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公开(公告)号：US08415307B1
公开(公告)日：2013-04-09
申请号：US13167495
申请日：2011-06-23
申请人： William V. Curran , Christopher M. Liu , Amy C. D. Bombardier , Richard A. Leese , You Seok Hwang , Blaise S. Lippa , Yanzhi Zhang
发明人： William V. Curran , Christopher M. Liu , Amy C. D. Bombardier , Richard A. Leese , You Seok Hwang , Blaise S. Lippa , Yanzhi Zhang
IPC分类号： A61K38/08
CPC分类号： C07K7/62 , A01N43/713 , A61K38/12 , Y02A50/473 , Y10S930/19
摘要： Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.
摘要翻译： 本文提供了可衍生自多粘菌素（例如多粘菌素A）的新型化合物和新的受保护化合物。该新化合物对多种革兰氏阴性细菌具有抗菌性能，与多粘菌素如多粘菌素A相比具有降低的毒性。还提供 是含有新化合物和新型受保护化合物的抗菌药物组合物，以及制备抗菌化合物和受保护化合物的方法。
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公开(公告)号：US20080051326A1
公开(公告)日：2008-02-28
申请号：US11667645
申请日：2005-11-11
申请人： Dylan Alexander , Richard Baltz , Paul Brian , Marie-Francoise Coeffet-Le Gal , Sascha Doekel , Xiaowei He , Vidya Kulkarni , Christopher Leitheiser , Vivian Pak Woon Miao , Kien Trung Nguyen , Ian Barrie Parr , Daniel Ritz , Yanzhi Zhang
发明人： Dylan Alexander , Richard Baltz , Paul Brian , Marie-Francoise Coeffet-Le Gal , Sascha Doekel , Xiaowei He , Vidya Kulkarni , Christopher Leitheiser , Vivian Pak Woon Miao , Kien Trung Nguyen , Ian Barrie Parr , Daniel Ritz , Yanzhi Zhang
摘要： The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新颖的三肽类化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型去肽肽化合物的方法和用于制备这些化合物的中间体。
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3.发明申请APPARATUS AND METHOD FOR INTERNETWORKING INTERFACE IN MULTIMODE WIRELESS COMMUNICATION 有权多模式无线通信中互联接口的设备和方法公开(公告)号：US20120069823A1
公开(公告)日：2012-03-22
申请号：US13197179
申请日：2011-08-03
申请人： Su-Lin Low , Wei-Dong Zhang , Hausting Hong , Yanzhi Zhang , Jianzhi Wang
发明人： Su-Lin Low , Wei-Dong Zhang , Hausting Hong , Yanzhi Zhang , Jianzhi Wang
IPC分类号： H04W92/00
摘要： An apparatus supporting MTC in an LTE environment including an LTE modem and a CDMA modem. The LTE modem accesses a first wireless network and executes first data transactions, where the first wireless network comports with LTE standards. The CDMA modem is operationally coupled to the LTE modem, and accesses a second wireless network and executes second data transactions, where the second wireless network comports with one or more CDMA-based standards. The CDMA modem includes an inter-radio access technology (IRAT) API element and an inter-process communication (IPC) module. The IRAT API element is configured to send/receive IRAT messages via function calls to/from the LTE modem, where the IRAT messages remain the same regardless of interface requirements for the LTE modem. The IPC module is coupled to the IRAT API element, and is configured to generalize the function calls to enable the CDMA modem to interoperate with the LTE modem.
