公开(公告)号：US11028113B2

公开(公告)日：2021-06-08

申请号：US16664722

申请日：2019-10-25

Applicant: Wisconsin Alumni Research Foundation

Inventor： Timothy S. Bugni ,  Monica Tallarico Pupo ,  David R. Andes ,  Cameron R. Currie ,  Humberto Enrique Ortega Dominguez

IPC: A61K31/7048 ,  A61K31/351 ,  A61K31/4196 ,  A61K31/4015 ,  A61K31/513 ,  C07H17/04 ,  C12N1/20

Abstract: Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cyphomycin, such as pharmaceutical compositions including effective amounts of Cyphomycin for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Cyphomycin and compositions thereof are disclosed.