专利检索 ap:("Wisconsin Alumni Research Foundation") AND inv:"Angela Williams" 第 1 页

1.

发明授权
Penetration of cerebral spinal fluid into the brain parenchyma using temporally patterned neuromodulation 有权

公开(公告)号：US12076554B2

公开(公告)日：2024-09-03

申请号：US17854078

申请日：2022-06-30

申请人： Wisconsin Alumni Research Foundation

发明人： Kip Ludwig , Justin Williams , Angela Williams , Samuel Poore

IPC分类号： A61N1/05 , A61N1/04 , A61N1/36

CPC分类号： A61N1/0548 , A61N1/0432 , A61N1/36025

摘要： Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (TBL) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.