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公开(公告)号:US4628062A
公开(公告)日:1986-12-09
申请号:US682408
申请日:1984-12-17
申请人: Wolfgang Opitz , Bernhard Pelster , Romanis Fruchtmann , Udo Krupka , Walter Gauss , Hartmut Kiehne , Hermann Oediger
发明人: Wolfgang Opitz , Bernhard Pelster , Romanis Fruchtmann , Udo Krupka , Walter Gauss , Hartmut Kiehne , Hermann Oediger
IPC分类号: A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/18 , A61K31/19 , A61P29/00 , C07C45/00 , C07C50/24 , C07C50/32 , C07C50/38 , C07C67/00 , C07C213/00 , C07C225/30 , C07C233/32 , C07C301/00 , C07C311/00 , C07C313/00 , C07C323/38 , C07C50/14 , C07C97/22
摘要: New compounds of the formula ##STR1## in which R.sub.1 is an allylamino, acetylamino or propionylamino radical,R.sub.2 is hydrogen or a 2-methoxyethoxy or ethoxy radical,R.sub.3 is hydrogen or a sulphamoyl radical, andR.sub.4 is hydrogen,and of the formula ##STR2## in which R.sub.1 is a halogen atom or a free or substituted hydroxyl, sulphhydryl or amino group,R.sub.2 is a hydrogen atom, an alkyl radical, a halogen atom, or a free or substituted hydroxyl, sulphhydryl or amino group,R.sub.3 and R.sub.4 each independently is hydrogen, alkyl, hydroxyl, alkoxy, sulphonamido or halogen, with the proviso that R.sub.2, R.sub.3 and R.sub.4 are hydrogen when R.sub.1 is hydroxyl,exhibit anti-inflammatory activity.
摘要翻译: 式中,R1是烯丙基氨基,乙酰氨基或丙酰基氨基,R2是氢或2-甲氧基乙氧基或乙氧基的新化合物,其中R 3是氢或氨磺酰基,R 4是氢, IMAGE>其中R1是卤素原子或游离或取代的羟基,巯基或氨基,R2是氢原子,烷基,卤素原子或游离或取代的羟基,巯基或氨基,R3和R4 每个独立地是氢,烷基,羟基,烷氧基,磺酰胺基或卤素,条件是当R 1是羟基时,R 2,R 3和R 4是氢,表现出抗炎活性。