公开(公告)号：US20080292657A1

公开(公告)日：2008-11-27

申请号：US11678596

申请日：2007-02-24

申请人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi-Ngole

发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi-Ngole

IPC分类号： A61K39/00 ,  C12N15/11 ,  C12N7/00 ,  A61P37/00 ,  C12Q1/70 ,  C12N15/00

CPC分类号： C12Q1/701 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12Q1/70

摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

摘要翻译： 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。