公开(公告)号：US20100029544A1

公开(公告)日：2010-02-04

申请号：US12373210

申请日：2007-07-12

Applicant: Woei Ping Cheng ,  Colin Thompson

Inventor： Woei Ping Cheng ,  Colin Thompson

IPC: A61K47/34 ,  C08G73/02 ,  A61K38/02 ,  A61K31/7088 ,  A61K38/28 ,  A61K38/13 ,  A61K31/56

CPC classification number: A61K9/10 ,  A61K9/1075 ,  A61K9/5138 ,  C08F8/02 ,  C08F8/10 ,  C08F8/30 ,  C08F8/44 ,  C08F26/02 ,  C08F226/02

Abstract: Novel polyallylamine (PAA) based graft polymers are provided, including groups such as cholesteryl, cetyl, palmitoyl, which are adapted to deliver an entity that is normally of poor solubility in an aqueous medium, said entity being such as a drug, peptide, protein, or polynucleotide that is releasably contained within the said polymer, the resulting complex being of nanoparticle range sizes with a Tg of less than 37° C. and deliverable in aqueous media as micelles of typically 100 to 500 nm in hydrodynamic diameter, thereby offering a delivery vehicle capable of oral or parenteral administration that protects the entity from enzymes and critical pH changes.

Abstract translation: 提供了新的基于聚烯丙胺（PAA）的接枝聚合物，其包括诸如胆固醇基，鲸蜡基，棕榈酰基团，其适于递送在水性介质中通常具有差的溶解度的实体，所述实体例如药物，肽，蛋白质 或可释放地包含在所述聚合物内的多核苷酸，所得复合物的Tg范围尺寸小于37℃，并且可在水介质中作为流体动力学直径通常为100-500nm的胶束递送，由此提供 能够口服或肠胃外给药的输送载体，其保护实体免受酶和临界pH变化。

公开(公告)号：US20120238487A1

公开(公告)日：2012-09-20

申请号：US13394117

申请日：2010-09-06

Applicant: Paul Kong Thoo Lin ,  Woei Ping Cheng ,  Clare Hoskins

Inventor： Paul Kong Thoo Lin ,  Woei Ping Cheng ,  Clare Hoskins

IPC: A61K47/34 ,  C08F228/02 ,  A61K31/7088 ,  C08F222/38 ,  C08B37/00 ,  A61K38/02

CPC classification number: C08B37/003 ,  A61K9/1075 ,  A61K47/18 ,  C08L5/08

Abstract: A polymer having a structure according to the following formula (I): wherein: A represents a hydrophilic group; B represents a hydrophobic aromatic group such as 5-dimethylamino-1-naphthalenesulfonyl (Dansyl), 9-fluorenylmethoxy carbonyl (Fmoc) and naphthalene (Naphth); D and E independently represent amine groups; F represents an amine group, the amine group being substituted with a B group and an A group, or the amine group being a quaternary ammonium moiety; wherein W, X, Y and Z each independently have values greater than or equal to (1), especially in the range of (1) to (10).

Abstract translation: 具有根据下式（I）的结构的聚合物：其中：A表示亲水基团; B表示疏水性芳基，例如5-二甲基氨基-1-萘磺酰（Dansyl），9-芴基甲氧羰基（Fmoc）和萘（萘）。 D和E独立地表示胺基; F表示胺基，胺基被B基和A基取代，或者胺基是季铵部分; 其中W，X，Y和Z各自独立地具有大于或等于（1）的值，特别是在（1）至（10）的范围内。