公开(公告)号：US20230158101A1

公开(公告)日：2023-05-25

申请号：US18151155

申请日：2023-01-06

Applicant: Xellia Pharmaceuticals APS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

CPC classification number: A61K38/14 ,  A61K9/0019 ,  A61K47/183 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as an N-acetyl amino acid are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl amino acids.

公开(公告)号：US20220354927A1

公开(公告)日：2022-11-10

申请号：US17860642

申请日：2022-07-08

Applicant: Xellia Pharmaceuticals ApS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US11517609B2

公开(公告)日：2022-12-06

申请号：US17860642

申请日：2022-07-08

Applicant: Xellia Pharmaceuticals ApS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US11628200B2

公开(公告)日：2023-04-18

申请号：US17215675

申请日：2021-03-29

Applicant: Xellia Pharmaceuticals APS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US11000567B2

公开(公告)日：2021-05-11

申请号：US16677057

申请日：2019-11-07

Applicant: XELLIA PHARMACEUTICALS APS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US10188697B2

公开(公告)日：2019-01-29

申请号：US15524653

申请日：2015-11-06

Applicant: XELLIA PHARMACEUTICALS APS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US20210220433A1

公开(公告)日：2021-07-22

申请号：US17215675

申请日：2021-03-29

Applicant: Xellia Pharmaceuticals APS

Inventor： Ivona JASPRICA ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US10849956B2

公开(公告)日：2020-12-01

申请号：US16216446

申请日：2018-12-11

Applicant: XELLIA PHARMACEUTICALS APS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

公开(公告)号：US10039804B2

公开(公告)日：2018-08-07

申请号：US15827719

申请日：2017-11-30

Applicant: XELLIA PHARMACEUTICALS APS

Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

IPC: A61K38/14 ,  A61K9/08 ,  A61K47/18

Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.