摘要:
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
摘要:
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
摘要:
Chemically modified cyclic peptides comprising cell adhesion recognition (CAR) sequences are provided having improved properties, such as improved stability. Also provided are methods of making and using same.
摘要:
Improved methods for treating cancer which employ combinations comprising cadherin antagonists with certain anticancer agents or treatments are provided. The methods of the invention involve the administration of cadherin antagonist before, concurrent with, or after, administration of an anticancer agent or treatment and provide unexpectedly improved therapeutic benefit in the treatment of tumors growing in vivo.
摘要:
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
摘要:
A trolley capable mining truck includes a pantograph supported on machine frame for electrically connecting the truck with an overhead trolley line. A power system includes an onboard electrical power source providing electrical power to a pair of electric drive propulsion motors along a first electrical path in a first configuration of the power system. The electric drive propulsion motors, in turn, power ground engaging propulsion elements. In a second configuration of the power system, the pantograph provides electrical power from the overhead trolley line to the electric drive propulsion motors along a second electrical path, which includes a transient damping reactor. In a third configuration of the power system, the onboard electrical power source provides electrical power to an auxiliary device along a third electrical path including an auxiliary power converter, wherein the auxiliary power converter includes the transient damping reactor.
摘要:
Embodiments are described for an output driver circuit capable of maintaining a substantially constant output impedance across a wide range of output voltages. The driver circuit includes a pull-up circuit and a pull-down circuit, each having two or more current paths that either source currents to or sink currents from the output node. The addition of the third current path provides additional current such that the sum of the total currents have a magnitude that changes linearly as the output voltage at the output node is being driven.
摘要:
Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target-tissue specific transcriptional regulatory sequence (TRS) linked and controlling the expression of a heterologous enzyme, for example Varicella Zoster Virus Thymidine Kinase (VZV TK) or non-mammaliam Cytosine Deaminase (CD). A molecular chimaera is packaged into a synthetic retroviral particle that is capable of infecting mammalian tissue. This, in turn, may be administered to a host, and the TRS will be selectively transcriptionally activated in the target tissue (for example cancerous cells). Administration of compounds that are selectively metabolised by the enzyme produce cytotoxic or cytostatic metabolites in situ thereby selectively killing or arresting the growth of the target cells.
摘要:
The transcriptional regulatory sequence (TRS) of Carcinoembryonic Antigen (CEA) and molecular chimeras comprising the CEA TRS and DNA encoding a heterologous enzyme are described. Such molecular chimeras are capable of targeting the expression of the heterologous enzyme to CEA-positive cells. The heterologous enzyme may be cytosine deaminase.
摘要:
Methods and apparatuses for shifting data signals are disclosed herein. An apparatus may comprise a clock generation circuit, a delay path, and a driver. The clock generation circuit may be configured to receive an input clock signal and generate a plurality of clock signals based, at least in part, on the clock signal. A delay path may be coupled to the clock generation circuit and configured to receive the input clock signal and the plurality of clock signals. The delay path may be further configured to receive a data signal and delay the data signal based, at least in part, on the input clock signal and each of the plurality of clock signals. A driver may be coupled to the delay path and configured to receive the delayed data signal, and may further be configured to provide the delayed data signal to a bus.