公开(公告)号：US20240261416A1

公开(公告)日：2024-08-08

申请号：US18426920

申请日：2024-01-30

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Haibo Xie ,  Yunxiang Wu ,  Junzhuo Liao ,  Chunrong Li ,  Ira Tandon ,  Hua Tang

IPC: A61K47/55 ,  C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

CPC classification number: A61K47/55 ,  C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

Abstract: Provided herein are achiral cereblon (CRBN) ligands based on phenyl dihydrouracil that have optimal binding to CRBN without having chiral carbons. Also provided herein are the proteolysis targeting chimeras (PROTACs) comprising the CRBN ligands and a protein binder, pharmaceutical compositions containing the PROTACs, and methods of treating diseases using the PROTACs.

公开(公告)号：US11427569B2

公开(公告)日：2022-08-30

申请号：US16789887

申请日：2020-02-13

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Gabrielle N. Winston-McPherson ,  Haibo Xie ,  Alan D. Attie ,  Mark Patrick Keller ,  Ka Yang

IPC: C07D403/06 ,  C07D401/14 ,  C07D409/06 ,  C07D413/14

Abstract: Described are benzoimidazole indolyl methane compounds, pharmaceutical compositions containing them, and use of the compounds to inhibit PCSK9-mediated ailments. The compounds have the structure:

公开(公告)号：US20200262819A1

公开(公告)日：2020-08-20

申请号：US16789887

申请日：2020-02-13

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Gabrielle N. Winston McPherson ,  Haibo Xie ,  Alan D. Attie ,  Mark Patrick Keller ,  Ka Yang

IPC: C07D403/06 ,  C07D401/14 ,  C07D413/14 ,  C07D409/06

Abstract: Described are benzoimidazole indolyl methane compounds, pharmaceutical compositions containing them, and use of the compounds to inhibit PCSK9-mediated ailments. The compounds have the structure: