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公开(公告)号：US11371003B2
公开(公告)日：2022-06-28
申请号：US15016753
申请日：2016-02-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Yei Hwan Jung , Michael Phillips , David Gamm , Shaoqin Gong
Abstract: Photoreceptor scaffolds and scaffold systems including the photoreceptor scaffolds are described herein. The scaffolds and scaffold systems can be used for transplantation of organized photoreceptor tissue, with or without RPE, which may improve grafted cell survival, integration, and functional visual rescue. Particularly, the photoreceptor scaffold is structured from a biocompatible film, patterned with an array of unique through-holes having a curvilinear cell receiver and at least one cell guide channel.
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公开(公告)号：US20240345082A1
公开(公告)日：2024-10-17
申请号：US18587898
申请日：2024-02-26
Applicant: Wisconsin Alumni Research Foundation
Inventor： David Gamm , Praveen Joseph Susai Manickam , Michael Phillips , Elizabeth Capowski
IPC: G01N33/569 , C12N5/0793
CPC classification number: G01N33/56966 , C12N5/062
Abstract: The present disclosure provides methods for obtaining enriched populations of human red/green cone photoreceptor precursor cells with at least one of ALCAM/CD166-positive ITGA6/CD49f-negative, TNFRSF10B/CD262-negative, or NGFR/CD271-negative cell surface markers, compositions of enriched populations of human red/green cone photoreceptor precursor cells, methods for using said compositions for testing and identifying therapeutic agents specific for retinal degenerative diseases, disorders, injuries, or toxicities, and therapeutic agents specific for retinal degenerative diseases, disorders, injuries, or toxicities identified by these methods.
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Patent Agency Ranking
公开(公告)号：US20240228931A9
公开(公告)日：2024-07-11
申请号：US17769549
申请日：2020-10-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Inkyu Lee , Juhwan Lee , Michael Phillips , David Gamm , Shaoqin Gong
IPC: C12M1/12 , C12N5/0793
CPC classification number: C12M25/14 , C12N5/062 , C12N2533/30
Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.
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公开(公告)号：US20170226459A1
公开(公告)日：2017-08-10
申请号：US15016753
申请日：2016-02-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Yei Hwan Jung , Michael Phillips , David Gamm , Shaoqin Gong
Abstract: Photoreceptor scaffolds and scaffold systems including the photoreceptor scaffolds are described herein. The scaffolds and scaffold systems can be used for transplantation of organized photoreceptor tissue, with or without RPE, which may improve grafted cell survival, integration, and functional visual rescue. Particularly, the photoreceptor scaffold is structured from a biocompatible film, patterned with an array of unique through-holes having a curvilinear cell receiver and at least one cell guide channel.
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公开(公告)号：US20240132823A1
公开(公告)日：2024-04-25
申请号：US17769549
申请日：2020-10-11
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Inkyu Lee , Juhwan Lee , Michael Phillips , David Gamm , Shaoqin Gong
IPC: C12M1/12 , C12N5/0793
CPC classification number: C12M25/14 , C12N5/062 , C12N2533/30
Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.
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公开(公告)号：US20230151327A1
公开(公告)日：2023-05-18
申请号：US17820488
申请日：2022-08-17
Applicant: Wisconsin Alumni Research Foundation
Inventor： David Gamm , Steven Mayerl
IPC: C12N5/079
CPC classification number: C12N5/0621 , C12N2503/02 , C12N2503/04 , C12N2513/00
Abstract: This disclosure relates to genetically engineered retinal organoids that can be used to test therapeutic treatments.
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公开(公告)号：US20200010799A1
公开(公告)日：2020-01-09
申请号：US16506471
申请日：2019-07-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Juhwan Lee , Yei Hwan Jung , Michael Phillips , David Gamm , Shaoqin Gong , Inkyu Lee
IPC: C12N5/0793
Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one cube-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one cube-shaped reservoir.
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