公开(公告)号：US20240261416A1

公开(公告)日：2024-08-08

申请号：US18426920

申请日：2024-01-30

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Haibo Xie ,  Yunxiang Wu ,  Junzhuo Liao ,  Chunrong Li ,  Ira Tandon ,  Hua Tang

IPC: A61K47/55 ,  C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

CPC classification number: A61K47/55 ,  C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

Abstract: Provided herein are achiral cereblon (CRBN) ligands based on phenyl dihydrouracil that have optimal binding to CRBN without having chiral carbons. Also provided herein are the proteolysis targeting chimeras (PROTACs) comprising the CRBN ligands and a protein binder, pharmaceutical compositions containing the PROTACs, and methods of treating diseases using the PROTACs.