公开(公告)号：US20240345082A1

公开(公告)日：2024-10-17

申请号：US18587898

申请日：2024-02-26

Applicant: Wisconsin Alumni Research Foundation

Inventor： David Gamm ,  Praveen Joseph Susai Manickam ,  Michael Phillips ,  Elizabeth Capowski

IPC: G01N33/569 ,  C12N5/0793

CPC classification number: G01N33/56966 ,  C12N5/062

Abstract: The present disclosure provides methods for obtaining enriched populations of human red/green cone photoreceptor precursor cells with at least one of ALCAM/CD166-positive ITGA6/CD49f-negative, TNFRSF10B/CD262-negative, or NGFR/CD271-negative cell surface markers, compositions of enriched populations of human red/green cone photoreceptor precursor cells, methods for using said compositions for testing and identifying therapeutic agents specific for retinal degenerative diseases, disorders, injuries, or toxicities, and therapeutic agents specific for retinal degenerative diseases, disorders, injuries, or toxicities identified by these methods.