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1.发明授权
公开(公告)号：US4990519A
公开(公告)日：1991-02-05
申请号：US484581
申请日：1990-02-23
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
摘要翻译： 本发明涉及可用作治疗高血压和哮喘的蛋白激酶C抑制剂的新型喹喔啉-2-酮。 本发明还包括一种制备涉及溴 - 喹啉化合物与丁基锂反应的中间体酮化合物的新方法，并进一步使锂化化合物与N-甲基-N-甲氧基烷酰胺反应。
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公开(公告)号：US4999431A
公开(公告)日：1991-03-12
申请号：US483831
申请日：1990-02-23
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
摘要翻译： 本发明涉及可用作治疗高血压和哮喘的蛋白激酶C抑制剂的新型喹喔啉-2-酮。 本发明还包括一种制备涉及溴 - 喹啉化合物与丁基锂反应的中间体酮化合物的新方法，并进一步使锂化化合物与N-甲基-N-甲氧基烷酰胺反应。
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公开(公告)号：US4886811A
公开(公告)日：1989-12-12
申请号：US261435
申请日：1988-10-24
IPC分类号： A61K31/47 , A61P9/08 , A61P9/12 , A61P11/08 , A61P43/00 , C07D215/14 , C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
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公开(公告)号：US08809386B2
公开(公告)日：2014-08-19
申请号：US13321415
申请日：2010-05-21
申请人： Phillip J. Robinson , Sanja Sever
发明人： Phillip J. Robinson , Sanja Sever
IPC分类号： A61K31/35
CPC分类号： A61K31/275 , A61K31/352 , A61K31/404
摘要： There is provided a method for promoting dynamin ring formation and/or maintenance of dynamin rings in a cell, comprising treating the cell with an effective amount of a dynamin ring stabilizer, or a prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. The maintenance or accumulation of dynamin ring formation has particular application in the prophylaxis or treatment of a kidney disease or condition characterized by proteinuria. A dynamin ring stabilizer can be any agent that interacts with dynamin to promote dynamin ring assembly and/or inhibit dynamin ring disassembly. There are also provided methods for prophylaxis or treatment of podocyte dysfunction and/or maintaining or inducing actin cytoskeleton formation in a cell utilizing dynamin ring stabilizers, and for screening a test agent for use as a dynamin ring stabilizer.
摘要翻译： 提供了促进细胞中dynamin环形成和/或维持Dynamin环的方法，包括用有效量的dynamin环稳定剂或dynamin环稳定剂的前药或药学上可接受的盐处理细胞。 dynamin环形成的维持或积累特别适用于预防或治疗肾脏疾病或蛋白尿特征的病症。 Dynamin环稳定剂可以是与dynamin相互作用以促进dynamin环组装和/或抑制dynamin环分解的任何试剂。 还提供了用于预防或治疗足细胞功能障碍和/或维持或诱导使用Dynamin环稳定剂的细胞中的肌动蛋白细胞骨架形成并用于筛选用作Dynamin环稳定剂的测试剂的方法。
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公开(公告)号：US20120122968A1
公开(公告)日：2012-05-17
申请号：US13321415
申请日：2010-05-21
申请人： Phillip J. Robinson , Sanja Sever
发明人： Phillip J. Robinson , Sanja Sever
IPC分类号： A61K31/277 , A61P13/12 , A61K31/352 , A61K31/166 , C12N5/071 , C12Q1/34
CPC分类号： A61K31/275 , A61K31/352 , A61K31/404
摘要： There is provided a method for promoting dynamin ring formation and/or maintenance of dynamin rings in a cell, comprising treating the cell with an effective amount of a dynamin ring stabilizer, or a prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. The maintenance or accumulation of dynamin ring formation has particular application in the prophylaxis or treatment of a kidney disease or condition characterized by proteinuria. A dynamin ring stabilizer can be any agent that interacts with dynamin to promote dynamin ring assembly and/or inhibit dynamin ring disassembly. There are also provided methods for prophylaxis or treatment of podocyte dysfunction and/or maintaining or inducing actin cytoskeleton formation in a cell utilizing dynamin ring stabilizers, and for screening a test agent for use as a dynamin ring stabilizer.
摘要翻译： 提供了促进细胞中dynamin环形成和/或维持Dynamin环的方法，包括用有效量的dynamin环稳定剂或dynamin环稳定剂的前药或药学上可接受的盐处理细胞。 dynamin环形成的维持或积累特别适用于预防或治疗肾脏疾病或蛋白尿特征的病症。 Dynamin环稳定剂可以是与dynamin相互作用以促进dynamin环组装和/或抑制dynamin环分解的任何试剂。 还提供了用于预防或治疗足细胞功能障碍和/或维持或诱导使用Dynamin环稳定剂的细胞中的肌动蛋白细胞骨架形成并用于筛选用作Dynamin环稳定剂的测试剂的方法。
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