公开(公告)号：US07618661B2

公开(公告)日：2009-11-17

申请号：US11719292

申请日：2006-04-28

申请人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A01N65/00

CPC分类号： A61K36/22

摘要： Provided is a process for preparation of a Rhus verniciflua extract, comprising extracting allergen-removed Rhus verniciflua with a soluble solvent, thereby obtaining an extract, subjecting the thus-obtained extract to ultrafiltration to remove high-molecular weigh substances, concentrating and drying the resulting material, thereby obtaining extract powder and irradiating far-infrared to the extract powder, thereby improving anti-cancer activity. The Rhus verniciflua extract prepared according to the process of the present invention exhibits superior anti-cancer activity.

摘要翻译： 本发明提供了一种制备紫苏提取物的方法，其中包括用可溶性溶剂提取过敏原去除的紫草，从而获得提取物，将由此获得的提取物经过超滤以除去高分子量物质，浓缩并干燥所得的 从而获得提取物粉末并向提取物粉末照射远红外线，从而提高抗癌活性。 根据本发明的方法制备的紫薇提取物具有优异的抗癌活性。

公开(公告)号：US08551537B2

公开(公告)日：2013-10-08

申请号：US13519548

申请日：2010-12-27

申请人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

发明人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

IPC分类号： A01N65/00

CPC分类号： C07D311/30 ,  A61K31/352 ,  A61K31/353 ,  A61K36/22

摘要： The present invention relates to Rhus verniciflua Stokes extract having an increased content of an active flavonoid compound through a gas bubbling treatment, a method for preparing the Rhus verniciflua Stokes extract, and a method for converting fustin into fisetin through the gas bubbling treatment of a solution containing fustin. The method for preparing the Rhus verniciflua Stokes extract of the present invention can convert the conventional Rhus verniciflua Stokes extract having high content of fustin and low content of fisetin into a Rhus verniciflua Stokes extract having high content of fisetin. Therefore, the Rhus verniciflua Stokes extract of the present invention can be commercialized into natural anticancer agents, anticancer and cancer prevention food products, and health functional foods due to the excellent bioactivity thereof, and promote the development of relevant industries through the high added-value of Rhus verniciflua Stokes. In addition, the method for converting fustin into fisetin can be applied to other natural substances and be used as a method for enhancing the functionality thereof by increasing the content of a high active flavonoid, thereby becoming an enabling technology that can lead high-functionalization of natural substances.

摘要翻译： 本发明涉及通过气体鼓泡处理具有增加的活性类黄酮化合物含量的Rhus verniciflua Stokes提取物，用于制备Rhus verniciflua Stokes提取物的方法，以及通过气溶胶处理溶液将fustin转化成非瑟曲丁的方法 含有fustin。 制备本发明的紫荆提取物的方法可以将具有高fustin含量和低含量的fisetin的常规Rhus verniciflua Stokes提取物转化成具有高含量fisetin的Rhus verniciflua Stokes提取物。 因此，本发明的紫荆提取物由于其生物活性优异，可以商业化为天然抗癌剂，抗癌和癌症预防食品以及保健功能食品，通过高附加值促进相关产业的发展 Rhus verniciflua斯托克斯。 此外，将fustin转化为非瑟西汀的方法可以应用于其他天然物质，并且可以通过增加高活性类黄酮的含量而用作增强其功能的方法，从而成为可以导致高功能化的能力技术 天然物质

公开(公告)号：US20080233223A1

公开(公告)日：2008-09-25

申请号：US11570495

申请日：2005-09-08

申请人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A61K36/00 ,  A61P25/00

CPC分类号： A61K36/22

摘要： The present invention provides a process for preparing an extract of Rhus verniciflua by using water and organic solvents to extract active ingredients, which comprises (a) adding water or a mixture of water and alcohol as the solvent to Rhus verniciflua to extract the soluble components, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (b) re-extracting the solid fraction obtained in the previous step with highly purified ethanol, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (c) adding a saturated hydrocarbon having 5 to 7 carbon atoms to the solid fraction obtained in the previous step to dissolve allergy-inducing components, and then removing the hydrocarbon to obtain a solid fraction; and (d) adding water to the solid fraction obtained in the previous step to extract water-soluble components. The extract obtained according to the process for preparing an extract of Rhus verniciflua of the invention does not induce allergies, since toxic substances of lacquer are effectively removed, and various inherent active ingredients of lacquer can be extracted with high yield, compared with conventional processes.

摘要翻译： 本发明提供了一种通过使用水和有机溶剂提取活性成分来制备紫苏提取物的方法，其包括（a）将水或水和醇的混合物作为溶剂加入到紫苏中以提取可溶性成分， 然后过滤所得产物以获得滤液，并浓缩并干燥滤液以获得固体部分; （b）用高纯度乙醇重新萃取上一步得到的固体馏分，然后过滤得到的产物，得到滤液，浓缩并干燥滤液得到固体部分; （c）向前述步骤中得到的固体成分加入碳原子数为5〜7的饱和烃，以溶解过敏诱导成分，然后除去烃，得到固体成分; 和（d）向前述步骤中得到的固体部分加水，以提取水溶性成分。 根据制备本发明的提取物的方法获得的提取物不会诱导过敏，因为与常规方法相比，有效除去有毒物质的漆，并且能够以高产率提取各种固有的漆的活性成分。

