公开(公告)号：US08415307B1

公开(公告)日：2013-04-09

申请号：US13167495

申请日：2011-06-23

申请人： William V. Curran ,  Christopher M. Liu ,  Amy C. D. Bombardier ,  Richard A. Leese ,  You Seok Hwang ,  Blaise S. Lippa ,  Yanzhi Zhang

发明人： William V. Curran ,  Christopher M. Liu ,  Amy C. D. Bombardier ,  Richard A. Leese ,  You Seok Hwang ,  Blaise S. Lippa ,  Yanzhi Zhang

IPC分类号： A61K38/08

CPC分类号： C07K7/62 ,  A01N43/713 ,  A61K38/12 ,  Y02A50/473 ,  Y10S930/19

摘要： Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

摘要翻译： 本文提供了可衍生自多粘菌素（例如多粘菌素A）的新型化合物和新的受保护化合物。该新化合物对多种革兰氏阴性细菌具有抗菌性能，与多粘菌素如多粘菌素A相比具有降低的毒性。还提供 是含有新化合物和新型受保护化合物的抗菌药物组合物，以及制备抗菌化合物和受保护化合物的方法。