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1.发明申请PYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE FOR INHIBITING 11-BETA-HYDROXYSTEROID DEHYDROGENASE 审中-公开吡啶-3-羧酰胺化合物及其用于抑制11-羟基脱氢酶脱氢酶的用途公开(公告)号：US20100022589A1
公开(公告)日：2010-01-28
申请号：US12375302
申请日：2007-07-26
IPC分类号： A61K31/4545 , C07D213/60 , A61K31/44 , A61K31/443 , C07D405/12 , C07D401/12 , A61K31/444 , A61P3/00
CPC分类号： C07D213/82
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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公开(公告)号：US20090221663A1
公开(公告)日：2009-09-03
申请号：US12259562
申请日：2008-10-28
IPC分类号： A61K31/4155 , C07D405/12
CPC分类号： C07D231/18 , C07D231/14 , C07D403/06 , C07D405/12
摘要： A compound of Formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 式（I）的化合物及其药学上可接受的盐，其中定义可变基团; 还描述了其用于抑制11betaHSD1的用途，其制备方法和包含它们的药物组合物。
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公开(公告)号：US20090264401A1
公开(公告)日：2009-10-22
申请号：US12427170
申请日：2009-04-21
申请人： Adrian Liam GILL , Andrew Leach , Martin Packer , James Stewart Scott , Pernilla Sorme , John Gibbin Swales , Paul Robert Owen Whittamore
发明人： Adrian Liam GILL , Andrew Leach , Martin Packer , James Stewart Scott , Pernilla Sorme , John Gibbin Swales , Paul Robert Owen Whittamore
IPC分类号： A61K31/5377 , C07D413/04 , A61K31/505 , C07D239/28 , C07D239/38 , A61P3/10 , C07D413/14 , A61K31/554 , C07D419/04
CPC分类号： C07D239/42 , C07D239/28 , C07D239/38 , C07D239/47 , C07D239/48 , C07D239/557 , C07D239/58 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04
摘要： A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 式（I）的化合物及其药学上可接受的盐，其中所述可变基团定义在其内; 还描述了其用于抑制11betaHSD1的用途，其制备方法和包含它们的药物组合物。
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公开(公告)号：US08673938B2
公开(公告)日：2014-03-18
申请号：US12541565
申请日：2009-08-14
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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![Crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic acid 471](/abs-image/US/2011/05/31/US07951833B2/abs.jpg.150x150.jpg)
5.发明授权Crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic acid 471 失效4- [4-（2-金刚烷基氨基甲酰基）-5-叔丁基 - 吡唑-1-基]苯甲酸471的结晶形式公开(公告)号：US07951833B2
公开(公告)日：2011-05-31
申请号：US12364949
申请日：2009-02-03
申请人： Gary Peter Tomkinson , Martin John Packer , James Stewart Scott , Paul Robert Owen Whittamore , Andrew Stocker
发明人： Gary Peter Tomkinson , Martin John Packer , James Stewart Scott , Paul Robert Owen Whittamore , Andrew Stocker
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/14
摘要： New crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 4- [4-（2-金刚烷基氨基甲酰基）-5-叔丁基 - 吡唑-1-基]苯甲酸的新结晶形式; 还描述了它们在抑制11β和HSD1中的用途，其制备方法和包含它们的药物组合物。
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公开(公告)号：US20110065706A1
公开(公告)日：2011-03-17
申请号：US12879631
申请日：2010-09-10
申请人： Alan Martin Birch , Roger John Butlin , David Stephen Clarke , Andrew Leach , Philip Alexander MacFaul , Charles John O'Donnell , James Stewart Scott , Paul Robert Owen Whittamore , Dan Anders Broo , Öjvind Percy Davidsson , Kjell Erik Johansson , Hanna De La Motte
发明人： Alan Martin Birch , Roger John Butlin , David Stephen Clarke , Andrew Leach , Philip Alexander MacFaul , Charles John O'Donnell , James Stewart Scott , Paul Robert Owen Whittamore , Dan Anders Broo , Öjvind Percy Davidsson , Kjell Erik Johansson , Hanna De La Motte
IPC分类号： A61K31/5377 , C07D403/04 , A61K31/506 , C07D403/14 , C07D401/14 , C07D413/14 , C07D487/08 , C07D405/14 , A61P3/04 , A61P3/10
CPC分类号： C07D239/47 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/08 , C07D487/08
摘要： A compound of formula I or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as GPR119 modulators, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, and pharmaceutical compositions containing them.
摘要翻译： 式I化合物或其药学上可接受的盐，制备此类化合物的方法，其用作GPR119调节剂，其治疗用途的方法，特别是治疗肥胖症和糖尿病，以及含有它们的药物组合物。
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公开(公告)号：US20090306075A1
公开(公告)日：2009-12-10
申请号：US12541565
申请日：2009-08-14
IPC分类号： A61K31/5377 , C07D413/02 , A61P3/04 , A61P3/10
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11betaHSD1，其制备方法和包含它们的药物组合物的用途。
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公开(公告)号：US08344016B2
公开(公告)日：2013-01-01
申请号：US12878416
申请日：2010-09-09
IPC分类号： A61K31/415 , C07D321/02
CPC分类号： C07D231/18 , C07D231/14 , C07D403/06 , C07D405/12
摘要： A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 式（I）的化合物及其药学上可接受的盐，其中所述可变基团定义在其内; 还描述了它们在抑制11β和HSD1中的用途，其制备方法和包含它们的药物组合物。
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公开(公告)号：US20110224273A1
公开(公告)日：2011-09-15
申请号：US12878416
申请日：2010-09-09
IPC分类号： A61K31/4155 , C07D231/14 , A61K31/415 , C07D231/18 , C07D403/06 , A61P3/00
CPC分类号： C07D231/18 , C07D231/14 , C07D403/06 , C07D405/12
摘要： A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 式（I）的化合物及其药学上可接受的盐，其中所述可变基团定义在其内; 还描述了它们在抑制11β和HSD1中的用途，其制备方法和包含它们的药物组合物。
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公开(公告)号：US07964618B2
公开(公告)日：2011-06-21
申请号：US11928744
申请日：2007-10-30
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
摘要翻译： 式（I）化合物：其中定义可变基团; 描述了其用于抑制11β和HSD1的用途，其制备方法和包含它们的药物组合物。
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