公开(公告)号：US07629006B2

公开(公告)日：2009-12-08

申请号：US11570495

申请日：2005-09-08

申请人： Won-Cheol Chol ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Chol ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A61K36/00

CPC分类号： A61K36/22

摘要： The present invention provides a process for preparing an extract of Rhus verniciflua by using water and organic solvents to extract active ingredients, which comprises (a) adding water or a mixture of water and alcohol as the solvent to Rhus verniciflua to extract the soluble components, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (b) re-extracting the solid fraction obtained in the previous step with highly purified ethanol, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (c) adding a saturated hydrocarbon having 5 to 7 carbon atoms to the solid fraction obtained in the previous step to dissolve allergy-inducing components, and then removing the hydrocarbon to obtain a solid fraction; and (d) adding water to the solid fraction obtained in the previous step to extract water-soluble components. The extract obtained according to the process for preparing an extract of Rhus verniciflua of the invention does not induce allergies, since toxic substances of lacquer are effectively removed, and various inherent active ingredients of lacquer can be extracted with high yield, compared with conventional processes.

摘要翻译： 本发明提供了一种通过使用水和有机溶剂提取活性成分来制备紫苏提取物的方法，其包括（a）将水或水和醇的混合物作为溶剂加入到紫苏中以提取可溶性成分， 然后过滤所得产物以获得滤液，并浓缩并干燥滤液以获得固体部分; （b）用高纯度乙醇重新萃取上一步得到的固体馏分，然后过滤得到的产物，得到滤液，浓缩并干燥滤液得到固体部分; （c）向前述步骤中得到的固体成分加入碳原子数为5〜7的饱和烃，以溶解过敏诱导成分，然后除去烃，得到固体成分; 和（d）向前述步骤中得到的固体部分加水，以提取水溶性成分。 根据制备本发明的提取物的方法获得的提取物不会诱导过敏，因为与常规方法相比，有效除去有毒物质的漆，并且能够以高产率提取各种固有的漆的活性成分。

公开(公告)号：US08551537B2

公开(公告)日：2013-10-08

申请号：US13519548

申请日：2010-12-27

申请人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

发明人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

IPC分类号： A01N65/00

CPC分类号： C07D311/30 ,  A61K31/352 ,  A61K31/353 ,  A61K36/22

摘要： The present invention relates to Rhus verniciflua Stokes extract having an increased content of an active flavonoid compound through a gas bubbling treatment, a method for preparing the Rhus verniciflua Stokes extract, and a method for converting fustin into fisetin through the gas bubbling treatment of a solution containing fustin. The method for preparing the Rhus verniciflua Stokes extract of the present invention can convert the conventional Rhus verniciflua Stokes extract having high content of fustin and low content of fisetin into a Rhus verniciflua Stokes extract having high content of fisetin. Therefore, the Rhus verniciflua Stokes extract of the present invention can be commercialized into natural anticancer agents, anticancer and cancer prevention food products, and health functional foods due to the excellent bioactivity thereof, and promote the development of relevant industries through the high added-value of Rhus verniciflua Stokes. In addition, the method for converting fustin into fisetin can be applied to other natural substances and be used as a method for enhancing the functionality thereof by increasing the content of a high active flavonoid, thereby becoming an enabling technology that can lead high-functionalization of natural substances.

摘要翻译： 本发明涉及通过气体鼓泡处理具有增加的活性类黄酮化合物含量的Rhus verniciflua Stokes提取物，用于制备Rhus verniciflua Stokes提取物的方法，以及通过气溶胶处理溶液将fustin转化成非瑟曲丁的方法 含有fustin。 制备本发明的紫荆提取物的方法可以将具有高fustin含量和低含量的fisetin的常规Rhus verniciflua Stokes提取物转化成具有高含量fisetin的Rhus verniciflua Stokes提取物。 因此，本发明的紫荆提取物由于其生物活性优异，可以商业化为天然抗癌剂，抗癌和癌症预防食品以及保健功能食品，通过高附加值促进相关产业的发展 Rhus verniciflua斯托克斯。 此外，将fustin转化为非瑟西汀的方法可以应用于其他天然物质，并且可以通过增加高活性类黄酮的含量而用作增强其功能的方法，从而成为可以导致高功能化的能力技术 天然物质

