公开(公告)号：US20180271470A1

公开(公告)日：2018-09-27

申请号：US15928812

申请日：2018-03-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Weibo Cai ,  Robert Nickles ,  Reinier Hernandez ,  Stephen Graves

IPC: A61B6/00 ,  A61K51/00 ,  A61K31/4422 ,  A61K31/18 ,  A61B6/03 ,  A61B5/00 ,  G06T7/00

CPC classification number: A61B6/5217 ,  A61B5/425 ,  A61B6/037 ,  A61B6/4057 ,  A61K31/18 ,  A61K31/4422 ,  A61K51/00 ,  A61K51/121 ,  G01R33/481 ,  G06T7/0014 ,  G06T2207/10104 ,  G06T2207/30092

Abstract: Methods for imaging beta cells in pancreatic tissue using radioisotopes of manganese, which may be referred to as radiomanganese, are described. Example radioisotopes of manganese include Mn-52g, Mn-52m, and Mn-51. As one example, radiomanganese can be used to image pancreatic beta cells, in which radiomanganese shows a preferential uptake. This provides for applications such as quantifying beta cell mass (e.g., functional beta cell mass), assessing transplant viability, and monitoring the efficacy of drug treatments. A pharmacological agent can be administered to modulate the uptake of divalent metals by the pancreatic beta cells, which can be correlated to a modulated uptake of radiomanganese to estimate pancreatic beta cell mass, function, or both.