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公开(公告)号：US09981045B2
公开(公告)日：2018-05-29
申请号：US14695582
申请日：2015-04-24
申请人： Wyeth LLC
发明人： A. Krishna Prasad
IPC分类号： A61K39/385 , A61K47/48 , A61K39/09 , A61K39/00
CPC分类号： A61K47/646 , A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.
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2.发明申请公开(公告)号：US20150231270A1
公开(公告)日：2015-08-20
申请号：US14695582
申请日：2015-04-24
申请人： Wyeth LLC
发明人： A. Krishna Prasad
CPC分类号： A61K47/646 , A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.
摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。 还提供了制备包含肺炎链球菌血清型19A多糖的免疫原性缀合物的方法，其中血清型19A多糖与载体蛋白共冻干，并通过还原胺化机制在二甲基亚砜（DMSO）中进行偶联。
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公开(公告)号：US11969474B2
公开(公告)日：2024-04-30
申请号：US15972758
申请日：2018-05-07
申请人： Wyeth LLC
发明人： A. Krishna Prasad
CPC分类号： A61K47/646 , A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.
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4.发明授权公开(公告)号：US09480736B2
公开(公告)日：2016-11-01
申请号：US14520108
申请日：2014-10-21
申请人： Wyeth LLC
IPC分类号： A61K39/00 , A61K39/09 , A61K39/385
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6031 , A61K2039/6037
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.
摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。 还描述了一种用于制备包含与载体蛋白共价连接的肺炎链球菌血清型1多糖的免疫原性缀合物的方法，该方法包括在碱性pH缓冲液中通过轻度水解部分脱-O-乙酰化多糖。
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5.发明申请COMPOSITIONS AND METHODS FOR PREPARING STAPHYLOCOCCUS AUREUS SEROTYPE 5 AND 8 CAPSULAR POLYSACCHARIDE CONJUGATE IMMUNOGENIC COMPOSITIONS 审中-公开组合物及其制备方法用于制备油菜黄连蛋白5和8聚糖多糖共沉淀物免疫组合物公开(公告)号：US20160022798A1
公开(公告)日：2016-01-28
申请号：US14811017
申请日：2015-07-28
申请人： Wyeth LLC
发明人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
IPC分类号： A61K39/085 , C08B37/00 , A61K47/48
CPC分类号： A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , C08B37/00
摘要： The present invention relates to immunogenic conjugates comprising S. auerus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
摘要翻译： 本发明涉及免疫原性缀合物，其包含与载体蛋白缀合的澳氏血清型5和8荚膜多糖及其制备和使用方法。 制备本发明的免疫原性缀合物的方法包括使用涉及1,1-碳基 - 二-1,2,4-三唑（CDT）或3-（2-吡啶基二硫代磷酸酯）的共轭化学，使荚膜多糖与载体蛋白共价共轭 ） - 丙酰肼（PDPH）。
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公开(公告)号：US20180256739A1
公开(公告)日：2018-09-13
申请号：US15972758
申请日：2018-05-07
申请人： Wyeth LLC
发明人： A. Krishna Prasad
IPC分类号： A61K47/64
CPC分类号： A61K47/646 , A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.
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公开(公告)号：US09623100B2
公开(公告)日：2017-04-18
申请号：US14811017
申请日：2015-07-28
申请人： Wyeth LLC
发明人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
IPC分类号： A61K39/085 , A61K47/48 , C08B37/00 , A61K39/00
CPC分类号： A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , C08B37/00
摘要： The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
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