公开(公告)号：US20220117904A1

公开(公告)日：2022-04-21

申请号：US17506614

申请日：2021-10-20

申请人： Wisconsin Alumni Research Foundation

发明人： Shaoqin Gong ,  Mingzhou Ye ,  David R. Andes

IPC分类号： A61K9/51 ,  A61K9/50 ,  C08G63/688 ,  A61P31/04 ,  A61K31/496

摘要： Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.

公开(公告)号：US11028113B2

公开(公告)日：2021-06-08

申请号：US16664722

申请日：2019-10-25

申请人： Wisconsin Alumni Research Foundation

发明人： Timothy S. Bugni ,  Monica Tallarico Pupo ,  David R. Andes ,  Cameron R. Currie ,  Humberto Enrique Ortega Dominguez

IPC分类号： A61K31/7048 ,  A61K31/351 ,  A61K31/4196 ,  A61K31/4015 ,  A61K31/513 ,  C07H17/04 ,  C12N1/20

摘要： Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cyphomycin, such as pharmaceutical compositions including effective amounts of Cyphomycin for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Cyphomycin and compositions thereof are disclosed.