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公开(公告)号：US20180250390A1
公开(公告)日：2018-09-06
申请号：US15972953
申请日：2018-05-07
申请人： Wyeth LLC
IPC分类号： A61K39/385 , A61K39/09 , A61K39/39 , A61K47/64 , A61K39/00
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
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公开(公告)号：US20140322263A1
公开(公告)日：2014-10-30
申请号：US14322167
申请日：2014-07-02
申请人： Wyeth LLC
发明人： George Rainer Siber , Peter R. Paradiso , Jill Hackell , Stephen Paul Lockhart , William P. Hausdorff
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K39/02 , A61K39/385 , A61K2039/6037
摘要： Methods of immunizing older adult subjects against Streptococcus pneumoniae infection are provided. Provided methods comprise immunization of naïve adult subjects with a conjugated pneumococcal polysaccharide vaccine. Optionally, initial immunization may be followed by additional immunization doses comprising conjugated pneumococcal polysaccharide vaccine or unconjugated pneumococcal polysaccharide vaccine composition.
摘要翻译： 提供了免疫老年成年人针对肺炎链球菌感染的方法。 提供的方法包括用共轭肺炎球菌多糖疫苗免疫初始成年受试者。 任选地，初始免疫可以之后是包含缀合的肺炎球菌多糖疫苗或非共轭肺炎球菌多糖疫苗组合物的另外的免疫剂量。
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公开(公告)号：US11191830B2
公开(公告)日：2021-12-07
申请号：US16528680
申请日：2019-08-01
申请人： Wyeth LLC
IPC分类号： A61K39/09 , A61K39/39 , A61K47/64 , A61K39/385 , A61K39/00
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
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公开(公告)号：US10780160B2
公开(公告)日：2020-09-22
申请号：US15972953
申请日：2018-05-07
申请人： Wyeth LLC
IPC分类号： A61K39/09 , A61K39/39 , A61K47/64 , A61K39/385 , A61K39/00
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
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公开(公告)号：US09981035B2
公开(公告)日：2018-05-29
申请号：US15042189
申请日：2016-02-12
申请人： Wyeth LLC
CPC分类号： A61K39/385 , A61K39/092 , A61K39/39 , A61K47/646 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
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6.发明授权公开(公告)号：US09480736B2
公开(公告)日：2016-11-01
申请号：US14520108
申请日：2014-10-21
申请人： Wyeth LLC
IPC分类号： A61K39/00 , A61K39/09 , A61K39/385
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6031 , A61K2039/6037
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.
摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。 还描述了一种用于制备包含与载体蛋白共价连接的肺炎链球菌血清型1多糖的免疫原性缀合物的方法，该方法包括在碱性pH缓冲液中通过轻度水解部分脱-O-乙酰化多糖。
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公开(公告)号：US20140314805A1
公开(公告)日：2014-10-23
申请号：US14322057
申请日：2014-07-02
申请人： Wyeth LLC
IPC分类号： A61K39/385 , A61K39/39 , A61K39/09
CPC分类号： A61K39/385 , A61K39/092 , A61K39/39 , A61K47/646 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。
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公开(公告)号：US20220023407A1
公开(公告)日：2022-01-27
申请号：US17494235
申请日：2021-10-05
申请人： Wyeth LLC
发明人： George Rainer Siber , Peter R. Paradiso , Jill Hackell , Stephen Paul Lockhart , William P. Hausdorff
IPC分类号： A61K39/09 , A61K39/385 , A61K39/02
摘要： Methods of immunizing older adult subjects against Streptococcus pneumoniae infection are provided. Provided methods comprise immunization of naïve adult subjects with a conjugated pneumococcal polysaccharide vaccine. Optionally, initial immunization may be followed by additional immunization doses comprising conjugated pneumococcal polysaccharide vaccine or unconjugated pneumococcal polysaccharide vaccine composition.
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公开(公告)号：US20190388537A1
公开(公告)日：2019-12-26
申请号：US16528680
申请日：2019-08-01
申请人： Wyeth LLC
IPC分类号： A61K39/385 , A61K47/64 , A61K39/09 , A61K39/39
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
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公开(公告)号：US09399060B2
公开(公告)日：2016-07-26
申请号：US14322057
申请日：2014-07-02
申请人： Wyeth LLC
IPC分类号： A61K39/385 , A61K39/09 , A61K39/116 , A61K39/39 , A61K47/48 , A61K39/00
CPC分类号： A61K39/385 , A61K39/092 , A61K39/39 , A61K47/646 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
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