公开(公告)号：US20080233223A1

公开(公告)日：2008-09-25

申请号：US11570495

申请日：2005-09-08

申请人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A61K36/00 ,  A61P25/00

CPC分类号： A61K36/22

摘要： The present invention provides a process for preparing an extract of Rhus verniciflua by using water and organic solvents to extract active ingredients, which comprises (a) adding water or a mixture of water and alcohol as the solvent to Rhus verniciflua to extract the soluble components, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (b) re-extracting the solid fraction obtained in the previous step with highly purified ethanol, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (c) adding a saturated hydrocarbon having 5 to 7 carbon atoms to the solid fraction obtained in the previous step to dissolve allergy-inducing components, and then removing the hydrocarbon to obtain a solid fraction; and (d) adding water to the solid fraction obtained in the previous step to extract water-soluble components. The extract obtained according to the process for preparing an extract of Rhus verniciflua of the invention does not induce allergies, since toxic substances of lacquer are effectively removed, and various inherent active ingredients of lacquer can be extracted with high yield, compared with conventional processes.

摘要翻译： 本发明提供了一种通过使用水和有机溶剂提取活性成分来制备紫苏提取物的方法，其包括（a）将水或水和醇的混合物作为溶剂加入到紫苏中以提取可溶性成分， 然后过滤所得产物以获得滤液，并浓缩并干燥滤液以获得固体部分; （b）用高纯度乙醇重新萃取上一步得到的固体馏分，然后过滤得到的产物，得到滤液，浓缩并干燥滤液得到固体部分; （c）向前述步骤中得到的固体成分加入碳原子数为5〜7的饱和烃，以溶解过敏诱导成分，然后除去烃，得到固体成分; 和（d）向前述步骤中得到的固体部分加水，以提取水溶性成分。 根据制备本发明的提取物的方法获得的提取物不会诱导过敏，因为与常规方法相比，有效除去有毒物质的漆，并且能够以高产率提取各种固有的漆的活性成分。

公开(公告)号：US07618661B2

公开(公告)日：2009-11-17

申请号：US11719292

申请日：2006-04-28

申请人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A01N65/00

CPC分类号： A61K36/22

摘要： Provided is a process for preparation of a Rhus verniciflua extract, comprising extracting allergen-removed Rhus verniciflua with a soluble solvent, thereby obtaining an extract, subjecting the thus-obtained extract to ultrafiltration to remove high-molecular weigh substances, concentrating and drying the resulting material, thereby obtaining extract powder and irradiating far-infrared to the extract powder, thereby improving anti-cancer activity. The Rhus verniciflua extract prepared according to the process of the present invention exhibits superior anti-cancer activity.

摘要翻译： 本发明提供了一种制备紫苏提取物的方法，其中包括用可溶性溶剂提取过敏原去除的紫草，从而获得提取物，将由此获得的提取物经过超滤以除去高分子量物质，浓缩并干燥所得的 从而获得提取物粉末并向提取物粉末照射远红外线，从而提高抗癌活性。 根据本发明的方法制备的紫薇提取物具有优异的抗癌活性。

公开(公告)号：US20120283322A1

公开(公告)日：2012-11-08

申请号：US13519548

申请日：2010-12-27

申请人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

发明人： Sang-Jae Park ,  Kyung-Hee Kim ,  Myung-Jae Shin ,  Sang-Seok Lee ,  Byung-Sik Kang ,  Won-Cheol Choi ,  Sung-Pil Kwon

IPC分类号： C07D311/30 ,  A61K35/00 ,  A61K31/352

CPC分类号： C07D311/30 ,  A61K31/352 ,  A61K31/353 ,  A61K36/22

摘要： The present invention relates to Rhus verniciflua Stokes extract having an increased content of an active flavonoid compound through a gas bubbling treatment, a method for preparing the Rhus verniciflua Stokes extract, and a method for converting fustin into fisetin through the gas bubbling treatment of a solution containing fustin. The method for preparing the Rhus verniciflua Stokes extract of the present invention can convert the conventional Rhus verniciflua Stokes extract having high content of fustin and low content of fisetin into a Rhus verniciflua Stokes extract having high content of fisetin. Therefore, the Rhus verniciflua Stokes extract of the present invention can be commercialized into natural anticancer agents, anticancer and cancer prevention food products, and health functional foods due to the excellent bioactivity thereof, and promote the development of relevant industries through the high added-value of Rhus verniciflua Stokes. In addition, the method for converting fustin into fisetin can be applied to other natural substances and be used as a method for enhancing the functionality thereof by increasing the content of a high active flavonoid, thereby becoming an enabling technology that can lead high-functionalization of natural substances.

