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公开(公告)号：US20120258983A1
公开(公告)日：2012-10-11
申请号：US13418927
申请日：2012-03-13
申请人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
发明人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
CPC分类号： A61K31/47 , A61K9/146 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/282 , A61K9/2866 , A61K47/38
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译： 本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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公开(公告)号：US20120220625A1
公开(公告)日：2012-08-30
申请号：US13370540
申请日：2012-02-10
申请人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
发明人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
CPC分类号： A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译： 本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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公开(公告)号：US20100256184A1
公开(公告)日：2010-10-07
申请号：US12708359
申请日：2010-02-18
申请人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
发明人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
CPC分类号： A61K31/47 , A61K9/146 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/282 , A61K9/2866 , A61K47/38
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译： 本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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公开(公告)号：US20100074949A1
公开(公告)日：2010-03-25
申请号：US12583066
申请日：2009-08-13
申请人： William Rowe , Patricia Hurter , Christopher Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi
发明人： William Rowe , Patricia Hurter , Christopher Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi
CPC分类号： A61K31/47 , A61K9/0053 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/28 , A61K9/282 , A61K9/284 , A61K31/44 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译： 本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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![Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof](/abs-image/US/2013/10/08/US08552034B2/abs.jpg.150x150.jpg)
5.发明授权Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof 有权3-（6-（1-（2,2-二氟苯并[d] [1,3]二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基）苯甲酸的药物组合物，公开(公告)号：US08552034B2
公开(公告)日：2013-10-08
申请号：US13081750
申请日：2011-04-07
申请人： Marinus Jacobus Verwijs , Rossitza Gueorguieva Alargova , Ritu Rohit Kaushik , Irina Nikolaevna Kadiyala , Christopher Young
发明人： Marinus Jacobus Verwijs , Rossitza Gueorguieva Alargova , Ritu Rohit Kaushik , Irina Nikolaevna Kadiyala , Christopher Young
IPC分类号： A61K31/443 , C07D405/12
CPC分类号： A61K31/443 , A61K9/0053 , A61K9/1682 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K31/47
摘要： A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.
摘要翻译： 包含化合物1（3-（6-（1-（2,2-二氟苯并[d] [1,3]二氧杂环戊烯-5-基）环丙烷甲酰胺基）-3-甲基吡啶-2-基）苯甲酸的药物组合物） 和至少一种选自：填料，稀释剂，崩解剂，表面活性剂，粘合剂，助流剂和润滑剂的赋形剂，所述组合物适合于有需要的患者口服给药以治疗CFTR介导的疾病，例如 作为囊性纤维化。 用于治疗有需要的患者的方法包括向患者施用化合物1的口服药物制剂。
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![PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID AND ADMINISTRATION THEREOF](/abs-image/US/2011/10/20/US20110256220A1/abs.jpg.150x150.jpg)
6.发明申请PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID AND ADMINISTRATION THEREOF 有权3-（6-（1-（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-基）环丙烷氧羰基）-3-甲基吡啶-2-基）苯甲酸及其施用的药物组合物公开(公告)号：US20110256220A1
公开(公告)日：2011-10-20
申请号：US13081750
申请日：2011-04-07
申请人： Marinus Jacobus Verwijs , Rossitza Gueorguieva Alargova , Ritu Rohit Kaushik , Irina Nikolaevna Kadiyala , Christopher Young
发明人： Marinus Jacobus Verwijs , Rossitza Gueorguieva Alargova , Ritu Rohit Kaushik , Irina Nikolaevna Kadiyala , Christopher Young
IPC分类号： A61K9/28 , A61K47/02 , A61K47/32 , A61K31/443 , A61P25/28 , A61P1/10 , A61P11/06 , A61P1/16 , A61P9/00 , A61K47/38 , A61P3/10
CPC分类号： A61K31/443 , A61K9/0053 , A61K9/1682 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K31/47
摘要： A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.
摘要翻译： 包含化合物1（3-（6-（1-（2,2-二氟苯并[d] [1,3]二氧杂环戊烯-5-基）环丙烷甲酰胺基）-3-甲基吡啶-2-基）苯甲酸的药物组合物） 和至少一种选自：填料，稀释剂，崩解剂，表面活性剂，粘合剂，助流剂和润滑剂的赋形剂，所述组合物适合于有需要的患者口服给药以治疗CFTR介导的疾病，例如 作为囊性纤维化。 用于治疗有需要的患者的方法包括向患者施用化合物1的口服药物制剂。
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