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公开(公告)号：US20240139278A1
公开(公告)日：2024-05-02
申请号：US18392896
申请日：2023-12-21
发明人： Ivona Jasprica , Marcel Lagedroste
IPC分类号： A61K38/095 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： A61K38/095 , A61K47/12 , A61K47/183 , A61K47/26
摘要： The present disclosure relates to a ready-to-administer formulation of oxytocin, its pharmaceutically acceptable salts, or derivatives thereof, as well as products including the formulation. Specifically, the disclosure is directed to storage stable ready-to-administer formulations of oxytocin, method of producing such formulations and uses thereof.
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公开(公告)号：US20230158101A1
公开(公告)日：2023-05-25
申请号：US18151155
申请日：2023-01-06
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
CPC分类号： A61K38/14 , A61K9/0019 , A61K47/183 , A61K9/08
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as an N-acetyl amino acid are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl amino acids.
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公开(公告)号：US20220354927A1
公开(公告)日：2022-11-10
申请号：US17860642
申请日：2022-07-08
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US11628200B2
公开(公告)日：2023-04-18
申请号：US17215675
申请日：2021-03-29
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US11000567B2
公开(公告)日：2021-05-11
申请号：US16677057
申请日：2019-11-07
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US10188697B2
公开(公告)日：2019-01-29
申请号：US15524653
申请日：2015-11-06
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US10849956B2
公开(公告)日：2020-12-01
申请号：US16216446
申请日：2018-12-11
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US10039804B2
公开(公告)日：2018-08-07
申请号：US15827719
申请日：2017-11-30
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US11517609B2
公开(公告)日：2022-12-06
申请号：US17860642
申请日：2022-07-08
发明人： Ivona Jasprica , Sabina Keser , Katarina Pindric
摘要： Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US20220218784A1
公开(公告)日：2022-07-14
申请号：US17610108
申请日：2020-05-08
IPC分类号： A61K38/12 , A61K47/02 , A61K47/10 , A61K9/08 , A61K47/22 , A61K47/20 , A61K47/18 , A61K47/26
摘要： The present disclosure is related to providing a stable daptomycin aqueous pharmaceutical formulations as a contrast to the inconvenient and potentially problematic methods of lyophilized drug preparation and administration, wherein the aqueous formulations of daptomycin offer the advantage of ease of handling with a high degree of patient acceptability and compliance.
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