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    PRIMATE T-LYMPHOTROPIC VIRUSES
    1.
    发明申请
    PRIMATE T-LYMPHOTROPIC VIRUSES 有权
    主要的T淋巴细菌病毒

    公开(公告)号：US20080292657A1

    公开(公告)日：2008-11-27

    申请号：US11678596

    申请日：2007-02-24

    申请人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi-Ngole

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi-Ngole

    IPC分类号： A61K39/00 ,  C12N15/11 ,  C12N7/00 ,  A61P37/00 ,  C12Q1/70 ,  C12N15/00

    CPC分类号： C12Q1/701 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12Q1/70

    摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

    摘要翻译： 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。

    PRIMATE T-LYMPHOTROPIC VIRUSES
    2.
    发明申请
    PRIMATE T-LYMPHOTROPIC VIRUSES 有权
    主要的T淋巴细菌病毒

    公开(公告)号：US20100317034A1

    公开(公告)日：2010-12-16

    申请号：US12829125

    申请日：2010-07-01

    申请人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    IPC分类号： G01N33/53 ,  C07K14/005 ,  C07K16/08

    CPC分类号： C12Q1/701 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12Q1/70

    摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

    摘要翻译： 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。

    Primate T-lymphotropic viruses
    3.
    发明授权
    Primate T-lymphotropic viruses 有权
    灵长类T淋巴细胞病毒

    公开(公告)号：US07794998B2

    公开(公告)日：2010-09-14

    申请号：US11678596

    申请日：2007-02-24

    申请人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    IPC分类号： C12N15/09 ,  C12N7/00 ,  A61K39/00

    CPC分类号： C12Q1/701 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12Q1/70

    摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

    摘要翻译： 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。

    Primate T-lymphotropic viruses
    4.
    发明授权
    Primate T-lymphotropic viruses 有权
    灵长类T淋巴细胞病毒

    公开(公告)号：US08541221B2

    公开(公告)日：2013-09-24

    申请号：US12829125

    申请日：2010-07-01

    申请人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    IPC分类号： C12N7/00 ,  C12N7/04

    CPC分类号： C12Q1/701 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12Q1/70

    摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

    摘要翻译： 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。

    Simian T-cell lymphotropic virus
    5.
    发明授权
    Simian T-cell lymphotropic virus 有权
    猿猴T细胞淋巴细胞病毒

    公开(公告)号：US08663968B2

    公开(公告)日：2014-03-04

    申请号：US12600995

    申请日：2008-05-20

    申请人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  David M. Sintasath

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  David M. Sintasath

    IPC分类号： C12N15/09 ,  C12N7/00 ,  A61K39/00

    CPC分类号： C07K14/005 ,  C07K16/1036 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  G01N33/56983

    摘要： Disclosed are the simian T-cell lymphotropic virus type 3 subtype D (STLV-3 subtype D), isolated nucleic acid molecules encoding STLV-3 subtype D polypeptides, such as STLV-3 subtype D envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting STLV-3 subtype D, for example by detecting a STLV-3 subtype D nucleic acid or polypeptide in the sample. Accordingly, probes, primers, and antibodies for use in detecting STLV-3 subtype D nucleic acids or polypeptides are disclosed. Therapeutic compositions which included isolated nucleic acid molecules encoding a STLV-3 subtype D polypeptides or isolated polypeptides encoded by such nucleic acid molecules are also disclosed.

    摘要翻译： 公开了3型亚型T型细胞淋巴细胞病毒（STLV-3亚型D），编码STLV-3亚型D多肽的分离的核酸分子，例如STLV-3亚型D包膜，蛋白酶，聚合酶，tax，rex， 和衣壳多肽，由这种核酸编码的分离的多肽。 还公开了用于检测STLV-3亚型D的方法，例如通过检测样品中的STLV-3亚型D核酸或多肽。 因此，公开了用于检测STLV-3亚型D核酸或多肽的探针，引物和抗体。 还公开了包含编码STLV-3亚型D多肽的分离的核酸分子或由这种核酸分子编码的分离的多肽的治疗组合物。

    Isolation of a human retrovirus
    7.
    发明授权
    Isolation of a human retrovirus 有权
    人类逆转录病毒的分离

    公开(公告)号：US06800475B1

    公开(公告)日：2004-10-05

    申请号：US10018627

    申请日：2001-12-14

    申请人： William M. Switzer ,  Walid Heneine ,  Paul A. Sandstrom ,  Thomas M. Folks

    发明人： William M. Switzer ,  Walid Heneine ,  Paul A. Sandstrom ,  Thomas M. Folks

    IPC分类号： C12N700

    CPC分类号： C07K14/005 ,  A61K35/00 ,  A61K48/00 ,  A61K2039/5256 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/17021 ,  C12N2740/17022 ,  C12N2740/17043

    摘要： The present invention comprises compositions and methods comprising a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates. Importantly, the methods and compositions of the present invention comprising the spumavirus and including antibodies to the spumavirus, can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The present invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

    摘要翻译： 本发明包括组合物和方法，其包含从人分离的真菌病毒。 更具体地，将本发明的真菌病毒与暴露于非人灵长类动物的人分离。 重要的是，包含该真菌病毒并包括针对该病毒的抗体的本发明的方法和组合物可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。 本发明还可用于治疗由于快速分裂的细胞的存在和用于重组活病毒疫苗接种的人的病症。

    Methods for sensitive detection of reverse transcriptase
    9.
    发明授权
    Methods for sensitive detection of reverse transcriptase 失效
    敏感检测逆转录酶的方法

    公开(公告)号：US6136534A

    公开(公告)日：2000-10-24

    申请号：US123012

    申请日：1998-07-27

    申请人： Walid Heneine ,  Thomas M. Folks ,  William M. Switzer ,  Shinji Yamamoto

    发明人： Walid Heneine ,  Thomas M. Folks ,  William M. Switzer ,  Shinji Yamamoto

    IPC分类号： C12N15/09 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  C12R1/92 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/702

    摘要： The present invention provides a method for detecting the presence of a retrovirus in a biological sample comprising the steps of: a) contacting the biological sample with an RNA template and a complementary DNA primer under conditions whereby the RNA template and the DNA primer will anneal and a DNA strand will be synthesized as an extension from the DNA primer if reverse transcriptase is present in the sample; b) amplifying the synthesized DNA; and c) detecting the amplification of the synthesized DNA, the amplification of the synthesized DNA indicating the presence of reverse transcriptase in the biological sample, thus indicating the presence of a retrovirus in the biological sample.

    摘要翻译： 本发明提供了一种用于检测生物样品中逆转录病毒的存在的方法，包括以下步骤：a）在RNA模板和DNA引物将退火的条件下使生物样品与RNA模板和互补DNA引物接触， 如果样品中存在逆转录酶，DNA链将作为DNA引物的延伸进行合成; b）扩增合成的DNA; 和c）检测合成DNA的扩增，合成DNA的扩增，表明在生物样品中存在逆转录酶，从而表明生物样品中存在逆转录病毒。