-
公开(公告)号：US08017739B2
公开(公告)日：2011-09-13
申请号：US11518558
申请日：2006-09-08
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。 本文还提供了产生缀合物的方法和缀合物的用途。
-
公开(公告)号：US08840879B2
公开(公告)日：2014-09-23
申请号：US13018648
申请日：2011-02-01
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 共轭物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价键形成。 本文还提供了产生缀合物的方法和缀合物的用途。
-
公开(公告)号：US20110200555A1
公开(公告)日：2011-08-18
申请号：US13018648
申请日：2011-02-01
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
IPC分类号： A61K38/21 , C07K14/565 , C07K14/535 , C12N9/96 , C07K14/81 , C07K14/755 , C07K1/107 , C12P21/00 , A61K38/19 , A61K38/48 , A61K38/57 , A61K38/37 , A61P25/00 , A61P7/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P17/00 , A61P7/04
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。 本文还提供了产生缀合物的方法和缀合物的用途。
-
公开(公告)号：US20090047251A1
公开(公告)日：2009-02-19
申请号：US11518558
申请日：2006-09-08
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。 本文还提供了产生缀合物的方法和缀合物的用途。
-
5.发明申请Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination 失效通过还原胺化制备的羟烷基淀粉和蛋白质的缀合物公开(公告)号：US20070134197A1
公开(公告)日：2007-06-14
申请号：US11518352
申请日：2006-09-08
申请人： Wolfram Eichner , Michele Orlando , Norbert Zander , Harald Conradt , Frank Hacket , Klaus Langer , Ronald Frank
发明人： Wolfram Eichner , Michele Orlando , Norbert Zander , Harald Conradt , Frank Hacket , Klaus Langer , Ronald Frank
CPC分类号： A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/202 , A61K38/212 , A61K38/215 , A61K38/37 , A61K38/42 , A61K38/446 , A61K38/4846 , A61K38/4866 , A61K38/55 , A61K47/61 , A61K51/065 , C08B31/00 , C08B31/006 , C08B31/12 , C08B31/185
摘要： Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.
摘要翻译： 提供羟烷基淀粉和蛋白质的结合物。 通过在羟基烷基淀粉的至少一个醛基或酮基或半缩醛基团或羟烷基淀粉的衍生物和蛋白质的至少一个氨基之间的还原胺化反应形成缀合物，使得羟烷基淀粉或 其衍生物通过偶氮甲碱键或氨基键与蛋白质共价连接。 还提供了生产这些缀合物的方法和缀合物的具体用途。
-
6.发明授权Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination 失效通过还原胺化制备的羟烷基淀粉和蛋白质的缀合物公开(公告)号：US08287850B2
公开(公告)日：2012-10-16
申请号：US11518352
申请日：2006-09-08
申请人： Wolfram Eichner , Michele Orlando , Norbert Zander , Harald S. Conradt , Frank Hacket , Klaus Langer , Ronald Frank
发明人： Wolfram Eichner , Michele Orlando , Norbert Zander , Harald S. Conradt , Frank Hacket , Klaus Langer , Ronald Frank
CPC分类号： A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/202 , A61K38/212 , A61K38/215 , A61K38/37 , A61K38/42 , A61K38/446 , A61K38/4846 , A61K38/4866 , A61K38/55 , A61K47/61 , A61K51/065 , C08B31/00 , C08B31/006 , C08B31/12 , C08B31/185
摘要： Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.
摘要翻译： 提供羟烷基淀粉和蛋白质的结合物。 通过在羟基烷基淀粉的至少一个醛基或酮基或半缩醛基团或羟烷基淀粉的衍生物和蛋白质的至少一个氨基之间的还原胺化反应形成缀合物，使得羟烷基淀粉或 其衍生物通过偶氮甲碱键或氨基键与蛋白质共价连接。 还提供了这些缀合物的制备方法和缀合物的具体用途。
-
公开(公告)号：US20080274948A1
公开(公告)日：2008-11-06
申请号：US10567266
申请日：2004-08-06
申请人： Wolfram Eichner , Helmut Knoller , Katherina Lutterbeck , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Sommermeyer , Eckard Grabenhorst
发明人： Wolfram Eichner , Helmut Knoller , Katherina Lutterbeck , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Sommermeyer , Eckard Grabenhorst
CPC分类号： C07K14/535 , A61K47/61
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a granulocyte colony stimulating factor protein (G-CSF) wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the methods of producing these conjugates and the use of these conjugates.
