公开(公告)号：US11427569B2

公开(公告)日：2022-08-30

申请号：US16789887

申请日：2020-02-13

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Gabrielle N. Winston-McPherson ,  Haibo Xie ,  Alan D. Attie ,  Mark Patrick Keller ,  Ka Yang

IPC: C07D403/06 ,  C07D401/14 ,  C07D409/06 ,  C07D413/14

Abstract: Described are benzoimidazole indolyl methane compounds, pharmaceutical compositions containing them, and use of the compounds to inhibit PCSK9-mediated ailments. The compounds have the structure:

公开(公告)号：US20230310400A9

公开(公告)日：2023-10-05

申请号：US17359857

申请日：2021-06-28

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Ka Yang ,  Hao Wu

IPC: A61K31/4439

CPC classification number: A61K31/4439 ,  C07D401/14

Abstract: Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.

公开(公告)号：US11045458B2

公开(公告)日：2021-06-29

申请号：US16517943

申请日：2019-07-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Ka Yang ,  Hao Wu

IPC: C07D401/14 ,  C07D417/12 ,  A61P35/00 ,  A61P35/02 ,  A61K31/4439

Abstract: Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.

公开(公告)号：US20200022966A1

公开(公告)日：2020-01-23

申请号：US16517943

申请日：2019-07-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Ka Yang ,  Hao Wu

IPC: A61K31/4439

Abstract: Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.

公开(公告)号：US20220251071A1

公开(公告)日：2022-08-11

申请号：US17610896

申请日：2020-05-13

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Bo Wang ,  Suzhen Wu ,  Ka Yang

IPC: C07D401/14 ,  A61K31/496 ,  A61P35/00

Abstract: Compounds of the formula: pharmaceutical compositions containing the compounds, and methods of inhibiting neoplastic cell growth using the compounds and compositions.

公开(公告)号：US20200262819A1

公开(公告)日：2020-08-20

申请号：US16789887

申请日：2020-02-13

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Gabrielle N. Winston McPherson ,  Haibo Xie ,  Alan D. Attie ,  Mark Patrick Keller ,  Ka Yang

IPC: C07D403/06 ,  C07D401/14 ,  C07D413/14 ,  C07D409/06

Abstract: Described are benzoimidazole indolyl methane compounds, pharmaceutical compositions containing them, and use of the compounds to inhibit PCSK9-mediated ailments. The compounds have the structure:

公开(公告)号：US11059815B2

公开(公告)日：2021-07-13

申请号：US16800514

申请日：2020-02-25

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Ka Yang ,  Hao Wu ,  Zhongrui Zhang

IPC: C07D417/14 ,  C07D401/14

Abstract: Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.

公开(公告)号：US20210322398A1

公开(公告)日：2021-10-21

申请号：US17359857

申请日：2021-06-28

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weiping Tang ,  Ka Yang ,  Hao Wu

IPC: A61K31/4439

Abstract: Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.