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1.发明授权1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives 失效1-苯基-2-杂芳基取代的苯并恶唑衍生物，它们用于生产药物的用途以及含有这些衍生物的药物制剂公开(公告)号：US06962932B2
公开(公告)日：2005-11-08
申请号：US10366688
申请日：2003-02-14
申请人： Thorsten Blume , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Bernd Elger , Herbert Schneider
发明人： Thorsten Blume , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Bernd Elger , Herbert Schneider
IPC分类号： C07D401/04 , C07D409/04 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/4184
CPC分类号： C07D401/04 , C07D409/04 , C07D413/14 , C07D417/14
摘要： New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
摘要翻译： 描述了新的苯并咪唑衍生物，它们的生产及其用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫疾病相关的疾病的药物的用途，以及含有新的苯并咪唑衍生物的药物制剂 。
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2.发明申请1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives 失效1-苯基-2-杂芳基取代的苯并咪唑衍生物，其用于生产药剂的用途以及含有这些衍生物的药物制剂公开(公告)号：US20050267160A1
公开(公告)日：2005-12-01
申请号：US11198098
申请日：2005-08-04
申请人： Thorsten Blume , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Bernd Elger , Herbert Schneider
发明人： Thorsten Blume , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Bernd Elger , Herbert Schneider
IPC分类号： C07D401/04 , C07D409/04 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/4184 , C07D43/02 , C07D49/02
CPC分类号： C07D401/04 , C07D409/04 , C07D413/14 , C07D417/14
摘要： New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
摘要翻译： 描述了新的苯并咪唑衍生物，它们的生产及其用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫疾病相关的疾病的药物的用途，以及含有新的苯并咪唑衍生物的药物制剂 。
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3.发明授权1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives 失效1-烷基-2-芳基 - 苯并咪唑衍生物，其用于生产药剂的用途以及含有这些衍生物的药物制剂公开(公告)号：US06855714B2
公开(公告)日：2005-02-15
申请号：US10189179
申请日：2002-07-05
申请人： Thorsten Blume , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Herbert Schneider , Bernd Elger
发明人： Thorsten Blume , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Herbert Schneider , Bernd Elger
IPC分类号： C07D235/18 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D521/00 , A61K31/4184
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D235/18 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要： The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds.
摘要翻译： 本发明涉及具有通式I的新的苯并咪唑衍生物，其中基团R 1，R 2，R 3，A，B和Y具有在说明书和权利要求书中指出的含义， 这些化合物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药剂，以及含有这些化合物的药物制剂。
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4.发明申请Microglia inhibitors for interrupting interleukin 12 and IFNgamma-mediated immune reactions 审中-公开用于中断白细胞介素12和IFNgamma介导的免疫反应的小胶质细胞抑制剂公开(公告)号：US20060211690A1
公开(公告)日：2006-09-21
申请号：US11351603
申请日：2006-02-09
申请人： Thorsten Blume , Wolf-Dietrich Doecke , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Bernd Elger , Herbert Schneider
发明人： Thorsten Blume , Wolf-Dietrich Doecke , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Bernd Elger , Herbert Schneider
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4184
CPC分类号： A61K31/4184
摘要： The invention describes the use of microglia inhibitors for the production of pharmaceutical agents that inhibit immune reactions that are mediated by monocytes, macrophages and T cells, and their use for treating T-cell-mediated immunological diseases and non-T-cell-mediated inflammation reactions.
摘要翻译： 本发明描述了小胶质细胞抑制剂用于制备抑制由单核细胞，巨噬细胞和T细胞介导的免疫反应的药物的用途及其用于治疗T细胞介导的免疫疾病和非T细胞介导的炎症的用途 反应。
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公开(公告)号：US20060205803A1
公开(公告)日：2006-09-14
申请号：US11305521
申请日：2005-12-16
IPC分类号： A61K31/4184 , C07D235/16
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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6.发明授权1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives 失效1-苯基-2-杂芳基取代的苯并咪唑衍生物，其用于生产药剂的用途以及含有这些衍生物的药物制剂公开(公告)号：US07683081B2
公开(公告)日：2010-03-23
申请号：US11198098
申请日：2005-08-04
申请人： Thorsten Blume , Bernd Elger , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Herbert Schneider
发明人： Thorsten Blume , Bernd Elger , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Herbert Schneider
IPC分类号： A61K31/4439 , A61K31/4184
CPC分类号： C07D401/04 , C07D409/04 , C07D413/14 , C07D417/14
摘要： New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
摘要翻译： 描述了新的苯并咪唑衍生物，它们的生产及其用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫疾病相关的疾病的药物的用途，以及含有新的苯并咪唑衍生物的药物制剂 。
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公开(公告)号：US07345075B2
公开(公告)日：2008-03-18
申请号：US11305521
申请日：2005-12-16
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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公开(公告)号：US07329679B2
公开(公告)日：2008-02-12
申请号：US11299135
申请日：2005-12-08
IPC分类号： A61K31/44 , A61K31/415
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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公开(公告)号：US07115645B2
公开(公告)日：2006-10-03
申请号：US09759360
申请日：2001-01-16
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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公开(公告)号：US20060094770A1
公开(公告)日：2006-05-04
申请号：US11299135
申请日：2005-12-08
IPC分类号： C07D235/12 , A61K31/4184
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
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