公开(公告)号：US20120283322A1

公开(公告)日：2012-11-08

申请号：US13519548

申请日：2010-12-27

申请人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

发明人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

IPC分类号： C07D311/30 ,  A61K35/00 ,  A61K31/352

CPC分类号： C07D311/30 ,  A61K31/352 ,  A61K31/353 ,  A61K36/22

摘要： The present invention relates to Rhus verniciflua Stokes extract having an increased content of an active flavonoid compound through a gas bubbling treatment, a method for preparing the Rhus verniciflua Stokes extract, and a method for converting fustin into fisetin through the gas bubbling treatment of a solution containing fustin. The method for preparing the Rhus verniciflua Stokes extract of the present invention can convert the conventional Rhus verniciflua Stokes extract having high content of fustin and low content of fisetin into a Rhus verniciflua Stokes extract having high content of fisetin. Therefore, the Rhus verniciflua Stokes extract of the present invention can be commercialized into natural anticancer agents, anticancer and cancer prevention food products, and health functional foods due to the excellent bioactivity thereof, and promote the development of relevant industries through the high added-value of Rhus verniciflua Stokes. In addition, the method for converting fustin into fisetin can be applied to other natural substances and be used as a method for enhancing the functionality thereof by increasing the content of a high active flavonoid, thereby becoming an enabling technology that can lead high-functionalization of natural substances.

摘要翻译： 本发明涉及通过气体鼓泡处理具有增加的活性类黄酮化合物含量的Rhus verniciflua Stokes提取物，用于制备Rhus verniciflua Stokes提取物的方法，以及通过气溶胶处理溶液将fustin转化成非瑟曲丁的方法 含有fustin。 制备本发明的紫荆提取物的方法可以将具有高fustin含量和低含量的fisetin的常规Rhus verniciflua Stokes提取物转化成具有高含量fisetin的Rhus verniciflua Stokes提取物。 因此，本发明的紫荆提取物由于其生物活性优异，可以商业化为天然抗癌剂，抗癌和癌症预防食品以及保健功能食品，通过高附加值促进相关产业的发展 Rhus verniciflua斯托克斯。 此外，将fustin转化为非瑟西汀的方法可以应用于其他天然物质，并且可以通过增加高活性类黄酮的含量而用作增强其功能的方法，从而成为可以导致高功能化的能力技术 天然物质

公开(公告)号：US20090053330A1

公开(公告)日：2009-02-26

申请号：US11719292

申请日：2006-04-28

申请人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A61K36/22

CPC分类号： A61K36/22

摘要： Provided is a process for preparation of a Rhus verniciflua extract, comprising extracting allergen-removed Rhus verniciflua with a soluble solvent, thereby obtaining an extract, subjecting the thus-obtained extract to ultrafiltration to remove high-molecular weigh substances, concentrating and drying the resulting material, thereby obtaining extract powder and irradiating far-infrared to the extract powder, thereby improving anti-cancer activity. The Rhus verniciflua extract prepared according to the process of the present invention exhibits superior anti-cancer activity.

摘要翻译： 本发明提供了一种制备紫苏提取物的方法，其中包括用可溶性溶剂提取过敏原去除的紫草，从而获得提取物，将由此获得的提取物经过超滤以除去高分子量物质，浓缩并干燥所得的 从而获得提取物粉末并向提取物粉末照射远红外线，由此提高抗癌活性。 根据本发明的方法制备的紫薇提取物具有优异的抗癌活性。

公开(公告)号：US07629006B2

公开(公告)日：2009-12-08

申请号：US11570495

申请日：2005-09-08

申请人： Won-Cheol Chol ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Chol ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A61K36/00

CPC分类号： A61K36/22

摘要： The present invention provides a process for preparing an extract of Rhus verniciflua by using water and organic solvents to extract active ingredients, which comprises (a) adding water or a mixture of water and alcohol as the solvent to Rhus verniciflua to extract the soluble components, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (b) re-extracting the solid fraction obtained in the previous step with highly purified ethanol, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (c) adding a saturated hydrocarbon having 5 to 7 carbon atoms to the solid fraction obtained in the previous step to dissolve allergy-inducing components, and then removing the hydrocarbon to obtain a solid fraction; and (d) adding water to the solid fraction obtained in the previous step to extract water-soluble components. The extract obtained according to the process for preparing an extract of Rhus verniciflua of the invention does not induce allergies, since toxic substances of lacquer are effectively removed, and various inherent active ingredients of lacquer can be extracted with high yield, compared with conventional processes.

摘要翻译： 本发明提供了一种通过使用水和有机溶剂提取活性成分来制备紫苏提取物的方法，其包括（a）将水或水和醇的混合物作为溶剂加入到紫苏中以提取可溶性成分， 然后过滤所得产物以获得滤液，并浓缩并干燥滤液以获得固体部分; （b）用高纯度乙醇重新萃取上一步得到的固体馏分，然后过滤得到的产物，得到滤液，浓缩并干燥滤液得到固体部分; （c）向前述步骤中得到的固体成分加入碳原子数为5〜7的饱和烃，以溶解过敏诱导成分，然后除去烃，得到固体成分; 和（d）向前述步骤中得到的固体部分加水，以提取水溶性成分。 根据制备本发明的提取物的方法获得的提取物不会诱导过敏，因为与常规方法相比，有效除去有毒物质的漆，并且能够以高产率提取各种固有的漆的活性成分。