disclosed together with a method for their use to inhibit color formation.
摘要翻译： 胆碱水杨酸亚油酸酯和水杨酸胆碱碱金属亚硫酸盐化合物，其中Me代表钠，钾或锂离子，R代表亚硫酸盐，亚硫酸氢盐，偏亚硫酸氢盐，连二硫酸盐，连二亚硫酸盐和亚硫酸氢盐基团。 所述化合物稳定并且抑制含有该化合物的药物制剂中的颜色形成。 公开了用于制备水杨酸胆碱酯亚胺酸酯和水杨酸胆碱盐碱金属亚硫酸盐化合物的方法，以及含有它们的药物剂型及其用于抑制颜色形成的方法。
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公开(公告)号：US4098813A
公开(公告)日：1978-07-04
申请号：US753396
申请日：1976-12-22
CPC分类号： A61K47/02
摘要： Choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds of the formula, ##STR1## WHEREIN Me represents the sodium, potassium or lithium ion and R represents the sulfite, bisulfite, metabisulfite, dithionate, hydrosulfite and hyposulfite groups are described. Said compounds are stable and inhibit the formation of color in pharmaceutical preparations containing the same. The method for the preparation of choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds, and pharmaceutical dosage forms containing the same are disclosed together with a method for their use to inhibit color formation.
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公开(公告)号：US4001311A
公开(公告)日：1977-01-04
申请号：US625783
申请日：1975-10-24
申请人： William Kelly, deceased , by Monica Kelly, personal representative , by John Kelly, personal representative , Alfred Halpern
发明人： William Kelly, deceased , by Monica Kelly, personal representative , by John Kelly, personal representative , Alfred Halpern
CPC分类号： A61K47/20
摘要： Choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds of the formula, ##STR1## wherein Me represents the sodium, potassium or lithium ion and R represents the sulfite, bisulfite metabisulfite, dithionate, hydrosulfite and hyposulfite groups are described. Said compounds are stable and inhibit the formation of color in pharmaceutical preparations containing the same. The method for the preparation of choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds, and pharmaceutical dosage forms containing the same are disclosed together with a method for their use to inhibit color formation.
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公开(公告)号：US4147776A
公开(公告)日：1979-04-03
申请号：US880840
申请日：1978-02-23
CPC分类号： A61K9/0014 , A61K47/02 , Y10S514/973
摘要： Choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds of the formula; ##STR1## WHEREIN Me represents the sodium, potassium, or lithium ion and R represents the sulfite, bisulfite, metabisulfite, dithionate, hydrosulfite, and hyposulfite groups are described. Said compounds are stable and inhibit the formation of color on pharmaceutical preparations containing the same. The method for the preparation of cholin-salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds, and pharmaceutical dosage forms containing the same are disclosed together with a method for their use to inhibit color formation.
摘要翻译： 水杨酸胆碱亚油酸酯和水杨酸胆碱碱金属亚硫酸盐化合物; 其中Me表示钠离子，钾离子或锂离子，R表示亚硫酸盐，亚硫酸氢盐，偏亚硫酸氢盐，连二硫酸盐，连二亚硫酸盐和亚硫酸氢盐基团。 所述化合物是稳定的并且抑制在含有该化合物的药物制剂上形成颜色。 公开了制备亚硝酸胆碱水杨酸酯和水杨酸胆碱盐碱金属亚硫酸盐化合物的方法，以及含有它们的药物剂型及其用于抑制颜色形成的方法。
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