摘要翻译： 本发明涉及通过气体鼓泡处理具有增加的活性类黄酮化合物含量的Rhus verniciflua Stokes提取物，用于制备Rhus verniciflua Stokes提取物的方法，以及通过气溶胶处理溶液将fustin转化成非瑟曲丁的方法 含有fustin。 制备本发明的紫荆提取物的方法可以将具有高fustin含量和低含量的fisetin的常规Rhus verniciflua Stokes提取物转化成具有高含量fisetin的Rhus verniciflua Stokes提取物。 因此，本发明的紫荆提取物由于其生物活性优异，可以商业化为天然抗癌剂，抗癌和癌症预防食品以及保健功能食品，通过高附加值促进相关产业的发展 Rhus verniciflua斯托克斯。 此外，将fustin转化为非瑟西汀的方法可以应用于其他天然物质，并且可以通过增加高活性类黄酮的含量而用作增强其功能的方法，从而成为可以导致高功能化的能力技术 天然物质

公开(公告)号：US20090053330A1

公开(公告)日：2009-02-26

申请号：US11719292

申请日：2006-04-28

申请人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

发明人： Won-Cheol Choi ,  Sang-Jae Park ,  Sung-Pil Kwon

IPC分类号： A61K36/22

CPC分类号： A61K36/22

摘要： Provided is a process for preparation of a Rhus verniciflua extract, comprising extracting allergen-removed Rhus verniciflua with a soluble solvent, thereby obtaining an extract, subjecting the thus-obtained extract to ultrafiltration to remove high-molecular weigh substances, concentrating and drying the resulting material, thereby obtaining extract powder and irradiating far-infrared to the extract powder, thereby improving anti-cancer activity. The Rhus verniciflua extract prepared according to the process of the present invention exhibits superior anti-cancer activity.

摘要翻译： 本发明提供了一种制备紫苏提取物的方法，其中包括用可溶性溶剂提取过敏原去除的紫草，从而获得提取物，将由此获得的提取物经过超滤以除去高分子量物质，浓缩并干燥所得的 从而获得提取物粉末并向提取物粉末照射远红外线，由此提高抗癌活性。 根据本发明的方法制备的紫薇提取物具有优异的抗癌活性。

公开(公告)号：US20080058776A1

公开(公告)日：2008-03-06

申请号：US11515738

申请日：2006-09-06

申请人： Yung-Ho Jo ,  Dong-Jun Kim ,  Jaesoon Choi ,  Jae-Gahb Park ,  Young-Woo Kim ,  Sang-Jae Park

发明人： Yung-Ho Jo ,  Dong-Jun Kim ,  Jaesoon Choi ,  Jae-Gahb Park ,  Young-Woo Kim ,  Sang-Jae Park

IPC分类号： A61B17/00

CPC分类号： A61B34/70 ,  A61B34/30 ,  A61B34/37 ,  A61B2034/305

摘要： A robotic surgical system includes a master manipulator, slave robotic units having a surgical instrument for performing a Minimal Invasive Surgery (MIS), and a control system for electrically associating the master manipulator with the slave robotic units. The slave robotic unit includes the driving mechanisms which are more compact than those of the conventional MIS system. In use, the existing surgical instruments used in the conventional MIS procedure can be applied to the slave robotic unit. Moreover, by using the pivotal mechanism of the driving mechanisms, a pivot point of the surgical instrument is allowed to be shifted with respect to an incision of a patient. So, the patient's tissues surrounding the surgical instrument are not excessively affected by the surgical instrument during the procedure.

摘要翻译： 机器人手术系统包括主操纵器，具有用于执行微创手术（MIS）的手术器械的从属机器人单元以及用于将主操纵器与从机器人单元电联动的控制系统。 从机器人单元包括比常规MIS系统更紧凑的驱动机构。 在使用中，常规MIS程序中使用的现有手术器械可以应用于从动机器人单元。 此外，通过使用驱动机构的枢转机构，允许手术器械的枢转点相对于患者的切口移动。 因此，手术器械周围的患者组织不会被手术器械过度影响。

