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1.发明申请PYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE FOR INHIBITING 11-BETA-HYDROXYSTEROID DEHYDROGENASE 审中-公开吡啶-3-羧酰胺化合物及其用于抑制11-羟基脱氢酶脱氢酶的用途公开(公告)号：US20100022589A1
公开(公告)日：2010-01-28
申请号：US12375302
申请日：2007-07-26
IPC分类号： A61K31/4545 , C07D213/60 , A61K31/44 , A61K31/443 , C07D405/12 , C07D401/12 , A61K31/444 , A61P3/00
CPC分类号： C07D213/82
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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公开(公告)号：US08673938B2
公开(公告)日：2014-03-18
申请号：US12541565
申请日：2009-08-14
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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公开(公告)号：US20090306075A1
公开(公告)日：2009-12-10
申请号：US12541565
申请日：2009-08-14
IPC分类号： A61K31/5377 , C07D413/02 , A61P3/04 , A61P3/10
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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公开(公告)号：US07964618B2
公开(公告)日：2011-06-21
申请号：US11928744
申请日：2007-10-30
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11β和HSD1的用途，其制备方法和包含它们的药物组合物。
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公开(公告)号：US20080269288A1
公开(公告)日：2008-10-30
申请号：US11928744
申请日：2007-10-30
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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公开(公告)号：US20090264401A1
公开(公告)日：2009-10-22
申请号：US12427170
申请日：2009-04-21
申请人： Adrian Liam GILL , Andrew Leach , Martin Packer , James Stewart Scott , Pernilla Sorme , John Gibbin Swales , Paul Robert Owen Whittamore
发明人： Adrian Liam GILL , Andrew Leach , Martin Packer , James Stewart Scott , Pernilla Sorme , John Gibbin Swales , Paul Robert Owen Whittamore
IPC分类号： A61K31/5377 , C07D413/04 , A61K31/505 , C07D239/28 , C07D239/38 , A61P3/10 , C07D413/14 , A61K31/554 , C07D419/04
CPC分类号： C07D239/42 , C07D239/28 , C07D239/38 , C07D239/47 , C07D239/48 , C07D239/557 , C07D239/58 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04
摘要： A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 式（I）的化合物及其药学上可接受的盐，其中所述可变基团定义在其内; 还描述了其用于抑制11betaHSD1的用途，其制备方法和包含它们的药物组合物。
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![4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic Acid - 465](/abs-image/US/2011/03/10/US20110060022A1/abs.jpg.150x150.jpg)
7.发明申请4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic Acid - 465 审中-公开4- [4-（2-金刚烷基氨基甲酰基）-5-叔丁基 - 吡唑-1-基]苯甲酸465公开(公告)号：US20110060022A1
公开(公告)日：2011-03-10
申请号：US12741589
申请日：2008-11-05
IPC分类号： A61K31/415 , C07D231/14 , A61P3/10 , A61P3/04
CPC分类号： C07D231/14
摘要： 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid and pharmaceutically-acceptable salts thereof and a particular crystalline form of the Agent (Form 1); their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 4- [4-（2-金刚烷基氨基甲酰基）-5-叔丁基 - 吡唑-1-基]苯甲酸及其药学上可接受的盐和特定结晶形式的试剂（形式1）; 还描述了它们在抑制11β和HSD1中的用途，其制备方法和包含它们的药物组合物。
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