Patent search ap:"Fredrick F. Van Goor" Page 1

1.

发明授权
Modulators of ATP-Binding Cassette transporters 有权
Title translation: ATP结合盒转运蛋白的调节剂

公开(公告)号：US08802700B2

公开(公告)日：2014-08-12

申请号：US13492164

申请日：2012-06-08

Applicant: Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield

Inventor： Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield

IPC: A61K31/04 , A61K31/4725 , A61K31/4709

CPC classification number: A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

2.

发明授权
Modulators of ATP-binding cassette transporters 有权
Title translation: ATP结合盒转运蛋白的调节剂

公开(公告)号：US08623905B2

公开(公告)日：2014-01-07

申请号：US12767472

申请日：2010-04-26

Applicant: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa

Inventor： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa

IPC: A61K31/404 , C07D209/40

CPC classification number: A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFFR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFFR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

3.

发明申请
Pharmaceutical Composition and Administrations Thereof 审中-公开
Title translation: 药物组成及其主管部门

公开(公告)号：US20120258983A1

公开(公告)日：2012-10-11

申请号：US13418927

申请日：2012-03-13

Applicant: William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor

Inventor： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor

IPC: A61K31/47 , A61P37/00 , A61P11/00 , A61P19/10 , A61P19/08

CPC classification number: A61K31/47 , A61K9/146 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/282 , A61K9/2866 , A61K47/38

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

Abstract translation: 本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。

4.

发明申请
Pharmaceutical Compositions and Administrations Thereof 审中-公开
Title translation: 药物组合物及其主管部门

公开(公告)号：US20110288122A1

公开(公告)日：2011-11-24

申请号：US13112982

申请日：2011-05-20

Applicant: Fredrick F. Van Goor , William Lawrence Burton , Chien-Jung Huang , Paul Adrian Negulescu , Haihui Yu

Inventor： Fredrick F. Van Goor , William Lawrence Burton , Chien-Jung Huang , Paul Adrian Negulescu , Haihui Yu

IPC: A61K31/47 , A61P11/06 , A61P11/08 , A61P11/02 , A61P1/00 , A61P1/18 , A61P1/16 , A61P7/00 , A61P7/02 , A61P3/00 , A61P43/00 , A61P3/10 , A61P35/00 , A61P19/08 , A61P25/28 , A61P1/02 , A61P25/16 , A61P25/00 , A61P21/00 , A61P27/02 , A61P19/10 , A61P25/08 , A61P11/00

CPC classification number: C07D215/233 , A61K31/47

Abstract: The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, solids forms, and pharmaceutical compositions thereof for the treatment of CFTR mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations.

Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，固体形式及其药物组合物的用途用于治疗CFTR介导的疾病，特别是囊性纤维化，具有特异性遗传突变的患者。

5.

发明申请
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES 审中-公开
Title translation: 用于治疗CYSTIC FIBROSIS和其他慢性疾病的组合物

公开(公告)号：US20110098311A1

公开(公告)日：2011-04-28

申请号：US12910727

申请日：2010-10-22

Applicant: Fredrick F. Van Goor , William Lawrence Burton

Inventor： Fredrick F. Van Goor , William Lawrence Burton

IPC: A61K31/497 , A61K31/4965 , A61P11/00 , A61P1/00 , A61P15/08 , A61P9/00 , A61P3/00 , A61P25/00 , A61P19/00 , A61P25/16 , A61P25/28

CPC classification number: A61K31/5377 , A61K31/357 , A61K31/4025 , A61K31/404 , A61K31/443 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/4965 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Abstract translation: 本发明涉及包含上述钠通道活性抑制剂的药物组合物与至少一种式A，式B，式C或式D的ABC转运蛋白调节剂化合物的组合。本发明还涉及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是使用药物组合组合物的囊性纤维化的方法。

6.

发明申请
PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权
Title translation: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR制造调制器的工艺

公开(公告)号：US20100267768A1

公开(公告)日：2010-10-21

申请号：US12728173

申请日：2010-03-19

Applicant: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik

Inventor： John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik

IPC: A61K31/47 , C07D215/233 , C07C69/96 , C07D307/77 , A61P11/06 , A61P1/18 , A61P15/10 , A61P37/08 , A61P1/16 , A61P3/00 , A61P25/28 , A61P3/10 , A61P37/00 , A61P7/12 , C12N5/07 , C12Q1/02

CPC classification number: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55

Abstract: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

Abstract translation: 本发明提供了制备式1化合物的方法，包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。

7.

发明申请
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权
Title translation: ATP结合蛋白转运蛋白的调节剂

公开(公告)号：US20120309758A1

公开(公告)日：2012-12-06

申请号：US13492164

申请日：2012-06-08

Applicant: Urvi Sheth , Lev T.D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield

Inventor： Urvi Sheth , Lev T.D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield

IPC: A61K31/47 , A61K31/4709 , C12N5/071 , C07D215/56 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P25/00 , A61P3/00 , A61P11/00 , A61P1/18 , A61P19/10 , A61P3/10 , A61P27/02 , A61P11/06 , A61P15/08 , C07D401/12

CPC classification number: A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

8.

发明申请
PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF 审中-公开
Title translation: 药物组合物及其药理学

公开(公告)号：US20120220625A1

公开(公告)日：2012-08-30

申请号：US13370540

申请日：2012-02-10

Applicant: William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor

Inventor： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor

IPC: A61K31/47 , A61P19/08 , A61P11/00 , A61P19/10

CPC classification number: A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

Abstract translation: 本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。