公开(公告)号：US20100029544A1

公开(公告)日：2010-02-04

申请号：US12373210

申请日：2007-07-12

Applicant: Woei Ping Cheng ,  Colin Thompson

Inventor： Woei Ping Cheng ,  Colin Thompson

IPC: A61K47/34 ,  C08G73/02 ,  A61K38/02 ,  A61K31/7088 ,  A61K38/28 ,  A61K38/13 ,  A61K31/56

CPC classification number: A61K9/10 ,  A61K9/1075 ,  A61K9/5138 ,  C08F8/02 ,  C08F8/10 ,  C08F8/30 ,  C08F8/44 ,  C08F26/02 ,  C08F226/02

Abstract: Novel polyallylamine (PAA) based graft polymers are provided, including groups such as cholesteryl, cetyl, palmitoyl, which are adapted to deliver an entity that is normally of poor solubility in an aqueous medium, said entity being such as a drug, peptide, protein, or polynucleotide that is releasably contained within the said polymer, the resulting complex being of nanoparticle range sizes with a Tg of less than 37° C. and deliverable in aqueous media as micelles of typically 100 to 500 nm in hydrodynamic diameter, thereby offering a delivery vehicle capable of oral or parenteral administration that protects the entity from enzymes and critical pH changes.

Abstract translation: 提供了新的基于聚烯丙胺（PAA）的接枝聚合物，其包括诸如胆固醇基，鲸蜡基，棕榈酰基团，其适于递送在水性介质中通常具有差的溶解度的实体，所述实体例如药物，肽，蛋白质 或可释放地包含在所述聚合物内的多核苷酸，所得复合物的Tg范围尺寸小于37℃，并且可在水介质中作为流体动力学直径通常为100-500nm的胶束递送，由此提供 能够口服或肠胃外给药的输送载体，其保护实体免受酶和临界pH变化。

公开(公告)号：US20060107814A1

公开(公告)日：2006-05-25

申请号：US10905772

申请日：2005-01-20

Applicant: Colin Thompson

Inventor： Colin Thompson

IPC: B26D7/02

CPC classification number: B25B5/003 ,  B23H11/003 ,  B25B5/006 ,  B25B5/109 ,  B25B5/163 ,  Y10T83/7487

Abstract: A clamping device is provided for clamping one or more workpieces in a pre-determined position in precision cutting apparatus. The clamping device includes a first portion having attachment means provided thereon for allowing attachment of the same directly to a work surface of the apparatus in use, and a second portion which is capable of being engaged with the first portion. The second portion forms at least part of or is associated with clamping means for clamping the one or more workpieces. The vertical and/or horizontal orientation of the clamping device is entirely dependent on the vertical and/or horizontal orientation of the work surface of the precision cutting apparatus to which the clamping device is attached in use.

Abstract translation: 夹紧装置用于将一个或多个工件夹紧在精密切割装置中的预定位置。 夹紧装置包括第一部分，其具有设置在其上的附接装置，用于允许其直接附接到使用中的装置的工作表面;以及第二部分，其能够与第一部分接合。 第二部分形成用于夹持一个或多个工件的夹紧装置的至少一部分或与夹紧装置相关联。 夹紧装置的垂直和/或水平取向完全取决于夹紧装置在使用中附接到的精密切割装置的工作表面的垂直和/或水平取向。

公开(公告)号：US07790883B2

公开(公告)日：2010-09-07

申请号：US10581143

申请日：2007-02-14

Applicant: Michael Butters ,  Richard Wisedale ,  Matthew James Welham ,  Colin Thompson ,  Andrew Watts

Inventor： Michael Butters ,  Richard Wisedale ,  Matthew James Welham ,  Colin Thompson ,  Andrew Watts

IPC: C07D487/00 ,  C07D471/00 ,  C07D491/00

CPC classification number: C07D497/04 ,  C07D513/04

Abstract: A method for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof; from a compound of the formula: (IV); wherein L represents a leaving group.

Abstract translation: 一种制备式（I）化合物或其药学上可接受的盐或溶剂合物的方法; 由式（IV）表示的化合物： 其中L表示离去基团。