公开(公告)号：US20250059189A1

公开(公告)日：2025-02-20

申请号：US18746981

申请日：2024-06-18

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Verner Alexander LOFSTRAND ,  Jung Yun KIM ,  Helen CLEMENT ,  Kristen Nicole BURFORD ,  Paul CHARIFSON ,  Shawn JOHNSTONE ,  Juliette SABBATANI ,  Jan Felix SCHOLTES ,  Wei ZHANG ,  Shaoyi SUN

IPC: C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D491/052

Abstract: The present disclosure is directed to compounds of formula (I): wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

公开(公告)号：US20250129044A1

公开(公告)日：2025-04-24

申请号：US18669938

申请日：2024-05-21

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Verner Alexander LOFSTRAND ,  Jung Yun KIM ,  Helen CLEMENT ,  Kristen Nicole BURFORD ,  Paul CHARIFSON ,  Michael CLARK

IPC: C07D401/12 ,  C07D211/56 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/08 ,  C07D487/08 ,  C07D487/10 ,  C07D497/08 ,  C07D498/04 ,  C07D498/08

Abstract: The present disclosure is directed to compounds of formula (I): wherein X, Y, Z, R1, R2a, R2b, R3, and L are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.