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1.发明申请CANCER TREATMENT METHODS USING CADHERIN ANTAGONISTS IN COMBINATION WITH ANTICANCER AGENTS 审中-公开癌症治疗方法使用CADHERIN拮抗剂与抗原药物联合公开(公告)号：US20080194467A1
公开(公告)日：2008-08-14
申请号：US11863127
申请日：2007-09-27
IPC分类号： A61K38/12 , A61K31/197 , A61P35/00
CPC分类号： A61K45/06 , A61K31/195 , A61K31/337 , A61K31/4188 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/2013 , A61K38/212 , A61K38/50 , A61K2300/00
摘要： Improved methods for treating cancer which employ combinations comprising cadherin antagonists with certain anticancer agents or treatments are provided. The methods of the invention involve the administration of cadherin antagonist before, concurrent with, or after, administration of an anticancer agent or treatment and provide unexpectedly improved therapeutic benefit in the treatment of tumors growing in vivo.
摘要翻译： 提供了改进的使用包含钙粘着蛋白拮抗剂的组合与某些抗癌剂或治疗剂来治疗癌症的方法。 本发明的方法包括在施用抗癌剂或治疗之前，同时或之后施用钙粘蛋白拮抗剂，并且在治疗体内生长的肿瘤中提供意想不到的改善的治疗益处。
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2.发明申请METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS 审中-公开用于联合5-FU和5-FU PRODRUGS的DPD抑制剂的施用方法公开(公告)号：US20130184232A1
公开(公告)日：2013-07-18
申请号：US13686240
申请日：2012-11-27
IPC分类号： A61K31/513
CPC分类号： A61K31/513 , A61K31/505 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
摘要翻译： 提供了用于改进DPD抑制剂与5-FU和/或5-FU前药组合的给药和给药方法，包括首先向有需要的患者施用基本上消除酶活性的DPD抑制剂，然后施用5-FU 或5-FU前药，其中5-FU或5-FU前药的水平在患者体内基本上超过DPD抑制剂。
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3.发明授权Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs 有权给予DPD抑制剂与5-FU和5-FU前药组合的方法公开(公告)号：US08318756B2
公开(公告)日：2012-11-27
申请号：US11294643
申请日：2005-12-05
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/505 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
摘要翻译： 提供了用于改进DPD抑制剂与5-FU和/或5-FU前药组合的给药和给药方法，包括首先向有需要的患者施用基本上消除酶活性的DPD抑制剂，然后施用5-FU 或5-FU前药，其中5-FU或5-FU前药的水平在患者体内基本上超过DPD抑制剂。
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4.发明申请CHEMICALLY MODIFIED CYCLIC PEPTIDES CONTAINING CELL ADHESION RECOGNITION (CAR) SEQUENCES AND USES THEREFOR 审中-公开含有细胞粘附识别（CAR）序列及其用途的化学修饰循环肽公开(公告)号：US20090131306A1
公开(公告)日：2009-05-21
申请号：US12139270
申请日：2008-06-13
申请人： Mukur Gupta , Brian Huber , William Paul Peters
发明人： Mukur Gupta , Brian Huber , William Paul Peters
摘要： Chemically modified cyclic peptides comprising cell adhesion recognition (CAR) sequences are provided having improved properties, such as improved stability. Also provided are methods of making and using same.
摘要翻译： 提供了包含细胞粘附识别（CAR）序列的化学修饰的环肽，其具有改进的性质，例如改善的稳定性。 还提供了制造和使用它们的方法。
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5.发明申请METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS 审中-公开用于联合5-FU和5-FU PRODRUGS的DPD抑制剂的施用方法公开(公告)号：US20080255168A1
公开(公告)日：2008-10-16
申请号：US12027064
申请日：2008-02-06
申请人： William Paul Peters , Mukur Gupta
发明人： William Paul Peters , Mukur Gupta
IPC分类号： A61K31/505 , A61P17/00
CPC分类号： A61K31/505 , A61K45/06 , A61K2300/00
摘要： Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient. Also provided are topical formulations comprising DPD, TP and/or UP inhibitors and methods of using same.
摘要翻译： 提供了用于改进DPD抑制剂与5-FU和/或5-FU前药组合的给药和给药方法，包括首先向有需要的患者施用基本上消除酶活性的DPD抑制剂，然后施用5-FU 或5-FU前药，其中5-FU或5-FU前药的水平在患者体内基本上超过DPD抑制剂。 还提供了包含DPD，TP和/或UP抑制剂的局部制剂及其使用方法。
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6.发明申请COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME 审中-公开包含局部DPD抑制剂的组合物及其在手足口综合征治疗中的使用方法公开(公告)号：US20090196833A1
公开(公告)日：2009-08-06
申请号：US12367367
申请日：2009-02-06
申请人： William Paul Peters , Mukur Gupta
发明人： William Paul Peters , Mukur Gupta
IPC分类号： A61K9/12 , A61K31/513
CPC分类号： A61K31/505 , A61K9/0014 , A61K9/06 , A61K31/513
摘要： Topical formulations comprising inhibitors of dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and/or uridine phosphorylase (UP) enzyme inhibitors are provided for the treatment of hand-foot syndrome (HFS) in cancer patients undergoing treatment with 5-FU and 5-FU prodrugs.
摘要翻译： 提供包含二氢嘧啶脱氢酶（DPD）抑制剂，胸苷磷酸化酶（TP）和/或尿苷磷酸化酶（UP））酶抑制剂的局部制剂用于治疗接受5-FU和5治疗的癌症患者的手足综合征（HFS） -FU前药。
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