摘要翻译： 本发明涉及羟烷基淀粉和粒细胞集落刺激因子蛋白（G-CSF）的缀合物，其中这些缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价键形成。 本发明还涉及生产这些缀合物的方法和这些共轭物的用途。
-
8.发明申请公开(公告)号：US20100297078A1
公开(公告)日：2010-11-25
申请号：US12747972
申请日：2008-12-15
申请人： Frank Hacket , Wolfram Eichner , Helmut Knoller , Andreas Mitsch , Martin Schimmel , Norbert Zander , Franziska Hauschild
发明人： Frank Hacket , Wolfram Eichner , Helmut Knoller , Andreas Mitsch , Martin Schimmel , Norbert Zander , Franziska Hauschild
IPC分类号： A61K38/21 , C08B31/12 , C07K14/56 , C07K14/505 , C07K14/535 , C07H7/02 , C07K1/00 , A61K38/18 , A61P35/00 , A61P35/02 , A61P1/16 , A61P7/06 , A61P13/12 , A61P31/18
摘要： A method of producing a hydroxyalkyl starch (HAS) derivative, comprising a) reacting optionally oxidized hydroxyalkyl starch with a compound (D) comprising at least two functional groups —O—NH2 or a salt thereof, and b) reacting the hydroxyalkyl starch derivative obtained in step a) with a compound (L) comprising at least two functional groups W1 and W2 independently selected from the group consisting of an aldehyde group, a suitably protected aldehyde group, a keto group, and a suitably protected keto group.
摘要翻译： 一种制备羟烷基淀粉（HAS）衍生物的方法，包括：a）任选地氧化的羟烷基淀粉与包含至少两个官能团-O-NH 2或其盐的化合物（D）反应，和b）使获得的羟烷基淀粉衍生物 在步骤a）中，使用包含至少两个官能团W1和W2的化合物（L），其独立地选自醛基，适当保护的醛基，酮基和适当保护的酮基。
-
公开(公告)号：US20060019877A1
公开(公告)日：2006-01-26
申请号：US11078582
申请日：2005-03-11
申请人： Harald Conradt , Eckart Grabenhorst , Manfred Nimtz , Norbert Zander , Ronald Frank , Wolfram Eichner
发明人： Harald Conradt , Eckart Grabenhorst , Manfred Nimtz , Norbert Zander , Ronald Frank , Wolfram Eichner
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： C08B31/12 , A61K9/0021 , A61K38/00 , A61K47/61 , C07K14/505 , C07K14/53 , C07K14/5412 , C07K14/55 , C07K14/56 , C07K14/565 , C07K17/10 , C08B31/00 , C08B31/006 , C08B31/08 , C08B31/185 , C08H1/00
摘要： The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).
-
公开(公告)号：US20070087961A1
公开(公告)日：2007-04-19
申请号：US11530326
申请日：2006-09-08
申请人： Wolfram Eichner , Katharina Lutterbeck , Norbert Zander , Ronald Frank , Harald Conradt , Helmut Knoller
发明人： Wolfram Eichner , Katharina Lutterbeck , Norbert Zander , Ronald Frank , Harald Conradt , Helmut Knoller
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： C08B31/00 , A61K38/1816 , A61K47/61 , C08B31/006
摘要： Conjugates of hydroxyethyl starch and erythropoietin are provided. The conjugates comprise a linking compound that is covalently linked to erythropoietin and covalently linked to hydroxyethyl starch. Methods of producing the conjugates, and their use, also are provided.
摘要翻译： 提供了羟乙基淀粉和红细胞生成素的结合物。 缀合物包含与促红细胞生成素共价连接并与羟乙基淀粉共价连接的连接化合物。 还提供了制备缀合物的方法及其用途。
-
-
-
-
-
-
-
-
-
搜索结果
52 条记录 (耗时 0.068 秒)