公开(公告)号：US08377049B2

公开(公告)日：2013-02-19

申请号：US12583734

申请日：2009-08-24

申请人： Seong-Yeon Cho ,  Sang-Jae Park ,  Kwang-Gi Kim

发明人： Seong-Yeon Cho ,  Sang-Jae Park ,  Kwang-Gi Kim

IPC分类号： A61B18/18

CPC分类号： A61B17/2812 ,  A61B90/361 ,  A61B2090/306 ,  A61B2217/005 ,  A61M1/008

摘要： Provided is a surgical instrument which can provide a field of view over a surgical site by sucking blood from a bleeding site during surgery on body tissue of a patient and monitoring a dark and deep surgical site, which an operator cannot see with his or her naked eye, with a small camera. The surgical instrument has substantially the same shape as a pair of scissors and includes a first body, a second body having a shape symmetrical to that of the first body, a hinge to which the first and second bodies cross and are rotatably coupled, and a photographing unit provided in the hinge to photograph a surgical site between front ends of the first and second bodies. The photographing unit may include a camera mounted in the hinge such that lens of the camera can be exposed through the center of the front surface of the hinge and configured to transmit a photographed image data to a monitor.

摘要翻译： 提供了一种手术器械，其可以通过在患者的身体组织的手术期间从出血部位抽吸血液并监测操作者不能用他或她的裸体看不见的深色和深色手术部位来提供外科手术部位的视野 眼睛，用一个小相机。 手术器具具有与一对剪刀大致相同的形状，并且包括第一主体，具有与第一主体相对应的形状的第二主体，第一和第二主体交叉并可旋转地联接的铰链，以及 设置在所述铰链中以拍摄所述第一和第二主体的前端之间的手术部位。 拍摄单元可以包括安装在铰链中的相机，使得照相机的透镜可以通过铰链的前表面的中心露出并且被配置为将拍摄的图像数据传输到监视器。

公开(公告)号：US08231610B2

公开(公告)日：2012-07-31

申请号：US11515738

申请日：2006-09-06

申请人： Yung-Ho Jo ,  Dong-Jun Kim ,  Jaesoon Choi ,  Jae-Gahb Park ,  Young-Woo Kim ,  Sang-Jae Park

发明人： Yung-Ho Jo ,  Dong-Jun Kim ,  Jaesoon Choi ,  Jae-Gahb Park ,  Young-Woo Kim ,  Sang-Jae Park

IPC分类号： A61B19/00

CPC分类号： A61B34/70 ,  A61B34/30 ,  A61B34/37 ,  A61B2034/305

摘要： A robotic surgical system includes a master manipulator, slave robotic units having a surgical instrument for performing a Minimal Invasive Surgery (MIS), and a control system for electrically associating the master manipulator with the slave robotic units. The slave robotic unit includes the driving mechanisms which are more compact than those of the conventional MIS system. In use, the existing surgical instruments used in the conventional MIS procedure can be applied to the slave robotic unit. Moreover, by using the pivotal mechanism of the driving mechanisms, a pivot point of the surgical instrument is allowed to be shifted with respect to an incision of a patient. So, the patient's tissues surrounding the surgical instrument are not excessively affected by the surgical instrument during the procedure.

摘要翻译： 机器人手术系统包括主操纵器，具有用于执行微创手术（MIS）的手术器械的从属机器人单元以及用于将主操纵器与从机器人单元电联动的控制系统。 从机器人单元包括比常规MIS系统更紧凑的驱动机构。 在使用中，常规MIS程序中使用的现有手术器械可以应用于从动机器人单元。 此外，通过使用驱动机构的枢转机构，允许手术器械的枢转点相对于患者的切口移动。 因此，手术器械周围的患者组织不会被手术器械过度影响。

公开(公告)号：US10581118B2

公开(公告)日：2020-03-03

申请号：US15632153

申请日：2017-06-23

申请人： Gao Liu ,  Hui Zhao ,  Sang-Jae Park

发明人： Gao Liu ,  Hui Zhao ,  Sang-Jae Park

IPC分类号： H01M10/0568 ,  H01M10/0569 ,  H01M10/0525 ,  H01M4/38 ,  H01M4/58 ,  H01M4/587 ,  H01M10/052

摘要： A homologous series of cyclic carbonate or propylene carbonate (PC) analog solvents with increasing length of linear alkyl substitutes were synthesized and used as co-solvents with PC for graphite based lithium ion half cells. A graphite anode reaches a capacity around 310 mAh/g in PC and its analog co-solvents with 99.95% Coulombic efficiency. Cyclic carbonate co-solvents with longer alkyl chains are able to prevent exfoliation of graphite when used as co-solvents with PC. The cyclic carbonate co-solvents of PC compete for solvation of Li ion with PC solvent, delaying PC co-intercalation. Reduction products of PC on graphite surfaces via single-electron path form a stable Solid Electrolyte Interphase (SEI), which allows the reversible cycling of graphite.