公开(公告)号：US20050124892A1

公开(公告)日：2005-06-09

申请号：US10731302

申请日：2003-12-09

申请人： William Weitzel ,  Kang Kim ,  Matthew O'Donnell ,  Jonathan Rubin ,  Hua Xie ,  Xunchang Chen

发明人： William Weitzel ,  Kang Kim ,  Matthew O'Donnell ,  Jonathan Rubin ,  Hua Xie ,  Xunchang Chen

IPC分类号： A61B8/08 ,  A61B8/06

CPC分类号： A61B8/485 ,  A61B8/08

摘要： Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.

摘要翻译： 提供了用于测量血管壁的机械性能的方法和系统以及用于确定血管结构健康的方法和系统，其中测量由具有改变的透壁力的生理压力引起的血管壁的局部变形。 进行非侵入性自由手超声扫描程序以施加外力，与测量受试者血压时产生的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 当施加的压力与内部基线舒张压相匹配时，应变和应变率在心脏周期上增加10倍。 使用相敏二维斑点跟踪算法，在整个变形过程的血管壁中评估径向动脉应变。 开发弹性模量重建程序来估计血管壁的非线性弹性性质。

公开(公告)号：US20080081994A1

公开(公告)日：2008-04-03

申请号：US11866000

申请日：2007-10-02

申请人： KANG KIM ,  William Weitzel ,  Jonathan Rubin ,  Congxian Jia ,  Matthew O'Donnell ,  Theodore Kolias

发明人： KANG KIM ,  William Weitzel ,  Jonathan Rubin ,  Congxian Jia ,  Matthew O'Donnell ,  Theodore Kolias

IPC分类号： A61B8/00

CPC分类号： A61B5/0285 ,  A61B8/06 ,  A61B8/08 ,  A61B8/485 ,  G01S7/52036 ,  G01S7/52042

摘要： An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

摘要翻译： 优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量中估计血管壁的非线性弹性特性。 使用非侵入性自由手超声扫描程序来施加外力，与测量受试者血压的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。 重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。