公开(公告)号：US20170296159A1

公开(公告)日：2017-10-19

申请号：US15491107

申请日：2017-04-19

Applicant: Worcester Polytechnic Institute ,  University of Massachusetts

Inventor： Jacquelyne DiTroia ,  Caroline Mazzola ,  Andres Monterroso ,  Patricia Swierk ,  Kristen Billiar ,  Arriyan Samandar Dowlatshahi ,  Raymond M. Dunn

IPC: A61B17/02 ,  A61B17/32 ,  A61B17/00

CPC classification number: A61B17/0206 ,  A61B2017/00407 ,  A61B2017/00902 ,  A61B2017/00911 ,  A61B2017/0092 ,  A61B2017/320044

Abstract: A surgical appliance includes a pair of opposed prongs slideably disposed on an elongated locking track for retracting neurovascular and musculotendinous anatomical structures through an incision for affording access to deeper structures for inserting osteosynthesis hardware in the surgical treatment of a distal radius fracture or other surgical procedure. The prongs extend from retractors that traverse the locking track for opposed linear movement while recessed in a surgical working region accessible through an incision. The prongs terminate in curvatures defining a void that gather and engage the elongated anatomical structures on top of the skeletal members receiving the plate. The prongs draw back the tendons, blood vessels and nerve structures to allow unimpeded surgical access for manipulating and attaching skeletal and soft tissue members and/or appliances. The device retracts anatomical structures along a linear track for a fixed locking engagement maintaining a surgical gap without direct manual assistance.

公开(公告)号：US09662415B2

公开(公告)日：2017-05-30

申请号：US14795537

申请日：2015-07-09

Applicant: Worcester Polytechnic Institute

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61K35/14 ,  C07K14/00 ,  A61L27/22 ,  A61L31/04 ,  A61K38/36

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

公开(公告)号：US20160095954A1

公开(公告)日：2016-04-07

申请号：US14795537

申请日：2015-07-09

Applicant: Worcester Polytechnic Institute

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61L27/22

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract translation: 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。

公开(公告)号：US20150025009A1

公开(公告)日：2015-01-22

申请号：US14445930

申请日：2014-07-29

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61K38/36

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract translation: 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。