-
公开(公告)号：US4803210A
公开(公告)日：1989-02-07
申请号：US183537
申请日：1988-04-14
IPC分类号： C07D498/04 , A61K31/42
CPC分类号： C07D498/04
摘要： Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
摘要翻译： 三环恶唑酮增强心肌收缩力，可用作心力衰竭治疗心力衰竭。
-
公开(公告)号：US4743607A
公开(公告)日：1988-05-10
申请号：US55666
申请日：1987-05-29
IPC分类号： A61K31/435 , A61P9/00 , A61P9/04 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： Tricyclic imidazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. The compounds have the formula: ##STR1##
-
公开(公告)号：US5428045A
公开(公告)日：1995-06-27
申请号：US111814
申请日：1993-08-25
IPC分类号： C07D213/85 , A61K31/44 , C07D213/55 , C07D213/56 , C07D213/57
CPC分类号： C07D213/85
摘要： Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
摘要翻译： 新型5-酰基-2-（1H）吡啶酮及其作为强心剂的用途。 典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈 惰性有机溶剂。
-
公开(公告)号：US5212315A
公开(公告)日：1993-05-18
申请号：US703936
申请日：1991-07-29
IPC分类号： C07D213/42 , C07D213/64 , C07D213/73 , C07D213/80 , C07D213/82 , C07D213/85
CPC分类号： C07D213/42 , C07D213/64 , C07D213/73 , C07D213/80 , C07D213/82 , C07D213/85
摘要： This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
摘要翻译： 本发明涉及5-酰基-2（1H） - 吡啶酮的烷氧基亚氨基醚衍生物及其用作治疗心力衰竭的强心剂，以及其制备方法。
-
5.发明授权
公开(公告)号：US5118696A
公开(公告)日：1992-06-02
申请号：US612157
申请日：1990-11-09
IPC分类号： C07D213/85
CPC分类号： C07D213/85
摘要： Novel 5-acyl-2-(1H)pyrdinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
摘要翻译： 新型5-酰基-2-（1H）哒嗪酮及其作为强心剂的用途。 典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈 惰性有机溶剂。
-
6.发明授权
公开(公告)号：US4990519A
公开(公告)日：1991-02-05
申请号：US484581
申请日：1990-02-23
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
摘要翻译： 本发明涉及可用作治疗高血压和哮喘的蛋白激酶C抑制剂的新型喹喔啉-2-酮。 本发明还包括一种制备涉及溴 - 喹啉化合物与丁基锂反应的中间体酮化合物的新方法，并进一步使锂化化合物与N-甲基-N-甲氧基烷酰胺反应。
-
公开(公告)号：US4999431A
公开(公告)日：1991-03-12
申请号：US483831
申请日：1990-02-23
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
摘要翻译： 本发明涉及可用作治疗高血压和哮喘的蛋白激酶C抑制剂的新型喹喔啉-2-酮。 本发明还包括一种制备涉及溴 - 喹啉化合物与丁基锂反应的中间体酮化合物的新方法，并进一步使锂化化合物与N-甲基-N-甲氧基烷酰胺反应。
-
公开(公告)号：US4886811A
公开(公告)日：1989-12-12
申请号：US261435
申请日：1988-10-24
IPC分类号： A61K31/47 , A61P9/08 , A61P9/12 , A61P11/08 , A61P43/00 , C07D215/14 , C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
-
公开(公告)号：US4568751A
公开(公告)日：1986-02-04
申请号：US490081
申请日：1983-04-29
IPC分类号： C07D213/64 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/455 , A61P9/04 , A61P9/06 , C07C67/00 , C07C213/00 , C07C225/14 , C07C225/16 , C07D213/60 , C07D213/85 , C07D213/73 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D213/85
摘要： Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
摘要翻译： 新型5-酰基-2-（1H）吡啶酮及其作为强心剂的用途。 典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈 惰性有机溶剂。
-
10.发明授权Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties 失效具有强心性质的某些3-羧酸酯或3-氨基甲酰基-5-酰基-2-（1H） - 吡啶酮
公开(公告)号：US4853395A
公开(公告)日：1989-08-01
申请号：US121543
申请日：1987-11-17
IPC分类号： C07D213/85
CPC分类号： C07D213/85
摘要： Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
摘要翻译： 新型5-酰基-2-（1H）吡啶酮及其作为强心剂的用途。 典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈 惰性有机溶剂。
-
-
-
-
-
-
-
-
-
搜索结果
52 条记录 (耗时 0.023 秒)
