公开(公告)号：US20160303283A1

公开(公告)日：2016-10-20

申请号：US15099957

申请日：2016-04-15

Applicant: Worcester Polytechnic Institute

Inventor： Keith A. Gagnon ,  Thomas J. Moutinho, JR. ,  Kevin A. Reyer ,  Alyssa L. Bornstein ,  Megan O'Brien ,  George D. Pins ,  Glenn R. Gaudette

IPC: A61L27/22 ,  A61L27/54 ,  A61L27/38 ,  A61L27/52 ,  B29C33/38 ,  G03F7/32 ,  B29C41/00 ,  B29C41/42 ,  B29C65/00 ,  B29C41/20 ,  G03F7/20 ,  G03F7/38 ,  A61K35/34 ,  B29C33/40

CPC classification number: A61L27/225 ,  A61K35/34 ,  A61L27/3826 ,  A61L27/52 ,  A61L27/54 ,  B29C33/3842 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/405 ,  B29C33/424 ,  B29C41/003 ,  B29C41/20 ,  B29C41/42 ,  B29C65/002 ,  B29K2089/00 ,  B29K2883/00 ,  B29L2031/753 ,  C12N2533/56 ,  G03F7/0002 ,  G03F7/2002 ,  G03F7/32 ,  G03F7/38

Abstract: A scaffold, a method of using the scaffold and a method of preparing the scaffold which may promote the growth or survival of cells and tissues. The scaffold comprises at least one microvascular layer formed from a thin-film fibrin, the microvascular layer configured to sustain and promote growth of cells and having one or more microfluidics channels embedded in the microvascular layer, the channels configured to contain nutrients needed for growth of the cells, and the channels configured to permit diffusion of the nutrients from the channels to the cells.

Abstract translation: 支架，使用支架的方法和制备可促进细胞和组织的生长或存活的支架的方法。 所述支架包括由薄膜纤维蛋白形成的至少一个微血管层，所述微血管层被配置为维持和促进细胞的生长并且具有嵌入在所述微血管层中的一个或多个微流体通道，所述通道被配置成含有生长所需的营养物质 细胞和被配置成允许营养物从通道扩散到细胞的通道。

公开(公告)号：US20150005739A1

公开(公告)日：2015-01-01

申请号：US14296109

申请日：2014-06-04

Applicant: Worcester Polytechnic Institute

Inventor： Glenn Gaudette ,  George D. Pins ,  Marsha Rolle ,  Jacques P. Guyette ,  Kevin Cornwall

IPC: A61L31/04 ,  A61L31/16 ,  C12N11/02

CPC classification number: A61L31/046 ,  A61B17/0469 ,  A61B17/06 ,  A61B17/06166 ,  A61B2017/00243 ,  A61B2017/00893 ,  A61L27/225 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3873 ,  A61L31/16 ,  A61L2430/20 ,  C12N5/0068 ,  C12N11/02 ,  C12N2533/56

Abstract: Compositions that include microthreads are provided. The compositions can be fully or partially encased in a sleeve along at least a portion of their length and can include biological cells and, optionally, therapeutic agents. Also provided are methods for using the compositions to repair or ameliorate damaged or defective tissue, including cardiovascular tissue (e.g., the myocardium).

Abstract translation: 提供包括微丝的组合。 组合物可以沿其长度的至少一部分完全或部分地包封在套管中，并且可以包括生物细胞和任选的治疗剂。 还提供了使用组合物来修复或改善包括心血管组织（例如心肌）的损伤或缺陷组织的方法。

公开(公告)号：US09662415B2

公开(公告)日：2017-05-30

申请号：US14795537

申请日：2015-07-09

Applicant: Worcester Polytechnic Institute

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61K35/14 ,  C07K14/00 ,  A61L27/22 ,  A61L31/04 ,  A61K38/36

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

公开(公告)号：US20160095954A1

公开(公告)日：2016-04-07

申请号：US14795537

申请日：2015-07-09

Applicant: Worcester Polytechnic Institute

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61L27/22

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract translation: 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。

公开(公告)号：US20150025009A1

公开(公告)日：2015-01-22

申请号：US14445930

申请日：2014-07-29

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61K38/36

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract translation: 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。