摘要翻译： 一种在LTE环境中支持MTC的装置，包括LTE调制解调器和CDMA调制解调器。 LTE调制解调器访问第一无线网络并执行第一数据事务，其中第一无线网络与LTE标准相匹配。 CDMA调制解调器可操作地耦合到LTE调制解调器，并且访问第二无线网络并执行第二数据事务，其中第二无线网络与一个或多个基于CDMA的标准相匹配。 CDMA调制解调器包括无线电接入技术（IRAT）API元件和进程间通信（IPC）模块。 IRAT API元素配置为通过向/从LTE调制解调器的功能呼叫发送/接收IRAT消息，其中IRAT消息保持不变，无论LTE调制解调器的接口要求如何。 IPC模块耦合到IRAT API元件，并被配置为推广功能调用以使CDMA调制解调器与LTE调制解调器互操作。
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4.发明授权Lipopeptide stereoisomers, methods for preparing same and useful intermediates 失效脂肽立体异构体，其制备方法和有用的中间体公开(公告)号：US07335726B2
公开(公告)日：2008-02-26
申请号：US11448066
申请日：2006-06-06
申请人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
发明人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
IPC分类号： C07K7/60
摘要： The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
摘要翻译： 本发明提供达托霉素立体异构体化合物，制备达托霉素和达托霉素立体异构体化合物的方法和中间体，以及这些化合物的药物组合物和使用这些组合物作为抗菌剂的方法。
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5.发明授权公开(公告)号：US09125120B2
公开(公告)日：2015-09-01
申请号：US13197179
申请日：2011-08-03
申请人： Su-Lin Low , Wei-Dong Zhang , Hausting Hong , Yanzhi Zhang , Jianzhi Wang
发明人： Su-Lin Low , Wei-Dong Zhang , Hausting Hong , Yanzhi Zhang , Jianzhi Wang
摘要： An apparatus supporting MTC in an LTE environment including an LTE modem and a CDMA modem. The LTE modem accesses a first wireless network and executes first data transactions, where the first wireless network comports with LTE standards. The CDMA modem is operationally coupled to the LTE modem, and accesses a second wireless network and executes second data transactions, where the second wireless network comports with one or more CDMA-based standards. The CDMA modem includes an inter-radio access technology (IRAT) API element and an inter-process communication (IPC) module. The IRAT API element is configured to send/receive IRAT messages via function calls to/from the LTE modem, where the IRAT messages remain the same regardless of interface requirements for the LTE modem. The IPC module is coupled to the IRAT API element, and is configured to generalize the function calls to enable the CDMA modem to interoperate with the LTE modem.
摘要翻译： 一种在LTE环境中支持MTC的装置，包括LTE调制解调器和CDMA调制解调器。 LTE调制解调器访问第一无线网络并执行第一数据事务，其中第一无线网络与LTE标准相匹配。 CDMA调制解调器可操作地耦合到LTE调制解调器，并且访问第二无线网络并执行第二数据事务，其中第二无线网络与一个或多个基于CDMA的标准相匹配。 CDMA调制解调器包括无线电接入技术（IRAT）API元件和进程间通信（IPC）模块。 IRAT API元素配置为通过向/从LTE调制解调器的功能呼叫发送/接收IRAT消息，其中IRAT消息保持不变，无论LTE调制解调器的接口要求如何。 IPC模块耦合到IRAT API元件，并被配置为推广功能调用以使CDMA调制解调器与LTE调制解调器互操作。
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6.发明授权Lipopeptide stereoisomers, methods for preparing same, and useful intermediates 失效脂肽立体异构体，其制备方法和有用的中间体公开(公告)号：US07262268B2
公开(公告)日：2007-08-28
申请号：US10213218
申请日：2002-08-06
申请人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
发明人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
IPC分类号： A61K38/12
摘要： The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
摘要翻译： 本发明提供达托霉素立体异构体化合物，制备达托霉素和达托霉素立体异构体化合物的方法和中间体，以及这些化合物的药物组合物和使用这些组合物作为抗菌剂的方法。
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7.发明申请Lipopeptide stereoisomers, methods for preparing same and useful intermediates 失效脂肽立体异构体，其制备方法和有用的中间体公开(公告)号：US20060223983A1
公开(公告)日：2006-10-05
申请号：US11448066
申请日：2006-06-06
申请人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
发明人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
IPC分类号： C07K7/60
摘要： The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
摘要翻译： 本发明提供达托霉素立体异构体化合物，制备达托霉素和达托霉素立体异构体化合物的方法和中间体，以及这些化合物的药物组合物和使用这些组合物作为抗菌剂的方法。
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